{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:14:12Z","timestamp":1790806452399,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In women seronegative before pregnancy, congenital cytomegalovirus (cCMV)-related sequelae are exclusively seen in those infected in the first trimester of pregnancy. Following a maternal primary infection in the first trimester, up to 30% of infected neonates suffer long-term sequelae. Maternal parity is an established risk factor of cCMV in previously seronegative women. Our objective was to quantify, in a population of women seronegative at their first pregnancy, the risk of cCMV and related sequelae following primary infections in the first trimester in subsequent pregnancies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>There were 739 women seronegative at their first pregnancy who had at least 1 of 971 subsequent pregnancies and deliveries managed at our institution. All women had CMV immunoglobin (Ig) G and IgM testing at 11\u201314 weeks of each pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between 2 consecutive pregnancies, 15.6% (115\/739) of women seroconverted. Of these seroconversions, 29% (33\/115) occurred in the periconceptional period or in the first trimester. The risks for cCMV and related sequelae (neurologic and\/or hearing loss) following a maternal infection in the first trimester were, respectively, 24- and 6-fold higher (risk ratios, 24 [95% confidence interval {CI}, 10.8\u201362.3] and 6 [95% CI 1.5\u201324], respectively) than in the general pregnant population. Of all primary maternal infections and fetal infections in the first trimester, 88% (29\/33) and 92% (11\/12), respectively, occurred when the inter-pregnancy interval was \u22642 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Women seronegative at their first pregnancy with a subsequent pregnancy within 2 years have the highest risk of delivering a child with cCMV-related sequelae. These women should be made aware of the risk and given the opportunity of serology screening in the first trimester.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz1067","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T19:24:22Z","timestamp":1572031462000},"page":"1598-1603","source":"Crossref","is-referenced-by-count":37,"title":["Quantifying the Burden of Congenital Cytomegalovirus Infection With Long-term Sequelae in Subsequent Pregnancies of Women Seronegative at Their First Pregnancy"],"prefix":"10.1093","volume":"71","author":[{"given":"Marianne","family":"Leruez-Ville","sequence":"first","affiliation":[{"name":"Paris Descartes University, Paris, France"},{"name":"Virology Laboratory, Reference Laboratory for Cytomegalovirus Infections, Assistance Publique-Hopitaux de Paris, Hospital Necker, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Guilleminot","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Paris, France"},{"name":"Virology Laboratory, Reference Laboratory for Cytomegalovirus Infections, Assistance Publique-Hopitaux de Paris, Hospital Necker, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Stirnemann","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Paris, France"},{"name":"Maternity, Assistance Publique-Hopitaux de Paris, Hospital Necker, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent J","family":"Salomon","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Paris, France"},{"name":"Virology Laboratory, Reference Laboratory for Cytomegalovirus Infections, Assistance Publique-Hopitaux de Paris, Hospital Necker, Paris, 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