{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:50:08Z","timestamp":1788511808724,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Microbicide Trials Network"},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI068633"],"award-info":[{"award-number":["UM1AI068633"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI068615"],"award-info":[{"award-number":["UM1AI068615"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI106707"],"award-info":[{"award-number":["UM1AI106707"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,19]]},"DOI":"10.1093\/cid\/ciy654","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:03:24Z","timestamp":1533254604000},"page":"1144-1151","source":"Crossref","is-referenced-by-count":23,"title":["Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4437-4632","authenticated-orcid":false,"given":"Beatrice A","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh"},{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Statistical Center for HIV\/AIDS Research and Prevention\/Fred Hutchinson Cancer Research Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly M","family":"Gundacker","sequence":"additional","affiliation":[{"name":"Statistical Center for HIV\/AIDS Research and Prevention\/Fred Hutchinson Cancer Research Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W","family":"Hendrix","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J","family":"Hoesley","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Salata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene S","family":"Dezzutti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh"},{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"van der Straten","sequence":"additional","affiliation":[{"name":"Women\u2019s Global Health Imperative (WGHI) RTI International, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne B","family":"Hall","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy E","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Johnson","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"McGowan","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"},{"name":"Department of Medicine, University of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalene M","family":"Nel","sequence":"additional","affiliation":[{"name":"International Partnership for Microbicides, Silver Spring"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Soto-Torres","sequence":"additional","affiliation":[{"name":"Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Marzinke","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"MTN-024\/IPM 031 Protocol Team for the Microbicide Trials Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Hoesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Salata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"key\n\t\t\t\t2019031909381627900_CIT0001","author":"UNAIDS"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0002","author":"Centers for Disease Control and Prevention"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0003","volume-title":"Diagnoses of HIV infection among adults aged 50 years and older in the United States and dependent areas, 2010\u20132014","author":"Centers for Disease Control and Prevention"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0004","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2471\/BLT.13.119230","article-title":"Sexual health in older women","volume":"91","author":"Lusti-Narasimhan","year":"2013","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1300\/J074v17n03_04","article-title":"\u201cAre they still having sex?\u201d STIs and unintended pregnancy among mid-life women","volume":"17","author":"Sherman","year":"2005","journal-title":"J Women Aging"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0006","doi-asserted-by":"crossref","first-page":"204 e1","DOI":"10.1016\/j.ajog.2015.03.045","article-title":"The effect of menopause on the innate antiviral activity of cervicovaginal lavage","volume":"213","author":"Chappell","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0007","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/QAI.0b013e31823fd215","article-title":"CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women","volume":"59","author":"Meditz","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0008","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1089\/aid.2016.0320","article-title":"Comparison of mucosal markers of human immunodeficiency virus susceptibility in healthy premenopausal versus postmenopausal women","volume":"33","author":"Thurman","year":"2017","journal-title":"AIDS Res Hum Retroviruses"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0009","doi-asserted-by":"crossref","first-page":"324.e1","DOI":"10.1016\/j.ajog.2016.03.041","article-title":"Reduced levels of genital tract immune biomarkers in postmenopausal women: implications for HIV acquisition","volume":"215","author":"Jais","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/aji.12027","article-title":"Immunobiology of genital tract trauma: endocrine regulation of HIV acquisition in women following sexual assault or genital tract mutilation","volume":"69","author":"Ghosh","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0011","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.1193748","article-title":"Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.[Erratum appears in Science. 2011 Jul 29;333(6042):524]","volume":"329","author":"Abdool Karim","year":"2010","journal-title":"Science"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0012","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1202614","article-title":"Preexposure prophylaxis for HIV infection among African women","volume":"367","author":"Van Damme","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0013","doi-asserted-by":"crossref","first-page":"F13","DOI":"10.1097\/QAD.0b013e3283522272","article-title":"Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention","volume":"26","author":"van der Straten","year":"2012","journal-title":"AIDS"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0014","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a vaginal ring containing dapivirine for HIV-1 prevention in women","volume":"375","author":"Baeten","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0015","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMoa1602046","article-title":"Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women","volume":"375","author":"Nel","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0016","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0968-8080(12)40659-0","article-title":"New female condoms in the pipeline","volume":"20","author":"Beksinska","year":"2012","journal-title":"Reprod Health Matters"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0017","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1080\/10810730.2012.665423","article-title":"Media portrayals of the female condom","volume":"17","author":"Chatterjee","year":"2012","journal-title":"J Health Commun"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0018"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0019","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1097\/QAD.0000000000000280","article-title":"A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women","volume":"28","author":"Nel","year":"2014","journal-title":"AIDS"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0020","first-page":"1","article-title":"Pharmacokinetics and safety assessment of anti-HIV dapivirine vaginal microbicide rings with multiple dosing","volume":"5","author":"Nel","year":"2014","journal-title":"J AIDS Clin Res"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0021","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jpba.2014.06.018","article-title":"Dual quantification of dapivirine and maraviroc in cervicovaginal secretions from ophthalmic tear strips and polyester-based swabs via liquid chromatographic-tandem mass spectrometric (LC-MS\/MS) analysis","volume":"98","author":"Parsons","year":"2014","journal-title":"J Pharm Biomed Anal"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0022","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.4155\/bio.13.256","article-title":"The development and validation of an UHPLC-MS\/MS method for the rapid quantification of the antiretroviral agent dapivirine in human plasma","volume":"5","author":"Seserko","year":"2013","journal-title":"Bioanalysis"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0023","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jrs.4433","article-title":"A process analytical approach for quality control of dapivirine in HIV preventive vaginal rings by Raman spectroscopy","volume":"45","author":"Lyndgaard","year":"2014","journal-title":"J Raman Spectrosc"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0024","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1093\/jac\/dks173","article-title":"Reformulated tenofovir gel for use as a dual compartment microbicide","volume":"67","author":"Dezzutti","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0025","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1007\/s11095-015-1738-7","article-title":"Pharmacodynamic activity of dapivirine and maraviroc single entity and combination topical gels for HIV-1 prevention","volume":"32","author":"Dezzutti","year":"2015","journal-title":"Pharm Res"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0026","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/cid\/civ913","article-title":"Impact of sex on the pharmacokinetics and pharmacodynamics of 1% tenofovir gel","volume":"62","author":"Herold","year":"2016","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0027","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/QAI.0000000000000702","article-title":"Phase 1 safety, pharmacokinetics, and pharmacodynamics of dapivirine and maraviroc vaginal rings: a double-blind randomized trial","volume":"70","author":"Chen","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0028","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/jcph.248","article-title":"Expression of six drug transporters in vaginal, cervical, and colorectal tissues: implications for drug disposition in HIV prevention","volume":"54","author":"Nicol","year":"2014","journal-title":"J Clin Pharmacol"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0029","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bcp.2016.07.009","article-title":"Expression, regulation, and function of drug transporters in cervicovaginal tissues of a mouse model used for microbicide testing","volume":"116","author":"Zhou","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0030","doi-asserted-by":"crossref","first-page":"e0131405","DOI":"10.1371\/journal.pone.0131405","article-title":"Expression of genes for drug transporters in the human female genital tract and modulatory effect of antiretroviral drugs","volume":"10","author":"Hijazi","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019031909381627900_CIT0031","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.addr.2015.12.015","article-title":"Will dapivirine redeem the promises of anti-HIV microbicides? Overview of product design and clinical testing","volume":"103","author":"das Neves","year":"2016","journal-title":"Adv Drug Deliv Rev"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/68\/7\/1144\/28114776\/ciy654.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T23:09:50Z","timestamp":1553036990000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/68\/7\/1144\/5115671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,4]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,10,4]]},"published-print":{"date-parts":[[2019,3,19]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy654","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4,1]]},"published":{"date-parts":[[2018,10,4]]}}}