{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:15:16Z","timestamp":1793207716589,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS 80554"],"award-info":[{"award-number":["FIS 80554"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between community-acquired respiratory viruses (CARVs) and chronic lung allograft dysfunction (CLAD) in lung transplant recipients is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a prospective cohort study (2009\u20132014) in all consecutive adult patients (\u226518 years) undergoing lung transplantation in the Hospital Universitari Vall d\u2019Hebron (Barcelona, Spain). We systematically collected nasopharyngeal swabs from asymptomatic patients during seasonal changes, from patients with upper respiratory tract infectious disease, lower respiratory tract infectious disease (LRTID), or acute rejection. Nasopharyngeal swabs were analyzed by multiplex polymerase chain reaction. Primary outcome was to evaluate the potential association of CARVs and development of CLAD. Time-dependent Cox regression models were performed to identify the independent risk factors for CLAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 98 patients (67 bilateral lung transplant recipients; 63.3% male; mean age, 49.9 years) were included. Mean postoperative follow-up was 3.4 years (interquartile range [IQR], 2.5\u20134.0 years). Thirty-eight lung transplant recipients (38.8%) developed CLAD, in a median time of 20.4 months (IQR, 12\u201330.4 months). In time-controlled multivariate analysis, CARV-LRTID (hazard ratio [HR], 3.00 [95% confidence interval {CI}, 1.52\u20135.91]; P = .002), acute rejection (HR, 2.97 [95% CI, 1.51\u20135.83]; P = .002), and cytomegalovirus pneumonitis (HR, 3.76 [95% CI, 1.23\u201311.49]; P = .02) were independent risk factors associated with developing CLAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lung transplant recipients with CARVs in the lower respiratory tract are at increased risk to develop CLAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciy1047","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T23:16:16Z","timestamp":1544570176000},"page":"1192-1197","source":"Crossref","is-referenced-by-count":74,"title":["Community-acquired Respiratory Viruses Are a Risk Factor for Chronic Lung Allograft Dysfunction"],"prefix":"10.1093","volume":"69","author":[{"given":"Maddalena","family":"Peghin","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Group, Vall d\u2019Hebron Research Institute, Department of Infectious Diseases, Hospital Universitari Vall d\u2019Hebron, Barcelona"},{"name":"Spanish Network for Research in Infectious Diseases, Instituto de Salud Carlos III, Madrid"},{"name":"Infectious Diseases Clinic, Department of Medicine, University of Udine and Santa Maria Misericordia Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-2702","authenticated-orcid":false,"given":"Ibai","family":"Los-Arcos","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Group, Vall d\u2019Hebron Research Institute, Department of Infectious Diseases, Hospital Universitari Vall d\u2019Hebron, Barcelona"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans H","family":"Hirsch","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, Basel University Hospital, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Codina","sequence":"first","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases, Instituto de Salud Carlos III, Madrid"},{"name":"Department of Microbiology, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Monforte","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Lung Transplant Unit, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Bravo","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Lung Transplant Unit, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Berastegui","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Lung Transplant Unit, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Jauregui","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Romero","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Cabral","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Group, Vall d\u2019Hebron Research Institute, Department of Infectious Diseases, Hospital Universitari Vall d\u2019Hebron, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Ferrer","sequence":"first","affiliation":[{"name":"Intensive Care Department, Hospital Universitari Vall d\u2019Hebron, Barcelona"},{"name":"Shock, Organ Dysfunction and Resuscitation Research Group, Vall d\u2019 Hebron Research Institute, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Sacanell","sequence":"first","affiliation":[{"name":"Intensive Care Department, Hospital Universitari Vall d\u2019Hebron, Barcelona"},{"name":"Shock, Organ Dysfunction and Resuscitation Research Group, Vall d\u2019 Hebron Research Institute, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rom\u00e1n","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Lung Transplant Unit, Hospital Universitari Vall d\u2019Hebron, Barcelona"},{"name":"Ciber Enfermedades Respiratorias, Instituto de Salud 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