{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:24:19Z","timestamp":1792621459474,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"suppl_4","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Considerable efforts have been made to better understand the effectiveness of large-scale preventive chemotherapy therapy for the control of morbidity caused by infection with soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura, and the 2 hookworm species, Necator americanus and Ancylostoma duodenale. Current World Health Organization (WHO) guidelines for STH control include mass drug administration (MDA) programs based on prevalence measurements, aiming at reducing morbidity in pre\u2013school-aged children (pre-SAC) and school-aged children (SAC) by lowering the prevalence of moderate- to heavy-intensity infections to &lt;1%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We project the likely impact of following the current WHO guidelines and assess whether the WHO morbidity goals will be achieved across a range of transmission settings. We also investigate modifications that could be made to the current WHO treatment guidelines, and project their potential impacts in achieving morbidity and transmission control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>While the standard guidelines are sufficient at low transmission levels, community-wide treatment (ie, involving pre-SAC, SAC, and adults) is essential if WHO morbidity goals are to be met in moderate- to high-transmission settings. Moreover, removing the recommendation of decreasing the treatment frequency at midline (5\u20136 years after the start of MDA) further improves the likelihood of achieving morbidity control in SAC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We meld analyses based on 2 mathematical models of parasite transmission and control by MDA for the dominant STH species, to generate a unified treatment approach applicable across all settings, regardless of which STH infection is most common. We recommend clearly defined changes to the current WHO guidelines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciy002","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T20:09:57Z","timestamp":1516997397000},"page":"S253-S259","source":"Crossref","is-referenced-by-count":77,"title":["Investigating the Effectiveness of Current and Modified World Health Organization Guidelines for the Control of Soil-Transmitted Helminth Infections"],"prefix":"10.1093","volume":"66","author":[{"given":"Sam H","family":"Farrell","sequence":"first","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, St Mary\u2019s Campus, Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc E","family":"Coffeng","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Truscott","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, St Mary\u2019s Campus, Imperial College London, United Kingdom"},{"name":"DeWorm3 Project, Natural History Museum of London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Werkman","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, St Mary\u2019s Campus, Imperial College London, United Kingdom"},{"name":"DeWorm3 Project, Natural History Museum of London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet","family":"Toor","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, St Mary\u2019s Campus, Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sake J","family":"de Vlas","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M","family":"Anderson","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, St Mary\u2019s Campus, Imperial College London, United Kingdom"},{"name":"DeWorm3 Project, Natural History Museum of London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"2019071815504704000_CIT0001","volume-title":"Helminth control in school-age children: a guide for managers of control programmes","author":"World Health Organization","year":"2011"},{"key":"2019071815504704000_CIT0002","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1756-3305-5-81","article-title":"The global limits and population at risk of soil-transmitted helminth infections in 2010","volume":"5","author":"Pullan","year":"2012","journal-title":"Parasit Vectors"},{"key":"2019071815504704000_CIT0003","volume-title":"Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions","author":"World Health Organization","year":"2006"},{"key":"2019071815504704000_CIT0004","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators","year":"2017","journal-title":"Lancet"},{"key":"2019071815504704000_CIT0005","doi-asserted-by":"crossref","first-page":"e0004566","DOI":"10.1371\/journal.pntd.0004566","article-title":"Complexities and perplexities: a critical appraisal of the evidence for soil-transmitted helminth infection-related morbidity","volume":"10","author":"Campbell","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2019071815504704000_CIT0006","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm","volume":"367","author":"Bethony","year":"2006","journal-title":"Lancet"},{"key":"2019071815504704000_CIT0007","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0035-9203(86)90384-6","article-title":"The epidemiology and control of intestinal helminths in the Pulicat Lake region of southern India. 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