{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:49:29Z","timestamp":1791460169478,"version":"4.3.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1081420"],"award-info":[{"award-number":["OPP1081420"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["101148\/Z\/13\/Z"],"award-info":[{"award-number":["101148\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,31]]},"abstract":"<jats:p>In Cambodian villages, 3-month mass drug administration with high coverage using dihydroartemisinin-piperaquine was safe and was followed by the absence of clinical Plasmodium falciparum cases for at least 1 year, despite the presence of multidrug-resistant parasites.<\/jats:p>","DOI":"10.1093\/cid\/ciy196","type":"journal-article","created":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T07:06:50Z","timestamp":1520147210000},"page":"817-826","source":"Crossref","is-referenced-by-count":54,"title":["A Controlled Trial of Mass Drug Administration to Interrupt Transmission of Multidrug-Resistant Falciparum Malaria in Cambodian Villages"],"prefix":"10.1093","volume":"67","author":[{"given":"Rupam","family":"Tripura","sequence":"first","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"},{"name":"Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Peto","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguon","family":"Chea","sequence":"additional","affiliation":[{"name":"National Center for Parasitology, Entomology and Malaria Control, Phnom Penh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davoeung","family":"Chan","sequence":"additional","affiliation":[{"name":"Provincial Health Department, Battambang, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mavuto","family":"Mukaka","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasathorn","family":"Sirithiranont","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Dhorda","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"},{"name":"World-Wide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cholrawee","family":"Promnarate","sequence":"additional","affiliation":[{"name":"World-Wide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Imwong","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"von Seidlein","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jureeporn","family":"Duanguppama","sequence":"additional","affiliation":[{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krittaya","family":"Patumrat","sequence":"additional","affiliation":[{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekol","family":"Huy","sequence":"additional","affiliation":[{"name":"National Center for Parasitology, Entomology and Malaria Control, Phnom Penh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P","family":"Grobusch","sequence":"additional","affiliation":[{"name":"Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P J","family":"Day","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"White","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen M","family":"Dondorp","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"2019121022373210800_CIT0001","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"Noedl","year":"2008","journal-title":"N Engl J Med"},{"key":"2019121022373210800_CIT0002","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N Engl J Med"},{"key":"2019121022373210800_CIT0003","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1473-3099(12)70181-0","article-title":"Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study","volume":"12","author":"Amaratunga","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"2019121022373210800_CIT0004","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1473-3099(15)00487-9","article-title":"Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study","volume":"16","author":"Amaratunga","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2019121022373210800_CIT0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1475-2875-8-31","article-title":"The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia","volume":"8","author":"Maude","year":"2009","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0006","doi-asserted-by":"crossref","first-page":"e37166","DOI":"10.1371\/journal.pone.0037166","article-title":"Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance","volume":"7","author":"Maude","year":"2012","journal-title":"PLoS One"},{"key":"2019121022373210800_CIT0007","volume-title":"Global plan for artemisinin resistance containment (GPARC)","author":"World Health Organization","year":"2011"},{"key":"2019121022373210800_CIT0008","article-title":"The persistence and oscillations of submicroscopic Plasmodium falciparum and vivax infections over time in Vietnam: an open cohort study","author":"Thuy-Nhien","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2019121022373210800_CIT0009","first-page":"CD008846","article-title":"Mass drug administration for malaria","author":"Poirot","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2019121022373210800_CIT0010","volume-title":"Strategy for malaria elimination in the Greater Mekong subregion 2015\u201330","author":"World Health Organization","year":"2015"},{"key":"2019121022373210800_CIT0011","volume-title":"Eliminating malaria in the Greater Mekong Subregion: united to end a deadly disease","author":"World Health Organization","year":"2016"},{"key":"2019121022373210800_CIT0012","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1473-3099(17)30048-8","article-title":"The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study","volume":"17","author":"Imwong","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2019121022373210800_CIT0013","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12936-017-1703-5","article-title":"Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia","volume":"16","author":"Tripura","year":"2017","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0014","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1126\/science.352.6284.398","article-title":"Malaria wars","volume":"352","author":"Roberts","year":"2016","journal-title":"Science"},{"key":"2019121022373210800_CIT0015","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.352.6284.407","article-title":"The village recruiter","volume":"352","author":"Roberts","year":"2016","journal-title":"Science"},{"key":"2019121022373210800_CIT0016","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1016\/S0140-6736(16)32519-3","article-title":"Village drama against malaria","volume":"388","author":"Lim","year":"2016","journal-title":"Lancet"},{"key":"2019121022373210800_CIT0017","article-title":"High throughput ultra-sensitive molecular techniques to quantity low density malaria parasitaemias","volume":"52:3303\u20139","author":"Imwong","year":"2014","journal-title":"J Clin Microbiol"},{"key":"2019121022373210800_CIT0018","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1475-2875-11-71","article-title":"An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso","volume":"11","author":"Valea","year":"2012","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0019","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/1475-2875-10-267","article-title":"Coma in fatal adult human malaria is not caused by cerebral oedema","volume":"10","author":"Medana","year":"2011","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0020","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/JCM.00276-11","article-title":"Development of a highly sensitive genus-specific quantitative reverse transcriptase real-time PCR assay for detection and quantitation of Plasmodium by amplifying RNA and DNA of the 18S rRNA genes","volume":"49","author":"Kamau","year":"2011","journal-title":"J Clin Microbiol"},{"key":"2019121022373210800_CIT0021","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4269\/ajtmh.2004.70.110","article-title":"Forest malaria in Vietnam: a challenge for control","volume":"70","author":"Erhart","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"2019121022373210800_CIT0022","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/1475-2875-9-373","article-title":"Malaria transmission and vector behaviour in a forested malaria focus in central Vietnam and the implications for vector control","volume":"9","author":"Van Bortel","year":"2010","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0023","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12936-015-0601-y","article-title":"Epidemiology of forest malaria in central Vietnam: the hidden parasite reservoir","volume":"14","author":"Thanh","year":"2015","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0024","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4269\/ajtmh.2008.79.652","article-title":"Forest malaria in central Vietnam","volume":"79","author":"Sanh","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"2019121022373210800_CIT0025","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1475-2875-4-58","article-title":"Epidemiology of forest malaria in central Vietnam: a large scale cross-sectional survey","volume":"4","author":"Erhart","year":"2005","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0026","first-page":"18","article-title":"Risk factors for malaria infection among ethnic minorities in Binh Phuoc, Vietnam","volume":"40","author":"Abe","year":"2009","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2019121022373210800_CIT0027","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1586\/14787210.2015.1031744","article-title":"Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance","volume":"13","author":"von Seidlein","year":"2015","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2019121022373210800_CIT0028","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1508606","article-title":"Four artemisinin-based treatments in African pregnant women with malaria","volume":"374","author":"PREGACT Study Group","year":"2016","journal-title":"N Engl J Med"},{"key":"2019121022373210800_CIT0029","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1056\/NEJMc1403007","article-title":"Dihydroartemisinin-piperaquine failure in Cambodia","volume":"371","author":"Saunders","year":"2014","journal-title":"N Engl J Med"},{"key":"2019121022373210800_CIT0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.12688\/wellcomeopenres.12240.1","article-title":"Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: a pilot trial in four villages of eastern Myanmar","volume":"2","author":"Landier","year":"2017","journal-title":"Wellcome Open Res"},{"key":"2019121022373210800_CIT0031","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12936-017-1854-4","article-title":"Mass anti-malarial administration in western Cambodia: a qualitative study of factors affecting coverage","volume":"16","author":"Pell","year":"2017","journal-title":"Malar J"},{"key":"2019121022373210800_CIT0032","doi-asserted-by":"crossref","first-page":"81","DOI":"10.12688\/wellcomeopenres.12240.1","article-title":"Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: a pilot trial in four villages of eastern Myanmar","volume":"2","author":"Landier","year":"2017","journal-title":"Wellcome Open Res"},{"key":"2019121022373210800_CIT0033","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/S0140-6736(00)03127-5","article-title":"Malaria eradication on islands","volume":"356","author":"Kaneko","year":"2000","journal-title":"Lancet"},{"key":"2019121022373210800_CIT0034","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4269\/ajtmh.14-0254","article-title":"Review of mass drug administration for malaria and its operational challenges","volume":"93","author":"Newby","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"2019121022373210800_CIT0035","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.1016\/S2214-109X(17)30220-6","article-title":"Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study","volume":"5","author":"Brady","year":"2017","journal-title":"Lancet Glob Health"},{"key":"2019121022373210800_CIT0036","volume-title":"Mass drug administration for falciparum malaria: a practical field manual","author":"World Health Organization","year":"2017"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/67\/6\/817\/25632915\/ciy196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/67\/6\/817\/25632915\/ciy196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T22:37:54Z","timestamp":1576017474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/67\/6\/817\/4924016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,7]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,3,7]]},"published-print":{"date-parts":[[2018,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy196","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9,15]]},"published":{"date-parts":[[2018,3,7]]}}}