{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:14:19Z","timestamp":1778634859036,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["RED0028\/2012"],"award-info":[{"award-number":["RED0028\/2012"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409985\/2016-3"],"award-info":[{"award-number":["409985\/2016-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,15]]},"DOI":"10.1093\/cid\/ciy289","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T07:10:29Z","timestamp":1523862629000},"page":"1427-1433","source":"Crossref","is-referenced-by-count":25,"title":["Early Juvenile Human T-cell Lymphotropic Virus Type-1\u2013Associated Myelopathy\/Tropical Spastic Paraparesis: Study of 25 Patients"],"prefix":"10.1093","volume":"67","author":[{"given":"Cinthya Maria Neves","family":"Varandas","sequence":"first","affiliation":[{"name":"Pediatric Neurology Unit, Hospital Santo Antonio das Obras Sociais Irm\u00e3 Dulce, Salvador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Lucas Sena","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology, Professor Edgard Santos Teaching Hospital, Federal University of Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janeusa Rita L","family":"Primo","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Hospital Santo Antonio das Obras Sociais Irm\u00e3 Dulce, Salvador"},{"name":"Department of Internal Medicine, Professor Edgard Santos Teaching Hospital, Federal University of Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima S P","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Professor Edgard Santos Teaching Hospital, Federal University of Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00e1vio","family":"Moreno-Carvalho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Professor Edgard Santos Teaching Hospital, Federal University of Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Farre","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology, Gon\u00e7alo Muniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil"},{"name":"Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L\u2019Hospitalet del Llobregat, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achil\u00e9a L","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Professor Edgard Santos Teaching Hospital, Federal University of Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"key\n\t\t\t\t20181015010300841_CIT0001","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological aspects and world distribution of HTLV-1 infection","volume":"3","author":"Gessain","year":"2012","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0002","first-page":"490","article-title":"HTLV-I in the general population of Salvador, Brazil: a city with African ethnic and sociodemographic characteristics","volume":"26","author":"Dourado","year":"2001","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20181015010300841_CIT0003","article-title":"Early onset of HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and adult T-cell leukemia\/lymphoma (ATL): systematic search and review","author":"Oliveira","year":"2017","journal-title":"J Trop Pediatr"},{"key":"key\n\t\t\t\t20181015010300841_CIT0004","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ana.410280110","article-title":"Nationwide survey of HTLV-I-associated myelopathy in Japan: association with blood transfusion","volume":"28","author":"Osame","year":"1990","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jns.2005.05.010","article-title":"HTLV-1 proviral load in peripheral blood mononuclear cells quantified in 100 HAM\/TSP patients: a marker of disease progression","volume":"237","author":"Olindo","year":"2005","journal-title":"J Neurol Sci"},{"key":"key\n\t\t\t\t20181015010300841_CIT0006","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0140-6736(98)09460-4","article-title":"Human T-lymphotropic virus type I infection","volume":"353","author":"Manns","year":"1999","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20181015010300841_CIT0007","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1086\/432066","article-title":"Outcomes of early life exposure to human T cell lymphotropic virus type 1","volume":"41","author":"Hanchard","year":"2005","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20181015010300841_CIT0008","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/cid\/cis273","article-title":"Infective dermatitis associated with human T-cell lymphotropic virus type 1: evaluation of 42 cases observed in Bahia, Brazil","volume":"54","author":"de Oliveira","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20181015010300841_CIT0009","author":"World Health Organization"},{"key":"key\n\t\t\t\t20181015010300841_CIT0010","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1212\/WNL.46.4.1016","article-title":"Interferon-alpha is effective in HTLV-I-associated myelopathy: a multicenter, randomized, double-blind, controlled trial","volume":"46","author":"Izumo","year":"1996","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20181015010300841_CIT0011","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20181015010300841_CIT0012","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1089\/aid.2006.22.931","article-title":"Proposal for diagnostic criteria of tropical spastic paraparesis\/HTLV-I-associated myelopathy (TSP\/HAM)","volume":"22","author":"De Castro-Costa","year":"2006","journal-title":"AIDS Res Hum Retroviruses"},{"key":"key\n\t\t\t\t20181015010300841_CIT0013","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jns.2004.04.006","article-title":"HTLV-I associated myelopathy\/tropical spastic paraparesis in a 7-year-old boy associated with infective dermatitis","volume":"222","author":"de Oliveira","year":"2004","journal-title":"J Neurol Sci"},{"key":"key\n\t\t\t\t20181015010300841_CIT0014","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1086\/432058","article-title":"Infective dermatitis and human T cell lymphotropic virus type 1-associated myelopathy\/tropical spastic paraparesis in childhood and adolescence","volume":"41","author":"Primo","year":"2005","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20181015010300841_CIT0015","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1086\/524695","article-title":"Early sequential development of infective dermatitis, human T cell lymphotropic virus type 1-associated myelopathy, and adult T cell leukemia\/lymphoma","volume":"46","author":"Farre","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20181015010300841_CIT0016","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1590\/S0004-282X2012000900007","article-title":"Difficulties in HAM\/TSP diagnosis","volume":"70","author":"Slater","year":"2012","journal-title":"Arq Neuropsiquiatr"},{"key":"key\n\t\t\t\t20181015010300841_CIT0017","first-page":"687","article-title":"Infantile onset of HTLV-I-associated myelopathy (HAM\/TSP)","volume":"85","author":"Bhigjee","year":"1995","journal-title":"S Afr Med J"},{"key":"key\n\t\t\t\t20181015010300841_CIT0018","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1089\/aid.2013.0086","article-title":"Incidence of human T cell lymphotropic virus type 1-associated myelopathy\/tropical spastic paraparesis in a long-term prospective cohort study of initially asymptomatic individuals in Brazil","volume":"29","author":"Romanelli","year":"2013","journal-title":"AIDS Res Hum Retroviruses"},{"key":"key\n\t\t\t\t20181015010300841_CIT0019","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1086\/423957","article-title":"Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis","volume":"39","author":"Gotuzzo","year":"2004","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20181015010300841_CIT0020","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1002\/ana.410230728","article-title":"The neuroepidemiology of tropical spastic paraparesis","volume":"23","author":"Rom\u00e1n","year":"1988","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0021","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1590\/S0004-282X1995000400009","article-title":"HTLV-I associated tropical spastic paraparesis: cerebral spinal fluid evolutive aspects in 128 cases","volume":"53","author":"Moreno-Carvalho","year":"1995","journal-title":"Arq Neuropsiquiatr"},{"key":"key\n\t\t\t\t20181015010300841_CIT0022","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2249.2008.03869.x","article-title":"Infective dermatitis has similar immunological features to human T lymphotropicvirus-type 1-associated myelopathy\/tropical spastic paraparesis","volume":"156","author":"Nascimento","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0023","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jcv.2013.07.012","article-title":"Clustering of HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil","volume":"58","author":"da Silva","year":"2013","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0024","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1002\/ana.410230733","article-title":"HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia\/lymphoma","volume":"23","author":"Usuku","year":"1988","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0025","first-page":"31","article-title":"HLA DRB1*DQB1* haplotype in HTLV-1-associated familial infective dermatitis may predict development of HTLV-1-associated myelopathy\/tropical spasticparaparesis","volume":"61","author":"La Grenade","year":"1996","journal-title":"Am J Med Genetics"},{"key":"key\n\t\t\t\t20181015010300841_CIT0026","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0022-510X(91)90119-R","article-title":"Analysis of factors of relevance to rapid clinical progression in HTLV-I-associated myelopathy","volume":"105","author":"Kuroda","year":"1991","journal-title":"J Neurol Sci"},{"key":"key\n\t\t\t\t20181015010300841_CIT0027","first-page":"63","article-title":"HTLV-I associated myelopathy (HAM): review and recent studies","volume":"11","author":"Osame","year":"1997","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20181015010300841_CIT0028","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/13550289509111010","article-title":"HTLV-I-associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings","volume":"1","author":"Nakagawa","year":"1995","journal-title":"J Neurovirol"},{"key":"key\n\t\t\t\t20181015010300841_CIT0029","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0022-510X(94)00266-Q","article-title":"Progression of neurological disability in HTLV-I-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"129","author":"Ara\u00fajo","year":"1995","journal-title":"J Neurol Sci"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/67\/9\/1427\/26038304\/ciy289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T18:14:44Z","timestamp":1571163284000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/67\/9\/1427\/4975518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,4,18]]},"published-print":{"date-parts":[[2018,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy289","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11,1]]},"published":{"date-parts":[[2018,4,18]]}}}