{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:56:17Z","timestamp":1791989777860,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:00:00Z","timestamp":1529107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"RED de SIDA","award":["RD16\/0025\/0041"],"award-info":[{"award-number":["RD16\/0025\/0041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,18]]},"DOI":"10.1093\/cid\/ciy502","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T11:10:00Z","timestamp":1528888200000},"page":"482-489","source":"Crossref","is-referenced-by-count":17,"title":["Etiological Characterization of the Cutaneous Ulcer Syndrome in Papua New Guinea Using Shotgun Metagenomics"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-1395","authenticated-orcid":false,"given":"Marc","family":"Noguera-Julian","sequence":"first","affiliation":[{"name":"IrsiCaixa AIDS Research Institute, Badalona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Spain"},{"name":"Universitat de Vic-Universitat Central de Catalunya, Vic, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Gonz\u00e1lez-Beiras","sequence":"additional","affiliation":[{"name":"Lisbon Institute of Hygiene and Tropical Medicine, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Parera","sequence":"additional","affiliation":[{"name":"IrsiCaixa AIDS Research Institute, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ubals","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health, Hospital Cl\u00ednic-University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Kapa","sequence":"additional","affiliation":[{"name":"Lihir Medical Center\u2013International SOS, Newcrest Mining, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Paredes","sequence":"additional","affiliation":[{"name":"IrsiCaixa AIDS Research Institute, Badalona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Spain"},{"name":"Universitat de Vic-Universitat Central de Catalunya, Vic, Spain"},{"name":"HIV Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Mitj\u00e0","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health, Hospital Cl\u00ednic-University of Barcelona, Spain"},{"name":"Lihir Medical Center\u2013International SOS, Newcrest Mining, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,16]]},"reference":[{"key":"key\n\t\t\t\t2019011723582107400_CIT0001","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1016\/S2214-109X(14)70019-1","article-title":"Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study","volume":"2","author":"Mitj\u00e0","year":"2014","journal-title":"Lancet Glob Health"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0002","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3201\/eid2010.140573","article-title":"Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands","volume":"20","author":"Marks","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0003","doi-asserted-by":"crossref","first-page":"e0003496","DOI":"10.1371\/journal.pntd.0003496","article-title":"A cross-sectional study of \u2018yaws\u2019 in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control","volume":"9","author":"Ghinai","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0004","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0140-6736(12)62130-8","article-title":"Yaws","volume":"381","author":"Mitj\u00e0","year":"2013","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0005","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/sti.79.1.68","article-title":"Chancroid: clinical manifestations, diagnosis, and management","volume":"79","author":"Lewis","year":"2003","journal-title":"Sex Transm Infect"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0006","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(11)61624-3","article-title":"Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial","volume":"379","author":"Mitj\u00e0","year":"2012","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0007","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJMoa040216","article-title":"Macrolide resistance in Treponema pallidum in the United States and Ireland","volume":"351","author":"Lukehart","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0008","doi-asserted-by":"crossref","first-page":"e2222","DOI":"10.1371\/journal.pntd.0002222","article-title":"Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains","volume":"7","author":"Centurion-Lara","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0009","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1128\/JCM.35.6.1348-1352.1997","article-title":"Detection of Treponema pallidum by a sensitive reverse transcriptase PCR","volume":"35","author":"Centurion-Lara","year":"1997","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0010","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1086\/656533","article-title":"Enhanced molecular typing of Treponema pallidum: geographical distribution of strain types and association with neurosyphilis","volume":"202","author":"Marra","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0011","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1128\/JCM.34.1.49-54.1996","article-title":"Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ulcers","volume":"34","author":"Orle","year":"1996","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0012","author":"Andrews"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0013","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0014","volume-title":"BBMap short read aligner","author":"Bushnell","year":"2016"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0016","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0017","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2013"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0018","article-title":"Package \u201cvegan.\u201d","author":"Oksanen"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0019","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0140-6736(18)30204-6","article-title":"Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study","volume":"391","author":"Mitj\u00e0","year":"2018","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0020","first-page":"64","article-title":"Cases of cutaneous diphtheria in New Zealand: implications for surveillance and management","volume":"125","author":"Sears","year":"2012","journal-title":"N Z Med J"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0021","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2143\/ACB.3429","article-title":"A forgotten disease in a returning traveler from Thailand","volume":"68","author":"Depypere","year":"2013","journal-title":"Acta Clin Belg"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0022","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1128\/JCM.05038-11","article-title":"Characterization of Corynebacterium diphtheriae isolates from infected skin lesions in the Northern Territory of Australia","volume":"49","author":"Gordon","year":"2011","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0023","doi-asserted-by":"crossref","first-page":"1003.e1","DOI":"10.1016\/j.cmi.2016.08.010","article-title":"Outbreak investigation for toxigenic Corynebacterium diphtheriae wound infections in refugees from Northeast Africa and Syria in Switzerland and Germany by whole genome sequencing","volume":"22","author":"Meinel","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0024","doi-asserted-by":"crossref","first-page":"71","DOI":"10.7326\/0003-4819-111-1-71","article-title":"Diphtheria among alcoholic urban adults. A decade of experience in Seattle","volume":"111","author":"Harnisch","year":"1989","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2165\/00128071-200809040-00002","article-title":"Imported tropical infectious ulcers in travelers","volume":"9","author":"Zeegelaar","year":"2008","journal-title":"Am J Clin Dermatol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0026","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/clinids\/18.5.835-a","article-title":"Two cases of soft-tissue infection caused by Arcanobacterium haemolyticum","volume":"18","author":"Esteban","year":"1994","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0027","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/sur.2011.129","article-title":"Arcanobacterium haemolyticum osteomyelitis and sepsis: a diagnostic conundrum","volume":"14","author":"Brown","year":"2013","journal-title":"Surg Infect"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0028","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1099\/jmm.0.000038","article-title":"Bacteriological characteristics of Arcanobacterium haemolyticum isolated from seven patients with skin and soft-tissue infections","volume":"64","author":"Miyamoto","year":"2015","journal-title":"J Med Microbiol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0029","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/jtm.12074","article-title":"Corynebacterium diphtheriae and the returned tropical traveler","volume":"21","author":"May","year":"2014","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0030","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1056\/NEJMicm1701825","article-title":"Cutaneous diphtheria","volume":"378","author":"Wilson","year":"2018","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0031"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0032","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s10096-014-2092-0","article-title":"Streptococcus dysgalactiae subsp. equisimilis bacteremia: an emerging infection","volume":"33","author":"Rantala","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0033","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1099\/jmm.0.000052","article-title":"Group C Streptococcus dysgalactiae subsp. equisimilis in south-east Brazil: genetic diversity, resistance profile and the first report of human and equine isolates belonging to the same multilocus sequence typing lineage","volume":"64","author":"Silva","year":"2015","journal-title":"J Med Microbiol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0034","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cmi.2014.08.019","article-title":"Beta-haemolytic group A, C and G streptococcal infections in Western Norway: a 15-year retrospective survey","volume":"21","author":"Oppegaard","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0035","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s00284-017-1232-z","article-title":"Potential factors enabling human body colonization by animal Streptococcus dysgalactiae subsp. equisimilis strains","volume":"74","author":"Ciszewski","year":"2017","journal-title":"Curr Microbiol"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0036","volume-title":"Standard Treatment for Common Illnesses of Children in Papua New Guine, 10th Edition","author":"Paediatric Society of Papua New Guinea","year":"2016"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0037","first-page":"189","article-title":"Eradication of yaws\u2014the Morges strategy","volume":"87","author":"World Health Organization","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"key":"key\n\t\t\t\t2019011723582107400_CIT0038","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1056\/NEJMoa1408586","article-title":"Mass treatment with single-dose azithromycin for yaws","volume":"372","author":"Mitj\u00e0","year":"2015","journal-title":"N Engl J Med"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/68\/3\/482\/27512567\/ciy502.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T13:29:41Z","timestamp":1604410181000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/68\/3\/482\/5039156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,16]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,6,16]]},"published-print":{"date-parts":[[2019,1,18]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy502","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2,1]]},"published":{"date-parts":[[2018,6,16]]}}}