{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:26:07Z","timestamp":1792038367078,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1112355"],"award-info":[{"award-number":["OPP1112355"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["16IPA1609426"],"award-info":[{"award-number":["16IPA1609426"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["16IPA160"],"award-info":[{"award-number":["16IPA160"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have been associated with worse patient outcomes and higher costs of care than methicillin-susceptible (MSSA) infections. However, since prior studies found these differences, the healthcare landscape has changed, including widespread dissemination of community-associated strains of MRSA. We sought to provide updated estimates of the excess costs of MRSA infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective analysis using data from the National Inpatient Sample from the Agency for Healthcare Research and Quality for the years 2010\u20132014. We calculated costs for hospitalizations, including MRSA- and MSSA-related septicemia and pneumonia infections, as well as MRSA- and MSSA-related infections from conditions classified elsewhere and of an unspecified site (\u201cother infections\u201d). Differences in the costs of hospitalization were estimated using propensity score\u2013adjusted mortality outcomes for 2010\u20132014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 2014, estimated costs were highest for pneumonia and sepsis-related hospitalizations. Propensity score\u2013adjusted costs were significantly higher for MSSA-related pneumonia ($40725 vs $38561; P = .045) and other hospitalizations ($15578 vs $14792; P &amp;lt; .001) than for MRSA-related hospitalizations. Similar patterns were observed from 2010 to 2013, although crude cost differences between MSSA- and MRSA-related pneumonia hospitalizations rose from 25.8% in 2010 to 31.0% in 2014. Compared with MSSA-related hospitalizations, MRSA-related hospitalizations had a higher adjusted mortality rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although MRSA infections had been previously associated with higher hospitalization costs, our results suggest that, in recent years, costs associated with MSSA-related infections have converged with and may surpass costs of similar MRSA-related hospitalizations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciy399","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T19:14:18Z","timestamp":1525720458000},"page":"22-28","source":"Crossref","is-referenced-by-count":54,"title":["National Costs Associated With Methicillin-Susceptible and Methicillin-Resistant <i>Staphylococcus aureus<\/i> Hospitalizations in the United States, 2010\u20132014"],"prefix":"10.1093","volume":"68","author":[{"given":"Eili Y","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Center for Disease Dynamics, Economics & Policy, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Disease Dynamics, Economics & Policy, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Mojica","sequence":"additional","affiliation":[{"name":"Center for Disease Dynamics, Economics & Policy, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie K","family":"Tseng","sequence":"additional","affiliation":[{"name":"Center for Disease Dynamics, Economics & Policy, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"McNeill","sequence":"additional","affiliation":[{"name":"Reuters News Agency, New York"},{"name":"City University of New York Graduate School of Journalism, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Armstrong Institute for Patient Safety and Quality, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trish M","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, 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