{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:26:33Z","timestamp":1790234793032,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOE\/CHAN\/02\/02"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOE\/CHAN\/02\/02"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,2]]},"DOI":"10.1093\/cid\/ciy063","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T15:09:57Z","timestamp":1516979397000},"page":"261-268","source":"Crossref","is-referenced-by-count":46,"title":["Viral Load and Sequence Analysis Reveal the Symptom Severity, Diversity, and Transmission Clusters of Rhinovirus Infections"],"prefix":"10.1093","volume":"67","author":[{"given":"Kim Tien","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Yong","family":"Oong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin How","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Bee","family":"Chook","sequence":"additional","affiliation":[{"name":"Sunway Institute for Healthcare Development, Sunway University, Bandar Sunway, Selangor Darul Ehsan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takebe","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"},{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoke Fun","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Gan","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nik Sherina","family":"Hanafi","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Kek","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeeba","family":"Kamarulzaman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Keng","family":"Tee","sequence":"additional","affiliation":[{"name":"Sunway Institute for Healthcare Development, Sunway University, Bandar Sunway, Selangor Darul Ehsan"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"key\n\t\t\t\t20180702005812_CIT0001","first-page":"135","article-title":"Human rhinoviruses","volume":"26","author":"Jacobs","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180702005812_CIT0002","first-page":"1886","article-title":"Fatal respiratory infections associated with rhinovirus outbreak, Vietnam","volume":"18","author":"Hai","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180702005812_CIT0003","first-page":"70","article-title":"Clinical and molecular characterization of rhinoviruses A, B, and C in adult patients with pneumonia","volume":"63","author":"Choi","year":"2015","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20180702005812_CIT0004","first-page":"117","article-title":"Effect of respiratory virus infections including rhinovirus on clinical status in cystic fibrosis","volume":"73","author":"Smyth","year":"1995","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20180702005812_CIT0005","first-page":"267","article-title":"The role of rhinovirus in asthma exacerbations","volume":"116","author":"Friedlander","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20180702005812_CIT0006","first-page":"3655","article-title":"Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children","volume":"45","author":"Lau","year":"2007","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180702005812_CIT0007","first-page":"1187","article-title":"Impact of human rhinovirus types and viral load on the severity of illness in hospitalized children with lower respiratory tract infections","volume":"34","author":"Xiao","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180702005812_CIT0008","first-page":"532","article-title":"Comparison of viral load in individuals with and without asthma during infections with rhinovirus","volume":"189","author":"Kennedy","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180702005812_CIT0009","first-page":"102","article-title":"A one-step, real-time PCR assay for rapid detection of rhinovirus","volume":"12","author":"Do","year":"2010","journal-title":"J Mol Diagn"},{"key":"key\n\t\t\t\t20180702005812_CIT0010","first-page":"926","article-title":"The impact of clinical, demographic and risk factors on rates of HIV transmission: a population-based phylogenetic analysis in British Columbia, Canada","volume":"211","author":"Poon","year":"2015","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180702005812_CIT0011","first-page":"97","article-title":"Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa","volume":"524","author":"Carroll","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180702005812_CIT0012","first-page":"861","article-title":"Are meteorological parameters associated with acute respiratory tract infections","volume":"49","author":"du Prel","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180702005812_CIT0013","first-page":"e0136254","article-title":"Epidemiological and evolutionary dynamics of influenza B viruses in Malaysia, 2012\u20132014","volume":"10","author":"Oong","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180702005812_CIT0014","first-page":"267","article-title":"Transmission of the common cold to volunteers under controlled conditions. I. The common cold as a clinical entity","volume":"101","author":"Jackson","year":"1958","journal-title":"AMA Arch Intern Med"},{"key":"key\n\t\t\t\t20180702005812_CIT0015","first-page":"231","article-title":"A cross-sectional analysis of symptom severity in adults with influenza and other acute respiratory illness in the outpatient setting","volume":"14","author":"VanWormer","year":"2014","journal-title":"BMC Infect Dis"},{"key":"key\n\t\t\t\t20180702005812_CIT0016","first-page":"117","article-title":"Respiratory severity score separates upper versus lower respiratory tract infections and predicts measures of disease severity","volume":"28","author":"Feldman","year":"2015","journal-title":"Pediatr Allergy Immunol Pulmonol"},{"key":"key\n\t\t\t\t20180702005812_CIT0017","first-page":"333","article-title":"Genetic clustering of all 102 human rhinovirus prototype strains: serotype 87 is close to human enterovirus 70","volume":"83","author":"Savolainen","year":"2002","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t20180702005812_CIT0018","first-page":"34855","article-title":"Performance of a TaqMan assay for improved detection and quantification of human rhinovirus viral load","volume":"6","author":"Ng","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180702005812_CIT0019","first-page":"648","article-title":"Systematic review and meta-analysis of respiratory viral coinfections in children","volume":"21","author":"Lim","year":"2016","journal-title":"Respirology"},{"key":"key\n\t\t\t\t20180702005812_CIT0020","first-page":"e99392","article-title":"Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis","volume":"9","author":"Asner","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180702005812_CIT0021","first-page":"598","article-title":"Viral load is strongly associated with length of stay in adults hospitalised with viral acute respiratory illness","volume":"73","author":"Clark","year":"2016","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20180702005812_CIT0022","first-page":"1135","article-title":"Rhinovirus load and disease severity in children with lower respiratory tract infections","volume":"84","author":"Takeyama","year":"2012","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t20180702005812_CIT0023","first-page":"32","article-title":"Rapid detection and quantitation of poliovirus and rhinovirus sequences in viral stocks and infected cells","volume":"157","author":"Kotla","year":"2009","journal-title":"J Virol Methods"},{"key":"key\n\t\t\t\t20180702005812_CIT0024","first-page":"e10588","article-title":"Rhinovirus genome evolution during experimental human infection","volume":"5","author":"Cordey","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180702005812_CIT0025","first-page":"E322","article-title":"Virus shedding after human rhinovirus infection in children, adults and patients with hypogammaglobulinaemia","volume":"19","author":"Peltola","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180702005812_CIT0026","first-page":"311","article-title":"Clinical severity and molecular typing of human rhinovirus C strains during a fall outbreak affecting hospitalized patients","volume":"45","author":"Piralla","year":"2009","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20180702005812_CIT0027","article-title":"Rhinovirus C, asthma, and cell surface expression of virus receptor CDHR3","volume":"91","author":"Palmenberg","year":"2017","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20180702005812_CIT0028","first-page":"5485","article-title":"Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication","volume":"112","author":"Bochkov","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180702005812_CIT0029","first-page":"287","article-title":"Pathogenesis of rhinovirus infection","volume":"2","author":"Kennedy","year":"2012","journal-title":"Curr Opin Virol"},{"key":"key\n\t\t\t\t20180702005812_CIT0030","first-page":"15198","article-title":"Co-infections and transmission networks of HCV, HIV-1 and HPgV among people who inject drugs","volume":"5","author":"Ng","year":"2015","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180702005812_CIT0031","first-page":"27730","article-title":"Genetic diversity, seasonality and transmission network of human metapneumovirus: identification of a unique sub-lineage of the fusion and attachment genes","volume":"6","author":"Chow","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180702005812_CIT0032","first-page":"ofw001","article-title":"Molecular epidemiology of rhinovirus detections in young children","volume":"3","author":"Howard","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"key\n\t\t\t\t20180702005812_CIT0033","first-page":"1001","article-title":"Weekly monitoring of children with asthma for infections and illness during common cold seasons","volume":"125","author":"Olenec","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20180702005812_CIT0034","first-page":"633","article-title":"Diverse human rhinoviruses A and C from children with respiratory infections in Kuala Lumpur, Malaysia","volume":"64","author":"Chan","year":"2012","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20180702005812_CIT0035","first-page":"1110","article-title":"Humidity and respiratory virus transmission in tropical and temperate settings","volume":"143","author":"Paynter","year":"2015","journal-title":"Epidemiol Infect"},{"key":"key\n\t\t\t\t20180702005812_CIT0036","first-page":"e171231","article-title":"Evidence-based options for controlling respiratory virus transmission","volume":"23","author":"Cowling","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180702005812_CIT0037","first-page":"2194","article-title":"Respiratory virus transmission dynamics determine timing of asthma exacerbation peaks: evidence from a population-level model","volume":"113","author":"Eggo","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180702005812_CIT0038","first-page":"90","article-title":"Environmental factors affecting the transmission of respiratory viruses","volume":"2","author":"Pica","year":"2012","journal-title":"Curr Opin Virol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/67\/2\/261\/25103111\/ciy063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:58:39Z","timestamp":1530493119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/67\/2\/261\/4828127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,29]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,1,29]]},"published-print":{"date-parts":[[2018,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy063","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7,15]]},"published":{"date-parts":[[2018,1,29]]}}}