{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:32:40Z","timestamp":1790688760981,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"UAB-MS WIHS","award":["U01-AI-103401"],"award-info":[{"award-number":["U01-AI-103401"]}]},{"name":"Atlanta WIHS","award":["U01-AI-103408"],"award-info":[{"award-number":["U01-AI-103408"]}]},{"name":"Bronx WIHS","award":["U01-AI-035004"],"award-info":[{"award-number":["U01-AI-035004"]}]},{"name":"Brooklyn WIHS","award":["U01-AI-031834"],"award-info":[{"award-number":["U01-AI-031834"]}]},{"name":"Chicago WIHS","award":["U01-AI-034993"],"award-info":[{"award-number":["U01-AI-034993"]}]},{"name":"Metropolitan Washington WIHS","award":["U01-AI-034994"],"award-info":[{"award-number":["U01-AI-034994"]}]},{"name":"Miami WIHS","award":["U01-AI-103397"],"award-info":[{"award-number":["U01-AI-103397"]}]},{"name":"Miami WIHS","award":["U01-AI-103390"],"award-info":[{"award-number":["U01-AI-103390"]}]},{"name":"Connie Wofsy Women\u2019s Human Immunodeficiency Virus Study","award":["U01-AI-034989"],"award-info":[{"award-number":["U01-AI-034989"]}]},{"name":"WIHS Data Management and Analysis Center","award":["U01-AI-042590"],"award-info":[{"award-number":["U01-AI-042590"]}]},{"name":"Southern California WIHS","award":["U01-HD-032632"],"award-info":[{"award-number":["U01-HD-032632"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is recommended for human immunodeficiency virus (HIV) management. Although studies have suggested associations between INSTIs and weight gain, women living with HIV (WLHIV) have been underrepresented in research. We evaluated the effect of switching or adding INSTIs among WLHIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women enrolled in the Women\u2019s Interagency HIV Study (WIHS) from 2006\u20132017 who switched to or added an INSTI to ART (SWAD group) were compared to women on non-INSTI ART (STAY group). Body weight, body mass index (BMI), percentage body fat (PBF), and waist, hip, arm, and thigh circumferences were measured 6\u201312 months before and 6\u201318 months after the INSTI switch\/add in SWAD participants, with comparable measurement time points in STAY participants. Linear regression models compared changes over time by SWAD\/STAY group, adjusted for age, race, WIHS site, education, income, smoking status, and baseline ART regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We followed 1118 women (234 SWAD and 884 STAY) for a mean of 2.0 years (+\/\u2212 0.1 standard deviation [SD]; mean age 48.8 years, SD +\/\u2212 8.8); 61% were Black. On average, compared to the STAY group, the SWAD group experienced mean greater increases of 2.1 kg in body weight, 0.8 kg\/m2 in BMI, 1.4% in PBF, and 2.0, 1.9, 0.6, and 1.0 cm in waist, hip, arm, and thigh circumference, respectively (all P values &amp;lt; .05). No differences in magnitudes of these changes were observed by INSTI type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In WLHIV, a switch to INSTI was associated with significant increases in body weight, body circumferences, and fat percentages, compared to non-INSTI ART. The metabolic and other health effects of these changes deserve further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciz853","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T11:36:33Z","timestamp":1566905793000},"page":"593-600","source":"Crossref","is-referenced-by-count":114,"title":["Weight Gain Associated With Integrase Stand Transfer Inhibitor Use in Women"],"prefix":"10.1093","volume":"71","author":[{"given":"Anne Marie","family":"Kerchberger","sequence":"first","affiliation":[{"name":"Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandi N","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D","family":"Angert","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Christina","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ighovwerha","family":"Ofotokun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri D","family":"Weiser","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaora A","family":"Adimora","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey L","family":"French","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Stroger Hospital of Cook County, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Augenbraun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cocohoba","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seble","family":"Kassaye","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Bolivar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Miami Health System, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Govindarajulu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, State University of New York Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Konkle-Parker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious 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