{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:34:18Z","timestamp":1781350458537,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"Supplement_6","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPPGH5231"],"award-info":[{"award-number":["OPPGH5231"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1127988"],"award-info":[{"award-number":["OPP1127988"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1201031"],"award-info":[{"award-number":["OPP1201031"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is a major global health concern, yet, there are noticeable gaps in AMR surveillance data in regions such as sub-Saharan Africa. We aimed to measure the prevalence of extended-spectrum \u03b2-lactamase (ESBL) producing Gram-negative bacteria in bloodstream infections from 12 sentinel sites in sub-Saharan Africa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were generated during the Typhoid Fever Surveillance in Africa Program (TSAP), in which standardized blood cultures were performed on febrile patients attending 12 health facilities in 9 sub-Saharan African countries between 2010 and 2014. Pathogenic bloodstream isolates were identified at the sites and then subsequently confirmed at a central reference laboratory. Antimicrobial susceptibility testing, detection of ESBL production, and conventional multiplex polymerase chain reaction (PCR) testing for genes encoding for \u03b2-lactamase were performed on all pathogens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five hundred and five pathogenic Gram-negative bloodstream isolates were isolated during the study period and available for further characterization. This included 423 Enterobacteriaceae. Phenotypically, 61 (12.1%) isolates exhibited ESBL activity, and genotypically, 47 (9.3%) yielded a PCR amplicon for at least one of the screened ESBL genes. Among specific Gram-negative isolates, 40 (45.5%) of 88 Klebsiella spp., 7 (5.7%) of 122 Escherichia coli, 6 (16.2%) of 37 Acinetobacter spp., and 2 (1.3%) of 159 of nontyphoidal Salmonella (NTS) showed phenotypic ESBL activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings confirm the presence of ESBL production among pathogens causing bloodstream infections in sub-Saharan Africa. With few alternatives for managing ESBL-producing pathogens in the African setting, measures to control the development and proliferation of AMR organisms are urgently needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz450","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T23:24:46Z","timestamp":1568071486000},"page":"S449-S458","source":"Crossref","is-referenced-by-count":25,"title":["Multicountry Distribution and Characterization of Extended-spectrum \u03b2-Lactamase\u2013associated Gram-negative Bacteria From Bloodstream Infections in Sub-Saharan Africa"],"prefix":"10.1093","volume":"69","author":[{"given":"Trevor","family":"Toy","sequence":"first","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Deok","family":"Pak","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung Pham","family":"Duc","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I","family":"Campbell","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna Ahmed","family":"El Tayeb","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Gezira, Wad Medani, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Von Kalckreuth","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Im","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Panzner","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Maria","family":"Cruz Espinoza","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Eibach","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Myriam","family":"Dekker","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"},{"name":"German Center for Infection Research, Hamburg-Borstel-Lu\u0308beck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Eun","family":"Park","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-4574","authenticated-orcid":false,"given":"Hyon Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"},{"name":"Department of Medicine, Cambridge University, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Konings","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondari D","family":"Mogeni","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"},{"name":"Kenya Medical Research Institute-Centre for Global Health Research (KEMRI-CGHR), Nairobi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Cosmas","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, KEMRI Complex, Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Bjerregaard-Andersen","sequence":"additional","affiliation":[{"name":"Bandim Health Project, Bissau, Guinea-Bissau"},{"name":"Research Center for Vitamins and Vaccines, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagla","family":"Gasmelseed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Gezira, Wad Medani, Sudan"},{"name":"Faculty of Science, University of Hafr Al Batin, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian T","family":"Hertz","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical Centre, Moshi, Tanzania"},{"name":"Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Krumkamp","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Ley","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"},{"name":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamala","family":"Thriemer","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"},{"name":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon Parfait","family":"Kabore","sequence":"additional","affiliation":[{"name":"Schiphra Hospital, Ouagadougou, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissatou","family":"Niang","sequence":"additional","affiliation":[{"name":"Institute Pasteur de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiana Mirana","family":"Raminosoa","sequence":"additional","affiliation":[{"name":"University of Antananarivo, Antananarivo, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Sampo","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur des Sciences de la Population, University of Ouagadougou, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimako","family":"Sarpong","sequence":"additional","affiliation":[{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdramane","family":"Soura","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur des Sciences de la Population, University of Ouagadougou, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellis","family":"Owusu-Dabo","sequence":"additional","affiliation":[{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Ghana"},{"name":"Department of Global and International Health, School of Public Health, KNUST, Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekonnen","family":"Teferi","sequence":"additional","affiliation":[{"name":"Armauer Hansen Research Institute, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biruk","family":"Yeshitela","sequence":"additional","affiliation":[{"name":"Armauer Hansen Research Institute, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Poppert","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"May","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"},{"name":"German Center for Infection Research, Hamburg-Borstel-Lu\u0308beck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome H","family":"Kim","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chon","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abroaham","family":"Aseffa","sequence":"additional","affiliation":[{"name":"Armauer Hansen Research Institute, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"Breiman","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Centre for Global Health Research (KEMRI-CGHR), Nairobi"},{"name":"Global Health Institute, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Sch\u00fctt-Gerowitt","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"},{"name":"Institute of Medical Microbiology, University of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Aaby","sequence":"additional","affiliation":[{"name":"Bandim Health Project, Bissau, Guinea-Bissau"},{"name":"Research Center for Vitamins and Vaccines, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw","family":"Adu-Sarkodie","sequence":"additional","affiliation":[{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Ghana"},{"name":"Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Crump","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical Centre, Moshi, Tanzania"},{"name":"Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina"},{"name":"Duke Global Health Institute, Duke University, Durham, North Carolina"},{"name":"Centre for International Health, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Rakotozandrindrainy","sequence":"additional","affiliation":[{"name":"University of Antananarivo, Antananarivo, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Eberhard-Karls University T\u00fcbingen, Germany"},{"name":"Duy Tan University, Da Nang, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Gassama","family":"Sow","sequence":"additional","affiliation":[{"name":"Institute Pasteur de Dakar, Senegal"},{"name":"Universit\u00e9 Cheikh Anta Diop de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Clemens","sequence":"additional","affiliation":[{"name":"International Centre for Diarrheal Disease Research, Dhaka, Bangladesh"},{"name":"University of California, Fielding School of Public Health, Los Angeles"},{"name":"School of Medicine, Korea University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Wierzba","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"},{"name":"Department of Medicine, Cambridge University, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Marks","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, Seoul, South Korea"},{"name":"Department of Medicine, Cambridge University, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2019103013455335900_CIT0001"},{"key":"2019103013455335900_CIT0002","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1586\/14787210.6.5.751","article-title":"Clinical and economic burden of antimicrobial resistance","volume":"6","author":"Maragakis","year":"2008","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2019103013455335900_CIT0003","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: a clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"2019103013455335900_CIT0004","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijid.2018.01.011","article-title":"Global forecast of antimicrobial resistance in invasive isolates of Escherichia coli and Klebsiella pneumoniae","volume":"68","author":"Alvarez-Uria","year":"2018","journal-title":"Int J Infect Dis"},{"key":"2019103013455335900_CIT0005","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/jac\/dkx146","article-title":"Global epidemiology of CTX-M \u03b2-lactamases: temporal and geographical shifts in genotype","volume":"72","author":"Bevan","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2019103013455335900_CIT0006","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/MOP.0000000000000182","article-title":"The contribution of extended-spectrum \u03b2-lactamases to multidrug-resistant infections in children","volume":"27","author":"Murray","year":"2015","journal-title":"Curr Opin Pediatr"},{"key":"2019103013455335900_CIT0007","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2019103013455335900_CIT0008","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/jac\/dks301","article-title":"Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to Enterobacteriaceae producing extended-spectrum \u03b2-lactamases: a systematic review and meta-analysis","volume":"67","author":"Vardakas","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"2019103013455335900_CIT0009","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1016\/S2214-109X(17)30022-0","article-title":"Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study","volume":"5","author":"Marks","year":"2017","journal-title":"Lancet Glob Health"},{"key":"2019103013455335900_CIT0010","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/cid\/civ693","article-title":"The Typhoid Fever Surveillance in Africa Program (TSAP): clinical, diagnostic, and epidemiological methodologies","volume":"62","author":"von Kalckreuth","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2019103013455335900_CIT0011","volume-title":"Performance standards for antimicrobial susceptibility testing: Twenty-sixth informational supplement","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2016"},{"key":"2019103013455335900_CIT0012","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases","volume":"57","author":"Woodford","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"2019103013455335900_CIT0013","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.jinf.2007.07.017","article-title":"Detection of CTX-M-14 extended-spectrum beta-lactamase in Shigella sonnei isolates from China","volume":"55","author":"Xiong","year":"2007","journal-title":"J Infect"},{"key":"2019103013455335900_CIT0014","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jac\/dkp498","article-title":"Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae","volume":"65","author":"Dallenne","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2019103013455335900_CIT0015","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1128\/JCM.40.6.2153-2162.2002","article-title":"Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR","volume":"40","author":"P\u00e9rez-P\u00e9rez","year":"2002","journal-title":"J Clin Microbiol"},{"key":"2019103013455335900_CIT0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.46.1.1-11.2002","article-title":"Plasmid-determined AmpC-type beta-lactamases","volume":"46","author":"Philippon","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"2019103013455335900_CIT0017","doi-asserted-by":"crossref","first-page":"e0171216","DOI":"10.1371\/journal.pone.0171216","article-title":"Prevalence of ESBL-producing Enterobacteriaceae in pediatric bloodstream infections: a systematic review and meta-analysis","volume":"12","author":"Flokas","year":"2017","journal-title":"PLoS One"},{"key":"2019103013455335900_CIT0018","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1476-0711-12-28","article-title":"Antimicrobial resistance in human and animal pathogens in Zambia, Democratic Republic of Congo, Mozambique, and Tanzania: an urgent need of a sustainable surveillance system","volume":"12","author":"Mshana","year":"2013","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2019103013455335900_CIT0019","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/jac\/dkt500","article-title":"Proportion of extended-spectrum \u03b2-lactamase (ESBL)-producing isolates among Enterobacteriaceae in Africa: evaluation of the evidence\u2013systematic review","volume":"69","author":"Tansarli","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"2019103013455335900_CIT0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijmm.2016.05.006","article-title":"Extended spectrum beta-lactamase producing Enterobacteriaceae causing bloodstream infections in rural Ghana, 2007\u20132012","volume":"306","author":"Eibach","year":"2016","journal-title":"Int J Med Microbiol"},{"key":"2019103013455335900_CIT0021","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1469-0691.2007.01867.x","article-title":"The spread of CTX-M-type extended-spectrum beta-lactamases","volume":"14","author":"Rossolini","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"2019103013455335900_CIT0022","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1756-0500-3-116","article-title":"Clinical outcome of empiric antimicrobial therapy of bacteremia due to extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae","volume":"3","author":"Chaubey","year":"2010","journal-title":"BMC Res Notes"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/69\/Supplement_6\/S449\/30328155\/ciz450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/69\/Supplement_6\/S449\/30328155\/ciz450.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T15:25:24Z","timestamp":1572449124000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/69\/Supplement_6\/S449\/5609447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":22,"journal-issue":{"issue":"Supplement_6","published-online":{"date-parts":[[2019,10,30]]},"published-print":{"date-parts":[[2019,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciz450","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11,15]]},"published":{"date-parts":[[2019,10,30]]}}}