{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:48:12Z","timestamp":1771933692091,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29-AIDS-SHITEI-001"],"award-info":[{"award-number":["H29-AIDS-SHITEI-001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis A virus (HAV) can be sexually transmitted. However, the level of HAV immunity among patients living with human immunodeficiency virus (HIV) in Japan is unknown. Determining the epidemiology of HAV infections among men who have sex with men (MSM) and who are living with HIV is essential for an HAV vaccination program. This study examined HAV immunity in patients living with HIV and applied the decision-tree analysis to explore the factors of immunoglobulin G (IgG)-hepatitis A (HA) antibodies in MSM living with HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the presence of IgG-HA antibodies among patients living with HIV from January to December 2017 in The Hospital of The Institute of Medical Science, The University of Tokyo. We recorded each patient\u2019s age, sex, mode of HIV transmission, year of HIV diagnosis, HAV vaccine status, history of HAV infection, and history of other infectious diseases. A decision-tree algorithm was used to reveal the factors and profiles most relevant to the anti-HAV prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 378 MSM patients living with HIV were examined for IgG-HA antibodies. After excluding 24 patients who had received a HAV vaccine, the data of 354 MSM were analyzed (median age 45 years, interquartile range 39\u201351 years). Of the 354 patients, 60 (16.9%) were positive for IgG-HA antibodies. The HA positivity rate increased with patients\u2019 age, and age (&amp;gt; 63.5 years) was extracted as the most important variable by classification of the decision-tree algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study, conducted just before the HAV outbreak among MSM in Tokyo, showed that age was the most relevant factor in anti-HAV prevalences. An extensive HAV vaccination program for MSM patients living with HIV is urgently needed, particularly for younger people.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciz843","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T11:44:37Z","timestamp":1566560677000},"page":"473-479","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of Hepatitis A Immunity and Decision-tree Analysis Among Men Who Have Sex With Men and Are Living With Human Immunodeficiency Virus in Tokyo"],"prefix":"10.1093","volume":"71","author":[{"given":"Tomohiko","family":"Koibuchi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, The Hospital of The Institute of Medical Science, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Koga","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Acquired Immunodeficiency Syndrome Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizo","family":"Horikomi","sequence":"additional","affiliation":[{"name":"Total Knowledge Inc., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Total Knowledge Inc., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lay Ahyoung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, The Hospital of The Institute of Medical Science, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, The Hospital of The Institute of Medical Science, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeya","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yotsuyanagi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, The Hospital of The Institute of Medical Science, Tokyo, Japan"},{"name":"Division of Infectious Diseases, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 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