{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:59:26Z","timestamp":1792519166356,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>18F-fluorodeoxyglucose positron emission tomography\/computed tomography (18F-FDG-PET\/CT) has emerged as a useful diagnostic tool for suspected infective endocarditis (IE) in patients with prosthetic valves or implantable devices. However, there is limited evidence regarding use of 18F-FDG-PET\/CT for the diagnosis of native valve endocarditis (NVE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between 2014 and 2017, 303 episodes of left-sided suspected IE (188 prosthetic valves\/ascending aortic prosthesis and 115 native valves) were studied. 18F-FDG-PET\/CT accuracy was determined in the subgroups of patients with NVE and prosthetic valve endocarditis (PVE)\/ascending aortic prosthesis infection (AAPI). Associations between inflammatory infiltrate patterns and 18F-FDG-PET\/CT uptake were investigated in an exploratory ad hoc histological analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 188 patients with PVE\/AAPI, the sensitivity, specificity, and positive and negative predictive values of 18F-FDG-PET\/CT focal uptake were 93%, 90%, 89%, and 94%, respectively, while among 115 patients with NVE, the corresponding values were 22%, 100%, 100%, and 66%. The inclusion of abnormal 18F-FDG cardiac uptake as a major criterion at admission enabled a recategorization of 76% (47\/62) of PVE\/AAPI cases initially classified as \u201cpossible\u201d to \u201cdefinite\u201d IE. In the histopathological analysis, a predominance of polymorphonuclear cell inflammatory infiltrate and a reduced extent of fibrosis were observed in the PVE group only.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Use of 18F-FDG-PET\/CT at the initial presentation of patients with suspected PVE increases the diagnostic capability of the modified Duke criteria. In patients who present with suspected NVE, the use of 18F-FDG-PET\/CT is less accurate and could only be considered a complementary diagnostic tool for a specific population of patients with NVE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz267","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T21:03:14Z","timestamp":1553720594000},"page":"583-594","source":"Crossref","is-referenced-by-count":70,"title":["The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography in the Diagnosis of Left-sided Endocarditis: Native vs Prosthetic Valves Endocarditis"],"prefix":"10.1093","volume":"70","author":[{"given":"Raphael Abeg\u00e3o","family":"de Camargo","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Sommer Bitencourt","sequence":"additional","affiliation":[{"name":"Center for Clinical and Epidemiological Research, University Hospital, University of S\u00e3o Paulo School of Medicine ,","place":["Brazil"]},{"name":"Hospital Israelinta Albert Einstein, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Claudio","family":"Meneghetti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Department, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jose","family":"Soares","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Department, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Fernando Tonello","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Department, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Ribeiro","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Valvular Heart Disease Unit, University of S\u00e3o Paulo Medical School ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Francesconi","family":"Felicio","sequence":"additional","affiliation":[{"name":"Infection Control Team, University of S\u00e3o Paulo Medical School 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