{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:56:20Z","timestamp":1781088980157,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","award":["2016-I2M-3\u2013021"],"award-info":[{"award-number":["2016-I2M-3\u2013021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antimicrobial resistance to Neisseria gonorrhoeae has emerged for each of the antibiotics recommended as first-line therapies following their introduction into clinical practice. To improve rational and effective clinical antibiotic treatment, we analyzed the prescription patterns of antibiotics and their therapeutic effect in the treatment of uncomplicated gonorrhea in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained data from a follow-up multicenter surveillance program. Multinomial logistic regression analyses were conducted to explore the associations between demographic\/clinical variables with the levels of sensitivity to ceftriaxone and prescription of high-dose ceftriaxone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, 1686 patients infected with N. gonorrhoeae were recruited in a surveillance network during 1 January 2013 through 31 December 2017 in 7 hospitals distributed in 5 provinces. The prevalence of isolates with decreased susceptibility to ceftriaxone was 9.8% (131\/1333), fluctuating between 5.6% and 12.1%. Injectable ceftriaxone was chosen as the first-line treatment among 83.1% of patients, and most of them (72.7% [1018\/1401]) received &amp;gt;1000 mg dosage. Patients who were previously infected with gonorrhea or other sexually transmitted infections (adjusted odds ratio [AOR], 1.618 [95% confidence interval {CI}, 1.11\u20132.358]; AOR, 2.08 [95% CI, 1.41\u20133.069]) or who already used antibiotics for this infection (AOR, 1.599 [95% CI, 1.041\u20132.454]) were associated with a higher prescribed ceftriaxone dosage. All of the patients recruited in this study were cured regardless of the isolates\u2019 susceptibility to ceftriaxone or the dosage of ceftriaxone they received.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No ceftriaxone treatment failure for uncomplicated gonorrhea was reported in China; however, high-dose ceftriaxone was widely used in China. Its impacts need further study.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciz170","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:51:25Z","timestamp":1551228685000},"page":"99-105","source":"Crossref","is-referenced-by-count":33,"title":["Widespread Use of High-dose Ceftriaxone Therapy for Uncomplicated Gonorrhea Without Reported Ceftriaxone Treatment Failure: Results From 5 Years of Multicenter Surveillance Data in China"],"prefix":"10.1093","volume":"70","author":[{"given":"Yan","family":"Han","sequence":"first","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"National Center for Sexually Transmitted Disease (STD) Control, Chinese Center for Disease Control and Prevention, Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"National Center for Sexually Transmitted Disease (STD) Control, Chinese Center for Disease Control and Prevention, Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqin","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"National Center for Sexually Transmitted Disease (STD) Control, Chinese Center for Disease Control and Prevention, Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"National Center for Sexually Transmitted Disease (STD) Control, Chinese Center for Disease Control and Prevention, Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University"},{"name":"Guangdong Provincial Dermatology Hospital, Guangzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangyong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Guangxi Autonomous Region, Nanning"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhong","sequence":"additional","affiliation":[{"name":"Hainan Provincial Center for STD\/Skin Disease Control and Prevention, Haikou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Cao","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University"},{"name":"Guangdong Provincial Dermatology Hospital, Guangzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhou","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangmen Dermatology Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liufeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Tianjin Center for Disease Control and Prevention, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishan","family":"Feng","sequence":"additional","affiliation":[{"name":"Jiangmen Dermatology Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical 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