{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:43:30Z","timestamp":1791319410462,"version":"4.3.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100004107","name":"Sabin Vaccine Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In 2011, Argentina experienced its highest pertussis incidence and mortality rates of the last decade; 60% of deaths were among infants aged &amp;lt;2 months. In response, a dose of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine was recommended for all pregnant women at \u226520 weeks of gestation. Although recent studies suggest that maternal Tdap vaccination is effective at preventing infant disease, no data have come from low- or middle-income countries, nor from ones using whole-cell pertussis vaccines for primary immunization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a matched case-control evaluation to assess the effectiveness of maternal Tdap vaccination in preventing pertussis among infants aged &amp;lt;2 months in Argentina. Pertussis case patients identified from September 2012 to March 2016 at 6 hospital sites and confirmed by polymerase chain reaction testing were included. Five randomly selected controls were matched to each case patient by hospital site and mother\u2019s health district. We used multivariable conditional logistic regression to calculate odds ratios (ORs). Vaccine effectiveness (VE) was estimated as (1 \u2013 OR) \u00d7 100%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-one case patients and 300 controls were included in the analysis. Forty-nine percent of case patients and 78% of controls had mothers who were vaccinated during pregnancy. Overall Tdap VE was estimated at 80.7% (95% confidence interval, 52.1%\u201392.2%). We found similar VE whether Tdap was administered during the second or third trimester.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Tdap vaccination during pregnancy is effective in preventing pertussis in infants aged &amp;lt;2 months in Argentina, with similar effectiveness whether administered during the second or third trimester of pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz217","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T12:11:46Z","timestamp":1552651906000},"page":"380-387","source":"Crossref","is-referenced-by-count":40,"title":["Maternal Vaccination in Argentina: Tetanus, Diphtheria, and Acellular Pertussis Vaccine Effectiveness During Pregnancy in Preventing Pertussis in Infants &amp;lt;2 Months of Age"],"prefix":"10.1093","volume":"70","author":[{"given":"Viviana","family":"Romanin","sequence":"first","affiliation":[{"name":"Direcci\u00f3n de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Naci\u00f3n , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M","family":"Acosta","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Valle","family":"Juarez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Naci\u00f3n , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Briere","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella Maris","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Hospital del Ni\u00f1o Jes\u00fas , Tucum\u00e1n, Salta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Lopez","family":"Cordoba","sequence":"additional","affiliation":[{"name":"Hospital P\u00fablico Materno Infantil , Salta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Sevilla","sequence":"additional","affiliation":[{"name":"Hospital \u201cP. de Elizalde ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Florencia","family":"Lucion","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os \u201cR. Guti\u00e9rrez,\u201d Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahi","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Hospital \u201cDr. H. Heller,\u201d Neuqu\u00e9n,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sagradini","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Naci\u00f3n , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami H","family":"Skoff","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Vizzotti","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Naci\u00f3n , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,16]]},"reference":[{"key":"2024111411405584300_CIT0001","first-page":"413","article-title":"Epidemiological situation of pertussis and strategies to control it: Argentina, 2002\u20132011","volume":"112","author":"Romanin","year":"2014","journal-title":"Arch Argent Pediatr"},{"key":"2024111411405584300_CIT0002","unstructured":"Direccion de Control de Enfermedades Inmunoprevenibles\/Ministerio de Salud de la Naci\u00f3n Argentina. Calendario Nacional de Vacunaci\u00f3n 2017. Available at: http:\/\/www.msal.gob.ar\/index.php\/programas-y-planes\/184-calendario-nacional-de-vacunacion-2016. Accessed 7 November 2017."},{"key":"2024111411405584300_CIT0003","unstructured":"Programa Nacional de Control de Enfermedades Inmunoprevenibles\/Ministerio de Salud de la Naci\u00f3n Argentina. Fundamentos de la vacunacion de mujeres embarazadas con vacuna triple bacteriana acelular (dTpa). Available at: http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000000439cnt-2011-10_lineamientos-vacuna-dTpa-embarazadas.pdf. Accessed 7 November 2017."},{"key":"2024111411405584300_CIT0004","author":"Programa Nacional de Control de Enfermedades Inmunoprevenibles\/Ministerio de Salud de la Naci\u00f3n Argentina"},{"key":"2024111411405584300_CIT0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6702a1","article-title":"Prevention of pertussis, tetanus, and diphtheria with vaccines in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"67","author":"Liang","year":"2018","journal-title":"MMWR Recomm Rep"},{"key":"2024111411405584300_CIT0006","unstructured":"Pharmaceutical Management Agency. Decision to amend the diphtheria, pertussis and tetanus vaccine (Boostrix) listing. Available at: http:\/\/www.pharmac.govt.nz\/2012\/12\/12\/Notification%20of%20pertussis%20vaccination%20decision.pdf. Accessed 17 November 2018."},{"key":"2024111411405584300_CIT0007","unstructured":"Joint Committee on Vaccination and Immunisation. Teleconference minutes. Available at: http:\/\/webarchive.nationalarchives.gov.uk\/20130402161514\/http:\/\/transparency.dh.gov.uk\/2012\/09\/28\/jcvi-pertussis\/. Accessed 17 November 2018."},{"key":"2024111411405584300_CIT0008","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw529","article-title":"Global childhood deaths from pertussis: a historical review","volume":"63","author":"Chow","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2024111411405584300_CIT0009","article-title":"The epidemiology of nationally reported pertussis in the United States, 2000\u20132016 [manuscript published online ahead of print 30 August 2018]","author":"Skoff","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2024111411405584300_CIT0010","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(14)60686-3","article-title":"Effectiveness of maternal pertussis vaccination in England: an observational study","volume":"384","author":"Amirthalingam","year":"2014","journal-title":"Lancet"},{"key":"2024111411405584300_CIT0011","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-4091","article-title":"Effectiveness of vaccination during pregnancy to prevent infant pertussis","volume":"139","author":"Baxter","year":"2017","journal-title":"Pediatrics"},{"key":"2024111411405584300_CIT0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/cid\/ciw634","article-title":"Effectiveness of prenatal versus postpartum tetanus, diphtheria, and acellular pertussis vaccination in preventing infant pertussis","volume":"64","author":"Winter","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2024111411405584300_CIT0013","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2017.22.22.30545","article-title":"A case-control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016","volume":"22","author":"Bellido-Blasco","year":"2017","journal-title":"Euro Surveill"},{"key":"2024111411405584300_CIT0014","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/cid\/cix724","article-title":"Impact of the US maternal tetanus, diphtheria, and acellular pertussis vaccination program on preventing pertussis in infants &lt;2 months of age: a case-control evaluation","volume":"65","author":"Skoff","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2024111411405584300_CIT0015","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.vaccine.2018.02.047","article-title":"Effectiveness of maternal pertussis vaccination in preventing infection and disease in infants: the NSW Public Health Network case-control study","volume":"36","author":"Saul","year":"2018","journal-title":"Vaccine"},{"key":"2024111411405584300_CIT0016","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/cid\/ciu821","article-title":"A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012\u20132013","volume":"60","author":"Dabrera","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2024111411405584300_CIT0017","unstructured":"Programa Nacional de Control de Enfermedades Inmunoprevenibles\/Ministerio de Salud de la Naci\u00f3n Argentina. Coqueluche: recomendaciones y definiciones. Available at: http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000000473cnt-2013-10_coqueluche-recomendaciones-definiciones.pdf. Accessed 7 November 2017."},{"key":"2024111411405584300_CIT0018","unstructured":"Ministerio de Salud de la Naci\u00f3n. Coqueluche sospechoso y coqueluche en estudios de contactos: normativa y tutorial para la vigilancia a traves del Sistema Nacional de Vigilancia Laboratorial SIVILA-SNVS. Available at: http:\/\/www.msal.gob.ar\/images\/stories\/epidemiologia\/vigilancia\/sivila\/tutoriales\/coqueluche-tutorial-normativa-para-notificacion-sivila-2011.pdf. 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