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This is an important cause of hospitalization among Plasmodium vivax\u2013infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100\u2009000 primaquine users.<\/jats:p>","DOI":"10.1093\/cid\/ciz122","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T15:40:36Z","timestamp":1549381236000},"page":"1440-1442","source":"Crossref","is-referenced-by-count":50,"title":["Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-3763","authenticated-orcid":false,"given":"Jose Diego","family":"Brito-Sousa","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Brazil"},{"name":"Escola Superior de Ci\u00eancias da Sa\u00fade, Universidade do Estado do Amazonas, Manaus, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalie 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Val","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Brazil"},{"name":"Escola Superior de Ci\u00eancias da Sa\u00fade, Universidade do Estado do Amazonas, Manaus, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 M","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a C","family":"Alecrim","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quique","family":"Bassat","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, University of Barcelona, Spain"},{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a, Maputo, Mozambique"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, Spain"},{"name":"Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de D\u00e9u, University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V G","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Brazil"},{"name":"Instituto de Pesquisas Le\u00f4nidas e Maria Deane, Funda\u00e7\u00e3o Oswaldo Cruz, Manaus, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuelton M","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Brazil"},{"name":"Escola Superior de Ci\u00eancias da Sa\u00fade, Universidade do Estado do Amazonas, Manaus, 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