{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:21:22Z","timestamp":1792009282032,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1KL2TR002545-01"],"award-info":[{"award-number":["1KL2TR002545-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infective endocarditis (IE) often requires surgical intervention. An increasingly common cause of IE is injection drug use (IDU-IE). There is conflicting evidence on whether postoperative mortality differs between people with IDU-IE and people with IE from etiologies other than injection drug use (non\u2013IDU-IE). In this manuscript, we compare short-term postoperative mortality in IDU-IE vs non\u2013IDU-IE through systematic review and meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The review was conducted according to the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Publication databases were queried for key terms included in articles up to September 2017. Randomized controlled trials, prospective cohorts, or retrospective cohorts that reported on 30-day mortality or in-hospital\/operative mortality following valve surgery and that compared outcomes between IDU-IE and non\u2013IDU-IE were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen studies with 1593 patients (n = 341 [21.4%] IDU-IE) were included in the meta-analysis. IDU-IE patients more frequently had tricuspid valve infection, Staphylococcus infection, and heart failure before surgery. Meta-analysis revealed no statistically significant difference in 30-day postsurgical mortality or in-hospital mortality between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite differing preoperative clinical characteristics, early postoperative mortality does not differ between IDU-IE and non\u2013IDU-IE patients who undergo valve surgery. Future research on long-term outcomes following valve replacement is needed to identify opportunities for improved healthcare delivery with IDU-IE.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciy1064","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T20:13:56Z","timestamp":1544559236000},"page":"1120-1129","source":"Crossref","is-referenced-by-count":44,"title":["Drug Use and Postoperative Mortality Following Valve Surgery for Infective Endocarditis: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"69","author":[{"given":"Ryan","family":"Hall","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shaughnessy","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffin","family":"Boll","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Warner","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen W","family":"Boucher","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine, Boston, Massachusetts"},{"name":"Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raveendhara R","family":"Bannuru","sequence":"additional","affiliation":[{"name":"Center for Treatment Comparison and Integrative Analysis, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysse G","family":"Wurcel","sequence":"additional","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts"},{"name":"Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,22]]},"reference":[{"key":"2019091313020739900_CIT0001","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archinternmed.2008.603","article-title":"Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International 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