{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:27:35Z","timestamp":1782325655492,"version":"3.54.5"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Spontaneous splenic rupture is an increasingly reported complication of babesiosis and has been described as a severe complication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective chart review in a high-prevalence area to identify 7 cases of babesiosis-related splenic rupture between 2014 and 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Splenic rupture occurred in approximately 1% of babesiosis cases. Compared to cases without splenic rupture, these patients were younger (by &amp;gt;10 years), healthier (most with \u22641 comorbidity), had a lower degree of parasitemia (&amp;lt;10%), and were less likely to have end-organ dysfunction other than their splenic involvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Younger, healthier patients may be more prone to develop splenic rupture, as splenic histiocytes engage in more robust erythrophagocytosis, leading to pathological mechanical strain and rupture.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciy1060","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T20:15:20Z","timestamp":1544213720000},"page":"1212-1217","source":"Crossref","is-referenced-by-count":22,"title":["Babesiosis-associated Splenic Rupture: Case Series From a Hyperendemic Region"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9406-1351","authenticated-orcid":false,"given":"Kavin M","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University , Providence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie E","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University , Providence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Reece","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University , Providence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard A","family":"Mermel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University , Providence"},{"name":"Division of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University , Providence"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"2024111411405270400_CIT0001","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1056\/NEJMra1202018","article-title":"Human babesiosis","volume":"366","author":"Vannier","year":"2012","journal-title":"N Engl J Med"},{"key":"2024111411405270400_CIT0002","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/IPC.0b013e31809fe523","article-title":"Babesiosis, significance of spleen function illustrated by postsplenectomy course in 3 cases","volume":"16","author":"Siderits","year":"2008","journal-title":"Infect Dis Clin Pract"},{"key":"2024111411405270400_CIT0003","first-page":"390","article-title":"Case report: spontaneous splenic rupture during 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