{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:24:40Z","timestamp":1782879880916,"version":"3.54.5"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008513","name":"Thomas Jefferson University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI107508-02"],"award-info":[{"award-number":["R21 AI107508-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)\u2013lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with \u03b2\u2013human papillomavirus (HPV)\u2013positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including \u03b2-HPV and EBV.<\/jats:p>","DOI":"10.1093\/cid\/ciy942","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T04:24:10Z","timestamp":1550463850000},"page":"1938-1941","source":"Crossref","is-referenced-by-count":39,"title":["Inherited Interleukin 2\u2013Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma"],"prefix":"10.1093","volume":"68","author":[{"given":"Leila","family":"Youssefian","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania"},{"name":"Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Iran"},{"name":"Genetics, Genomics and Cancer Biology PhD Program, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Vahidnezhad","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania"},{"name":"Biotechnology Research Center, Department of Molecular Medicine, Pasteur Institute of Iran, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Yousefi","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Iran"},{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences, Tehran University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Saeidian","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania"},{"name":"Genetics, Genomics and Cancer Biology PhD Program, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghavan","family":"Azizpour","sequence":"first","affiliation":[{"name":"Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Touati","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania"},{"name":"Drexel University College of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Nikbakht","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz Kamyab-","family":"Hesari","sequence":"first","affiliation":[{"name":"Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Adib-Sereshki","sequence":"first","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirous","family":"Zeinali","sequence":"first","affiliation":[{"name":"Biotechnology Research Center, Department 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fortina","sequence":"first","affiliation":[{"name":"Cancer Genomics and Bioinformatics, Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jouanguy","sequence":"first","affiliation":[{"name":"St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, France"},{"name":"Imagine Institute, Paris Descartes University, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"first","affiliation":[{"name":"St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller 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