{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:51:20Z","timestamp":1793321480230,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This meta-analysis was conducted to estimate the global burden of hepatitis B virus (HBV) infection in people living with human immunodeficiency virus (PLWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched multiple databases for studies published between January 1990 and December 2017. HBV infection (hepatitis B surface antigen) was diagnosed with serological assays. A random-effects meta-analysis served to pool data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 358 studies (834 544 PLWH from 87 countries). The pooled prevalence of HBV infection was 8.4% (95% confidence interval [CI], 7.9%\u20138.8%), among which 26.8% (95% CI, 22.0%\u201331.9%) was positive to hepatitis B e antigen. HBV prevalence (with 95% CIs) differed according to region: West and Central Africa, 12.4% (11.0%\u201313.8%); Middle East and North Africa, 9.9% (6.0%\u201314.6%); Asia and the Pacific, 9.8% (8.7%\u201311.0%); Eastern and Southern Africa, 7.4% (6.4%\u20138.4%); Western and Central Europe and North America, 6.0% (5.5%\u20136.7%); and Latin America and the Caribbean, 5.1% (4.2%\u20136.2%) (P &amp;lt; .0001). The prevalence decreased from 10.4% in low-developed to 6.6% in highly developed countries (P &amp;lt; .0001) and increased from 7.3% in countries with HIV prevalence \u22641% to 9.7% in countries with HIV prevalence &amp;gt;1% (P &amp;lt; .0001). Globally, we estimated that there were 3 136 500 (95% CI, 2 952 000\u20133 284 100) cases of HBV in PLWH, with 73.8% of estimated regional cases from sub-Saharan Africa and 17.1% from Asia and the Pacific.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests a high burden of HBV infection in PLWH, with disparities according to region, level of development, and country HIV prevalence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciz1170","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T15:12:28Z","timestamp":1575645148000},"page":"2799-2806","source":"Crossref","is-referenced-by-count":93,"title":["Global Burden of Hepatitis B Infection in People Living With Human Immunodeficiency Virus: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"71","author":[{"given":"Steve","family":"Leumi","sequence":"first","affiliation":[{"name":"Biotechnology Centre, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-6279","authenticated-orcid":false,"given":"Jean Joel","family":"Bigna","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Paris-Saclay, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie A","family":"Amougou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"},{"name":"Department of Virology, Centre Pasteur of Cameroon, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Ngouo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich Flore","family":"Nyaga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques","family":"Noubiap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa"},{"name":"Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"2021010207403244300_CIT0001","volume-title":"Fact sheet\u2014latest statistics on the status of the AIDS epidemic","author":"Joint 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