{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T16:58:10Z","timestamp":1774371490881,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.1093\/cid\/ciy130","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T12:09:34Z","timestamp":1518610174000},"page":"600-605","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Rifampin and Doxycycline Treatments in Patients With Uncomplicated Scrub Typhus: An Open-Label, Randomized, Controlled Trial"],"prefix":"10.1093","volume":"67","author":[{"given":"Yun Sung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Chosun University, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chosun University, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Ra","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chosun University, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Sun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chosun University, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"key\n\t\t\t\t20180801022939_CIT0001","first-page":"73","article-title":"Scrub typhus; risks, diagnostic issues, and management challenges","volume":"55","author":"Prakash","year":"2016","journal-title":"Res Rep Trop Med"},{"key":"key\n\t\t\t\t20180801022939_CIT0002","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1148\/rg.271065074","article-title":"Scrub typhus: clinical, pathologic, and imaging findings","volume":"27","author":"Jeong","year":"2007","journal-title":"Radiographics"},{"key":"key\n\t\t\t\t20180801022939_CIT0003","first-page":"240","article-title":"Serious complications in scrub typhus","volume":"31","author":"Tsay","year":"1998","journal-title":"J Microbiol Immunol Infect"},{"key":"key\n\t\t\t\t20180801022939_CIT0004","doi-asserted-by":"crossref","first-page":"e0155810","DOI":"10.1371\/journal.pone.0155810","article-title":"The correlation of endoscopic findings and clinical features in Korean patients with scrub typhus: a cohort study","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180801022939_CIT0005","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3109\/00365549709035911","article-title":"Scrub typhus associated with multiorgan failure: a case report","volume":"29","author":"Chi","year":"1997","journal-title":"Scand J Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0006","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3346\/jkms.2004.19.5.668","article-title":"Clinical role of interstitial pneumonia in patients with scrub typhus: a possible marker of disease severity","volume":"19","author":"Song","year":"2004","journal-title":"J Korean Med Sci"},{"key":"key\n\t\t\t\t20180801022939_CIT0007","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/AAC.01460-06","article-title":"Controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus","volume":"51","author":"Kim","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180801022939_CIT0008","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(96)02501-9","article-title":"Scrub typhus infections poorly responsive to antibiotics in northern Thailand","volume":"348","author":"Watt","year":"1996","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180801022939_CIT0009","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1086\/517742","article-title":"Azithromycin therapy for scrub typhus during pregnancy","volume":"27","author":"Choi","year":"1998","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0010","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1469-0691.2009.02865.x","article-title":"A serosurvey of Orientia tsutsugamushi from patients with scrub typhus","volume":"16","author":"Kim","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180801022939_CIT0011","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4269\/ajtmh.2006.75.542","article-title":"Usefulness of nested PCR for the diagnosis of scrub typhus in clinical practice: a prospective study","volume":"75","author":"Kim","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20180801022939_CIT0012","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1086\/425008","article-title":"A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus","volume":"39","author":"Kim","year":"2004","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0013","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0197-2456(82)90024-1","article-title":"\u201cProving the null hypothesis\u201d in clinical trials","volume":"3","author":"Blackwelder","year":"1982","journal-title":"Control Clin Trials"},{"key":"key\n\t\t\t\t20180801022939_CIT0014","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/clinids\/3.3.479","article-title":"Chloramphenicol: a review of its use in clinical practice","volume":"3","author":"Feder","year":"1981","journal-title":"Rev Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0015","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/01.inf.0000047864.80791.20","article-title":"Roxithromycin treatment of scrub typhus (tsutsugamushi disease) in children","volume":"22","author":"Lee","year":"2003","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180801022939_CIT0016","first-page":"39","article-title":"A preliminary report on the clinical efficacy of telithromycin for the treatment of scrub typhus","volume":"38","author":"Lim","year":"2006","journal-title":"Infect Chemother"},{"key":"key\n\t\t\t\t20180801022939_CIT0017","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1086\/425008","article-title":"A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus","volume":"39","author":"Kim","year":"2004","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0018","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1128\/AAC.32.2.285","article-title":"Chloramphenicol, gentamicin, and ciprofloxacin against murine scrub typhus","volume":"32","author":"McClain","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180801022939_CIT0019","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2169\/internalmedicine.51.7816","article-title":"Meta-analysis of drug treatment for scrub typhus in Asia","volume":"51","author":"Fang","year":"2012","journal-title":"Intern Med"},{"key":"key\n\t\t\t\t20180801022939_CIT0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(00)02728-8","article-title":"Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial","volume":"356","author":"Watt","year":"2000","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180801022939_CIT0021","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/clinids\/24.3.436","article-title":"Central nervous system involvement in patients with scrub typhus","volume":"24","author":"Pai","year":"1997","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0022","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diagmicrobio.2010.10.005","article-title":"Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi","volume":"69","author":"Kim","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20180801022939_CIT0023","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1128\/AAC.33.7.1078","article-title":"Penetration of doxycycline into cerebrospinal fluid in patients treated for suspected Lyme neuroborreliosis","volume":"33","author":"Dotevall","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180801022939_CIT0024","first-page":"1329","article-title":"Shock and cerebral infarct after rifampin re-exposure in a patient infected with human immunodeficiency virus","volume":"27","author":"Mart\u00ednez","year":"1998","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/67\/4\/600\/25368314\/ciy130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T23:33:50Z","timestamp":1570750430000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/67\/4\/600\/4860367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,2,15]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy130","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8,15]]},"published":{"date-parts":[[2018,2,15]]}}}