{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:24:02Z","timestamp":1771993442709,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T00:00:00Z","timestamp":1547856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI090023 6556"],"award-info":[{"award-number":["U19AI090023 6556"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI057266 7533"],"award-info":[{"award-number":["U19AI057266 7533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Eugenio Litta"},{"name":"Fond national suisse de la recherche scientifique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An immunocompetent adult received corticosteroids for chest pain, which later was clinically found to be herpes zoster (HZ). She developed severe disease and rapid viral dissemination that elicited an exceptionally strong varicella zoster virus\u2013specific B-cell and CD8 T-cell response. Clinicians should consider atypical HZ presentation prior to corticosteroid administration.<\/jats:p>","DOI":"10.1093\/cid\/ciy984","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T04:14:02Z","timestamp":1546488842000},"page":"348-351","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of Virus-specific Immune Response During Varicella Zoster Virus Encephalitis in a Young Adult"],"prefix":"10.1093","volume":"69","author":[{"given":"Nicole L","family":"Sullivan","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane S","family":"Eberhardt","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia"},{"name":"Department of Pediatrics and Pathology-Immunology, Center for Vaccinology and Neonatal Immunology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Wieland","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama S","family":"Akondy","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumi","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children\u2019s Healthcare of Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita K","family":"McElroy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children\u2019s Healthcare of Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafi","family":"Ahmed","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,19]]},"reference":[{"key":"2020062906334949900_CIT0001","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s12879-015-1262-8","article-title":"Annual incidence rates of herpes zoster among an immunocompetent population in the United States","volume":"15","author":"Johnson","year":"2015","journal-title":"BMC Infect Dis"},{"key":"2020062906334949900_CIT0002","author":"Centers for Disease Control and Prevention"},{"key":"2020062906334949900_CIT0003","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.cell.2017.04.026","article-title":"Metabolic phenotypes of response to vaccination in humans","volume":"169","author":"Li","year":"2017","journal-title":"Cell"},{"key":"2020062906334949900_CIT0004","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"key":"2020062906334949900_CIT0005","doi-asserted-by":"crossref","first-page":"e1004008","DOI":"10.1371\/journal.ppat.1004008","article-title":"Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV","volume":"10","author":"Chiu","year":"2014","journal-title":"PLoS Pathog"},{"key":"2020062906334949900_CIT0006","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jpeds.2016.02.040","article-title":"Strong additional effect of a second varicella vaccine dose in children in Germany, 2009\u20132014","volume":"173","author":"Siedler","year":"2016","journal-title":"J Pediatr"},{"key":"2020062906334949900_CIT0007","article-title":"Varicella vaccine effectiveness in preventing community transmission in the 2-dose era","volume":"137: 1\u20139","author":"Perella","year":"2016","journal-title":"Pediatrics"},{"key":"2020062906334949900_CIT0008","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1073\/pnas.1502619112","article-title":"Human Ebola virus infection results in substantial immune activation","volume":"112","author":"McElroy","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020062906334949900_CIT0009","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/infdis\/jix201","article-title":"A case of human Lassa virus infection with robust acute T-cell activation and long-term virus-specific T-cell responses","volume":"215","author":"McElroy","year":"2017","journal-title":"J Infect Dis"},{"key":"2020062906334949900_CIT0010","doi-asserted-by":"crossref","first-page":"e1002367","DOI":"10.1371\/journal.ppat.1002367","article-title":"CD4 T cell immunity is critical for the control of simian varicella virus infection in a nonhuman primate model of VZV infection","volume":"7","author":"Haberthur","year":"2011","journal-title":"PLoS Pathog"},{"key":"2020062906334949900_CIT0011","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"2020062906334949900_CIT0012","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/0961203315627203","article-title":"Herpes zoster infection in childhood-onset systemic lupus erythematosus patients: a large multicenter study","volume":"25","author":"Ferreira","year":"2016","journal-title":"Lupus"},{"key":"2020062906334949900_CIT0013","first-page":"1\u201341","article-title":"Corticosteroids for preventing postherpetic neuralgia","author":"Han","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2020062906334949900_CIT0014","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMcp1302674","article-title":"Clinical practice: herpes zoster","volume":"369","author":"Cohen","year":"2013","journal-title":"N Engl J Med"},{"key":"2020062906334949900_CIT0015","article-title":"Disseminated herpes zoster causing acute respiratory distress syndrome in an immunocompetent patient","volume":"2017:bcr-2017-220542","author":"Rudinsky","year":"2017","journal-title":"BMJ Case Rep"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/69\/2\/348\/33441504\/ciy984.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/69\/2\/348\/33441504\/ciy984.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T10:34:07Z","timestamp":1593426847000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/69\/2\/348\/5295826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,19]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,19]]},"published-print":{"date-parts":[[2019,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciy984","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7,15]]},"published":{"date-parts":[[2019,1,19]]}}}