{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:07:07Z","timestamp":1740128827254,"version":"3.37.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"AIDS Clinical Trial Group","award":["AI068636"],"award-info":[{"award-number":["AI068636"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32-GM-066691"],"award-info":[{"award-number":["T32-GM-066691"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor\u2013based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.<\/jats:p>","DOI":"10.1093\/cid\/ciy405","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T19:14:18Z","timestamp":1525720458000},"page":"1617-1620","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine"],"prefix":"10.1093","volume":"67","author":[{"given":"Matthew M","family":"Ippolito","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Center for Translational AIDS Research, Departments of Medicine and Neuroscience, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M","family":"Lederman","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Winterberg","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa A","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Flexner","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"volume-title":"Guidelines for the treatment of malaria","year":"2015","author":"World Health Organization","key":"2024111411404281800_CIT0001"},{"key":"2024111411404281800_CIT0002","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa062032","article-title":"Return of chloroquine antimalarial efficacy in Malawi","volume":"355","author":"Laufer","year":"2006","journal-title":"N Engl J Med"},{"key":"2024111411404281800_CIT0003","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4269\/ajtmh.16-0141","article-title":"Global epidemiology of Plasmodium vivax","volume":"95","author":"Howes","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"2024111411404281800_CIT0004","doi-asserted-by":"crossref","first-page":"e0173509","DOI":"10.1371\/journal.pone.0173509","article-title":"Development of an evidence evaluation and synthesis system for drug-drug interactions, and its application to a systematic review of HIV and malaria co-infection","volume":"12","author":"Seden","year":"2017","journal-title":"PLoS One"},{"key":"2024111411404281800_CIT0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2165\/00003088-199631040-00003","article-title":"Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements","volume":"31","author":"Ducharme","year":"1996","journal-title":"Clin Pharmacokinet"},{"key":"2024111411404281800_CIT0006","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/BF02976712","article-title":"Cytochrome P450 2C8 and CYP3A4\/5 are involved in chloroquine metabolism in human liver microsomes","volume":"26","author":"Kim","year":"2003","journal-title":"Arch Pharm Res"},{"key":"2024111411404281800_CIT0007","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00542151","article-title":"The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects","volume":"26","author":"Frisk-Holmberg","year":"1984","journal-title":"Eur J Clin Pharmacol"},{"key":"2024111411404281800_CIT0008","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00228-008-0492-8","article-title":"CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels","volume":"64","author":"Josephson","year":"2008","journal-title":"Eur J Clin Pharmacol"},{"key":"2024111411404281800_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mcp.2002.124519","article-title":"Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans","volume":"72","author":"Mouly","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"2024111411404281800_CIT0010","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2165\/00003495-199856060-00014","article-title":"Efavirenz","volume":"56","author":"Adkins","year":"1998","journal-title":"Drugs"},{"key":"2024111411404281800_CIT0011","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/00034983.1984.11811868","article-title":"In vitro assessment of the antimalarial activity of chloroquine and its major metabolites","volume":"78","author":"Aderounmu","year":"1984","journal-title":"Ann Trop Med Parasitol"},{"key":"2024111411404281800_CIT0012","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1089\/aid.2015.0336","article-title":"The effect of chloroquine on immune activation and interferon signatures associated with HIV-1","volume":"32","author":"Jacobson","year":"2016","journal-title":"AIDS Res Hum Retroviruses"},{"volume-title":"Guidance for industry: bioanalytical method validation (draft guidance)","year":"2013","author":"Food and Drug Administration","key":"2024111411404281800_CIT0013"},{"key":"2024111411404281800_CIT0014","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1124\/dmd.31.6.748","article-title":"In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation","volume":"31","author":"Projean","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"2024111411404281800_CIT0015","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2133\/dmpk.DMPK-12-RG-124","article-title":"In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19","volume":"28","author":"Xu","year":"2013","journal-title":"Drug Metab Pharmacokinet"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/67\/10\/1617\/26189590\/ciy405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/67\/10\/1617\/26189590\/ciy405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:12:54Z","timestamp":1731586374000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/67\/10\/1617\/4996547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,5,16]]},"published-print":{"date-parts":[[2018,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy405","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"type":"print","value":"1058-4838"},{"type":"electronic","value":"1537-6591"}],"subject":[],"published-other":{"date-parts":[[2018,11,15]]},"published":{"date-parts":[[2018,5,16]]}}}