{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:15:56Z","timestamp":1784139356900,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Ministry of Health","award":["PHRI-06"],"award-info":[{"award-number":["PHRI-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recurrent urinary tract infections (R-UTIs) are the main cause of morbidity and hospitalizations in subjects with neurogenic bladder (NB) due to spinal cord injury (SCI). We evaluated the efficacy of weekly oral cyclic antibiotic (WOCA) prophylaxis (ie, the alternate weekly administration of 2 antibiotics) in preventing R-UTIs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Randomized (1:1), open-label, superiority-controlled trial compared WOCA prophylaxis to no prophylaxis (control) for 6 months in patients with NB due to SCI, using clean intermittent self-catheterization, and suffering from R-UTIs. Primary outcome was incidence of symptomatic antibiotic-treated UTIs. Secondary outcomes were number of febrile UTIs, number of hospitalizations, WOCA tolerance, antibiotic consumption, number of negative urine cultures, and emergence of bacterial resistance in urinary, intestinal, and nasal microbiota.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-five patients were either allocated to the WOCA group (n = 23) or the control group (n = 22). Median (IQR) incidence of symptomatic antibiotic-treated UTIs was 1.0 (0.5\u20132.5) in the WOCA group versus 2.5 (1.2\u20134.0) (P = .0241) in the control group. No febrile UTIs were recorded in the WOCA group versus 9 (45.0%) (P &amp;lt; .001) in the control group. The median number of additional antibiotic treatment was 0.0 (IQR, 0.0\u20132.0) versus 3.0 (2.0\u20135.0) (P = .004) in the WOCA and control groups, respectively. Only few adverse events were reported. No impact on emergence of bacterial resistance was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>WOCA is efficient and well tolerated in preventing R-UTIs in SCI patients. In our study, we did not observe any emergence of antibiotic resistance in digestive and nasal microbiological cultures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT01388413.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz1207","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T20:16:49Z","timestamp":1576613809000},"page":"3128-3135","source":"Crossref","is-referenced-by-count":24,"title":["Weekly Sequential Antibioprophylaxis for Recurrent Urinary Tract Infections Among Patients With Neurogenic Bladder: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"71","author":[{"given":"Aur\u00e9lien","family":"Dinh","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Raymond Poincar\u00e9 University Hospital, Assistance Publique H\u00f4pitaux de Paris, Versailles Saint-Quentin University, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Charlotte","family":"Hallouin-Bernard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bretonneau University Hospital, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Davido","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Raymond Poincar\u00e9 University Hospital, Assistance Publique H\u00f4pitaux de Paris, Versailles Saint-Quentin University, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Lemaignen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bretonneau University Hospital, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Bouchand","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Raymond Poincar\u00e9 University Hospital, Assistance Publique H\u00f4pitaux de Paris, Versailles Saint-Quentin University, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Duran","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Raymond Poincar\u00e9 University Hospital, Assistance Publique H\u00f4pitaux de Paris, Versailles Saint-Quentin University, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Even","sequence":"additional","affiliation":[{"name":"Department of Urology, Raymond Poincar\u00e9 University Hospital, Assistance Publique H\u00f4pitaux de Paris, Versailles Saint-Quentin University, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Denys","sequence":"additional","affiliation":[{"name":"Department of Urology, Raymond Poincar\u00e9 University Hospital, Assistance Publique H\u00f4pitaux de Paris, Versailles Saint-Quentin University, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Perrouin-Verbe","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Saint-Jacques Hospital, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Sotto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Caremeau University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Caremeau University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Bruy\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Urology, Bretonneau University Hospital, Tours, 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