{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:25:46Z","timestamp":1780410346838,"version":"3.54.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T00:00:00Z","timestamp":1542412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The World Health Organization (WHO) recommends an additional dose of measles-containing vaccine (MCV) for human immunodeficiency virus (HIV)\u2013infected children receiving highly active antiretroviral therapy following immune reconstitution. We conducted a systematic review to synthesize available evidence regarding measles seroprevalence and measles vaccine immunogenicity, efficacy, and safety in HIV-infected adolescents and adults to provide the evidence base for recommendations on the need for measles vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted searches of 8 databases through 26 September 2017. Identified studies were screened independently by 2 reviewers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 30 studies meeting inclusion criteria. Across studies, measles seroprevalence among HIV-infected adolescents and adults was high (median, 92%; 27 studies), with no significant difference compared to HIV-uninfected participants (10 studies). In 6 studies that evaluated the immunogenicity of MCVs among seronegative HIV-infected adults, measles seropositivity at end of follow-up ranged from 0% to 56% (median, 39%). No severe adverse events were reported following measles vaccination in HIV-infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on similar measles seroprevalence between HIV-infected and HIV-uninfected adolescents and adults, and the low response to vaccination, these studies do not support the need for an additional dose of MCV in HIV-infected adolescents and adults. These findings support WHO guidelines that measles vaccine be administered to potentially susceptible, asymptomatic HIV-infected adults, and may be considered for those with symptomatic HIV infection if not severely immunosuppressed. Measles-susceptible adolescents and adults, regardless of HIV status, may require targeted vaccination efforts to reach critical vaccination thresholds and achieve regional elimination goals.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciy980","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T20:16:54Z","timestamp":1542140214000},"page":"836-844","source":"Crossref","is-referenced-by-count":13,"title":["Measles Seroprevalence and Vaccine Responses in Human Immunodeficiency Virus\u2013infected Adolescents and Adults: A Systematic Review"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-3087","authenticated-orcid":false,"given":"Gideon","family":"Loevinsohn","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Rosman","sequence":"additional","affiliation":[{"name":"Welch Medical Library, School of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,17]]},"reference":[{"key":"2019081601550689300_CIT0001","unstructured":"World Health Organization. Measles, first dose (MCV1) immunization coverage by WHO region. Available at: http:\/\/apps.who.int\/gho\/data\/view.main.81100. Accessed 4 September 2018."},{"key":"2019081601550689300_CIT0002","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.15585\/mmwr.mm6642a6","article-title":"Progress toward regional measles elimination\u2014worldwide, 2000\u20132016","author":"Dabbagh","year":"2017","journal-title":"Morb Mortal Weekly Rep"},{"key":"2019081601550689300_CIT0003","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1001\/jama.1989.03420170056030","article-title":"Measles and measles immunity in children infected with human immunodeficiency virus","volume":"261","author":"Krasinski","year":"1989","journal-title":"JAMA"},{"key":"2019081601550689300_CIT0004","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3201\/eid1902.120301","article-title":"Lessons and challenges for measles control from unexpected large outbreak, Malawi","volume":"19","author":"Minetti","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"2019081601550689300_CIT0005","first-page":"205","article-title":"Measles vaccines: WHO position paper\u2014April 2017","volume":"92","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"key":"2019081601550689300_CIT0006","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2217\/fvl.10.75","article-title":"Immunologic basis for revaccination of HIV-infected children receiving HAART","volume":"6","author":"Rainwater-Lovett","year":"2011","journal-title":"Future Virol"},{"key":"2019081601550689300_CIT0007","unstructured":"Kroger AT , DuchinJ, V\u00e1zquezM General best practice guidelines for immunization. Best practices guidance of the Advisory Committee on Immunization Practices (ACIP). Available at: http:\/\/www.cdc.gov\/vaccines\/hcp\/acip-recs\/general-recs\/downloads\/general-recs.pdf. 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