{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:42:32Z","timestamp":1782823352747,"version":"3.54.5"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["6110-00596B"],"award-info":[{"award-number":["6110-00596B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A reduced, 2-dose schedule of human papillomavirus (HPV) vaccination has been endorsed for preadolescent women on the basis of immunogenicity data from randomized trials, and limited data suggest that even 1 dose may provide sufficient protection. Surveillance of the impact of &amp;lt;3 vaccine doses on clinical endpoints in the targeted age group is warranted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a nationwide cohort study of all women aged 17\u201325 years, living in Denmark between 2006 and 2016. From nationwide registries, we extracted individual-level data on vaccination with the quadrivalent HPV (qHPV) vaccine at 16 years or younger, number of doses administered, diagnoses of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) or grade 3 or worse (CIN3+), and potential confounders. Using Poisson regression, we estimated incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for CIN2+ and CIN3+, according to vaccination status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The cohort comprised 590 083 women, of which 215 309 (36%) women were vaccinated at \u226416 years, and among these, 40 742 (19%) received &amp;lt;3 vaccine doses. A total of 5561 women had a diagnosis of CIN3+. We found considerable vaccine effectiveness against CIN3+ after 1 (IRR, 0.38 [95% CI, .14\u2013.98]), 2 (IRR, 0.38 [95% CI, .22\u2013.66]), or 3 (IRR, 0.37 [95% CI, .30\u2013.45]) vaccine doses, compared to unvaccinated women. Results were similar for CIN2+.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We find substantial effectiveness of qHPV vaccination against high-grade cervical precancerous lesions, among women vaccinated with 1, 2, or 3 doses at \u226416 years of age. One-dose vaccination appeared to provide similar protection as 3-dose vaccination.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz239","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T21:06:36Z","timestamp":1553029596000},"page":"608-614","source":"Crossref","is-referenced-by-count":40,"title":["Dose-related Effectiveness of Quadrivalent Human Papillomavirus Vaccine Against Cervical Intraepithelial Neoplasia: A Danish Nationwide Cohort Study"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-697X","authenticated-orcid":false,"given":"Freija","family":"Verdoodt","sequence":"first","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center"},{"name":"Department of Gynaecology, Rigshospitalet, University of Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"2024111411405854000_CIT0001","first-page":"465","article-title":"Human papillomavirus vaccines: WHO position paper","volume":"89","author":"World Health Organization (WHO)","year":"2014","journal-title":"Wkly Epidemiol Rec"},{"key":"2024111411405854000_CIT0002","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1016\/j.vaccine.2017.12.079","article-title":"Explanations for the high potency of HPV prophylactic 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