{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:15Z","timestamp":1787008635179,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key Technology R&D Program of China","award":["2017ZX10104001"],"award-info":[{"award-number":["2017ZX10104001"]}]},{"name":"National Key Technology R&D Program of China","award":["2018ZX10713002"],"award-info":[{"award-number":["2018ZX10713002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An outbreak of an imported Type 1 wild poliovirus from Pakistan occurred in the Xinjiang Uygur Autonomous Region of China in 2011, although the local immunity status of the oral polio vaccine (OPV) was relatively satisfied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Neutralizing antibody titers against the Xinjiang strain and Sabin 1 strain were measured in 237 sera from 3 groups of fully OPV-vaccinated persons and 1 group of infants fully vaccinated with the inactive polio vaccine (IPV). Additionally, 17 sera collected from 1 Xinjiang poliomyelitis case and his 16 contacts were also tested. Genomic sequencing was conducted the Xinjiang strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The antibody titers against the Xinjiang strain in each of 237 sera were significantly lower than those against the Sabin 1 strain. Notably, 40.0% of children in Group 1 were seronegative against the Xinjiang strain, which indicated that they might play an important role in wild poliovirus transmission, although their antibody titers against the Sabin 1 strain varied between 1:8 and 1:512. Meanwhile, serological results of the Xinjiang poliomyelitis case and his contacts also provided evidence that a proportion of OPV-vaccinated children had indeed been involved in the transmission chain of the Xinjiang outbreak. Genomic sequencing indicated that the Xinjiang strain was greatly distinguishable from the Sabin 1 strain in neutralizing antigenic sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The lack of neutralizing antibodies against the Xinjiang strain in persons vaccinated by OPV may be associated with the transmission of Type 1 wild poliovirus in Xinjiang. Using Salk IPV along with OPV might be considered in a wild poliovirus outbreak response, especially in the countries which continued to have persistent wild poliovirus circulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciz549","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T10:20:36Z","timestamp":1561458036000},"page":"1980-1984","source":"Crossref","is-referenced-by-count":5,"title":["Immunogenicity of Oral Polio Vaccine and Salk Inactive Polio Vaccine Against Xinjiang Imported Type 1 Wild Poliovirus"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-3018","authenticated-orcid":false,"given":"Dongmei","family":"Yan","sequence":"first","affiliation":[{"name":"Regional Reference Poliomyelitis Laboratory, World Health Organization Western Pacific Regional Office, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"},{"name":"National Health Commission Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Wang","sequence":"first","affiliation":[{"name":"Regional Reference Poliomyelitis Laboratory, World Health Organization Western Pacific Regional Office, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangli","family":"Zhu","sequence":"first","affiliation":[{"name":"Regional Reference Poliomyelitis Laboratory, World Health Organization Western Pacific Regional Office, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"first","affiliation":[{"name":"Regional Reference Poliomyelitis Laboratory, World Health Organization Western Pacific Regional Office, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"},{"name":"Xinjiang Uyghur Autonomous Region Center for Disease Control and Prevention, Urumqi, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Li","sequence":"first","affiliation":[{"name":"Regional Reference Poliomyelitis Laboratory, World Health Organization Western Pacific Regional Office, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishu","family":"Tang","sequence":"first","affiliation":[{"name":"Xinjiang Uyghur Autonomous Region Center for Disease Control and Prevention, Urumqi, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guan","sequence":"first","affiliation":[{"name":"National Health Commission Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xu","sequence":"first","affiliation":[{"name":"Regional Reference Poliomyelitis Laboratory, World Health Organization Western Pacific Regional Office, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"},{"name":"National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"2020041500553053100_CIT0001","first-page":"55","article-title":"Centers for Disease Control and Prevention. 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