{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:52:56Z","timestamp":1792511576532,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bacterial meningitis is a major cause of mortality among children under 5 years of age. Senegal is part of World Health Organization\u2013coordinated sentinel site surveillance for pediatric bacterial meningitis surveillance. We conducted this analysis to describe the epidemiology and etiology of bacterial meningitis among children less than 5 years in Senegal from 2010 and to 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children who met the inclusion criteria for suspected meningitis at the Centre Hospitalier National d\u2019Enfants Albert Royer, Senegal, from 2010 to 2016 were included. Cerebrospinal fluid specimens were collected from suspected cases examined by routine bacteriology and molecular assays. Serotyping, antimicrobial susceptibility testing, and whole-genome sequencing were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1013 children were admitted with suspected meningitis during the surveillance period. Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus accounted for 66% (76\/115), 25% (29\/115), and 9% (10\/115) of all confirmed cases, respectively. Most of the suspected cases (63%; 639\/1013) and laboratory-confirmed (57%; 66\/115) cases occurred during the first year of life. Pneumococcal meningitis case fatality rate was 6-fold higher than that of meningococcal meningitis (28% vs 5%). The predominant pneumococcal lineage causing meningitis was sequence type 618 (n = 7), commonly found among serotype 1 isolates. An ST 2174 lineage that included serotypes 19A and 23F was resistant to trimethoprim-sulfamethoxazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There has been a decline in pneumococcal meningitis post\u2013pneumococcal conjugate vaccine introduction in Senegal. However, disease caused by pathogens covered by vaccines in widespread use still persists. There is need for continued effective monitoring of vaccine-preventable meningitis.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciz517","type":"journal-article","created":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T19:09:18Z","timestamp":1560625758000},"page":"S156-S163","source":"Crossref","is-referenced-by-count":18,"title":["Changes in the Molecular Epidemiology of Pediatric Bacterial Meningitis in Senegal After Pneumococcal Conjugate Vaccine Introduction"],"prefix":"10.1093","volume":"69","author":[{"given":"Mouhamadou A","family":"Sonko","sequence":"first","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix S","family":"Dube","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Reference Laboratory, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara"},{"name":"Department of Molecular and Cell Biology, University of Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Bi","family":"Okoi","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Reference Laboratory, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Diop","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliou","family":"Thiongane","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madikay","family":"Senghore","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Reference Laboratory, Medical 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Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baidy","family":"Dieye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idrissa D","family":"Ba","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliou","family":"Diallo","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diop","family":"Boly","sequence":"additional","affiliation":[{"name":"Ministry of Health, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousmane","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa F","family":"Ciss\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National d\u2019Enfants Albert Royer, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M","family":"Mwenda","sequence":"additional","affiliation":[{"name":"World Health Organization, Regional Office for Africa, Immunization, Vaccines, and Development, Brazzaville, Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda A","family":"Kwambana-Adams","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Reference Laboratory, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Antonio","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Reference Laboratory, Medical 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