{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:29:47Z","timestamp":1787657387928,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Swiss Tropical and Public Health Institute"},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["614739"],"award-info":[{"award-number":["614739"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Preventive chemotherapy is the main strategy to control soil-transmitted helminth (STH) infections. Albendazole and mebendazole are ubiquitously used, but they are not sufficiently effective against Trichuris trichiura. Moxidectin might be a useful addition to the small drug armamentarium. However, the optimal dosage of moxidectin alone and in combination with albendazole against T. trichiura and other STHs has not yet been determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A Phase II, randomized, placebo-controlled, dose-finding trial was conducted in 2 secondary schools on Pemba Island, Tanzania. Using a computer-generated list, T. trichiura\u2013infected adolescents were randomly assigned to 7 treatment arms: 8, 16, or 24 mg of moxidectin monotherapy; 8, 16, or 24 mg of moxidectin plus 400 mg of albendazole combination therapy; or placebo. The primary outcome was cure rate (CR) against T. trichiura, analyzed 13 to 20 days after treatment by quadruple Kato-Katz thick smears.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 290 adolescents were enrolled (41 or 42 per arm). CRs against T. trichiura were 43, 46, and 44% for 8, 16, and 24 mg of moxidectin alone, respectively; 60, 62, and 66% for the same moxidectin dosages plus 400 mg of albendazole, respectively; and 12% for placebo. The moxidectin-albendazole arms also revealed higher CRs and egg reduction rates against hookworm than the monotherapy arms. Moxidectin and its combination with albendazole were well tolerated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Moxidectin-albendazole is superior to moxidectin. There is no benefit of using doses above 8 mg, which is the recommended dose for onchocerciasis. The moxidectin-albendazole combination of 8 mg plus 400 mg should be investigated further to develop recommendations for appropriate control of STH infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT03501251.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz326","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:08:40Z","timestamp":1555931320000},"page":"1193-1201","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against <i>Trichuris trichiura<\/i> in Adolescents: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"70","author":[{"given":"Ladina","family":"Keller","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute , Basel,","place":["Switzerland"]},{"name":"University of Basel , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta S","family":"Palmeirim","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute , Basel,","place":["Switzerland"]},{"name":"University of Basel , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaali M","family":"Ame","sequence":"additional","affiliation":[{"name":"Public Health Laboratory Ivo de Carneri , Chake Chake,","place":["Republic of Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said M","family":"Ali","sequence":"additional","affiliation":[{"name":"Public Health Laboratory Ivo de Carneri , Chake Chake,","place":["Republic of Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Puchkov","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Huwyler","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hattendorf","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute , Basel,","place":["Switzerland"]},{"name":"University of Basel , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute , Basel,","place":["Switzerland"]},{"name":"University of Basel , 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