{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:26:35Z","timestamp":1792041995720,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Texas Children\u2019s Hospital Pediatric Pilot Research Fund"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Staphylococcus aureus is the most common cause of acute hematogenous osteoarticular infections (AHOAIs) in children. The risk factors for the development of orthopedic complications (OC) after AHOAI are poorly understood. We sought to describe clinical and microbiologic variables present on the index admission that may predict OC in S. aureus AHOAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Staphylococcus aureus AHOAI cases were identified from 2011\u20132017 at Texas Children\u2019s Hospital and reviewed for the development of OC. OC included chronic osteomyelitis, growth arrest, avascular necrosis, chronic dislocation, and pathologic fracture. All S. aureus isolates were characterized by pulsed-field gel electrophoresis and agr group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 286 cases were examined of which 27 patients (9.4%) developed OC. Patients who developed OC more often had infection with an agr group III organism (P = .04), bacteremia (P = .04), delayed source control (P &amp;lt; .001), \u22652 surgical procedures (P &amp;lt; .001), intensive care unit admission (P = .09), and fever &amp;gt;4 days after admission (P = .008). There was no association with OC and patient age, methicillin resistance, or choice\/route of antibiotics. In multivariable analyses of OC, infection with agr group III S. aureus, prolonged fever, and delayed source control remained statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OC develop following S. aureus AHOAI in 9.4% of cases. Although the development of OC is likely multifactorial, agr group III organisms, prolonged fever, and delayed source control are independently associated with OC. Moreover, early aggressive surgical source control may be beneficial in children with S. aureus AHOAI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciz109","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T15:15:30Z","timestamp":1548947730000},"page":"1955-1961","source":"Crossref","is-referenced-by-count":72,"title":["Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children"],"prefix":"10.1093","volume":"69","author":[{"given":"J Chase","family":"McNeil","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus G","family":"Vallejo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y","family":"Kok","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M","family":"Sommer","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina G","family":"Hult\u00e9n","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon L","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"2020071003041855700_CIT0001","doi-asserted-by":"crossref","first-page":"e20154616","DOI":"10.1542\/peds.2015-4616","article-title":"Role of operative or interventional radiology-guided cultures for osteomyelitis","volume":"137","author":"McNeil","year":"2016","journal-title":"Pediatrics"},{"key":"2020071003041855700_CIT0002","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/01.bpo.0000242431.91489.b4","article-title":"Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus","volume":"26","author":"Arnold","year":"2006","journal-title":"J Pediatr Orthop"},{"key":"2020071003041855700_CIT0003","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/01.inf.0000133044.79130.2a","article-title":"Community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children","volume":"23","author":"Mart\u00ednez-Aguilar","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"2020071003041855700_CIT0004","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archpedi.1975.02120480007004","article-title":"Osteomyelitis in infants and children. 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