{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:25:32Z","timestamp":1784867132739,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["2R01HD061959-07A2"],"award-info":[{"award-number":["2R01HD061959-07A2"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/06579-0"],"award-info":[{"award-number":["2013\/06579-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The exact contribution of congenital cytomegalovirus infection (cCMVI) to permanent hearing loss (HL) in highly seropositive populations is unknown. We determined the contribution of cCMVI to HL and estimated the effectiveness of newborn hearing screening (HS) in identifying neonates with CMV-related HL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 11 900 neonates born from a population with \u226597% maternal seroprevalence were screened for cCMVI and HL. cCMVI was confirmed by detection of CMV-DNA in saliva and urine at age &amp;lt;3 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 68 (0.6%; 95% confidence interval [CI], 0.4\u20130.7) neonates were identified with cCMVI. Of the 91 (0.8%) newborns who failed the HS, 24 (26.4%) were confirmed with HL, including 7 (29.2%; 95% CI, 17.2\u201359.3) with cCMVI. Another newborn with cCMVI passed the HS but was confirmed with HL at age 21 days. Of the 62 neonates with cCMVI who underwent a complete hearing evaluation, 8 (12.9%; 95% CI, 6.7\u201323.4) had HL and most (7\/8; 87.5%; 95% CI, 46.6\u201399.7) were identified by HS. The rate of CMV-related HL was 8 per 11 887 neonates (0.7 per 1000 live births). The prevalence ratio of HL among neonates with cCMVI compared to CMV-uninfected neonates was 89.5 (95% CI, 39.7\u2013202.0). No late-onset cCMVI-related HL was detected during a median follow-up of 36 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>cCMVI is an important cause of HL in childhood in all settings. Integrating targeted cCMVI screening among neonates who fail a HS could be a reasonable, cost-effective strategy to identify newborns with early-onset cCMVI-related HL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciz413","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T15:16:20Z","timestamp":1558019780000},"page":"1379-1384","source":"Crossref","is-referenced-by-count":35,"title":["Contribution of Congenital Cytomegalovirus Infection to Permanent Hearing Loss in a Highly Seropositive Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study"],"prefix":"10.1093","volume":"70","author":[{"given":"Aparecida Y","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Otorhinolaryngology, and Head and Neck Surgery, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana R 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Otorhinolaryngology, and Head and Neck Surgery, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M S","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Otorhinolaryngology, and Head and Neck Surgery, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Carnevale-Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Otorhinolaryngology, and Head and Neck Surgery, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen B","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama School of Medicine , Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh B","family":"Boppana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama School of Medicine , Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Britt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama School of Medicine , Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa M","family":"Mussi-Pinhata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Otorhinolaryngology, and Head and Neck Surgery, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , 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