{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:58:19Z","timestamp":1792094299220,"version":"4.4.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Quinolone resistance has been documented in the pediatric population, although their use is limited in children. This study investigated the effect of maternal quinolone use on gram-negative bacterial resistance to quinolones in their offspring.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a population-based, unmatched case-control study during 2010\u20132017. Cases were all children aged 0.5\u201317 years with community acquired, gram-negative quinolone-resistant bacteriuria. Controls were similar children with quinolone-sensitive bacteriuria. Only the first positive urine cultures for each child were included. Data on quinolones dispensed to the mother, any antibiotics dispensed to the children, age, sex, ethnicity, and prior hospitalizations were collected. Children with previous quinolone use were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study population consisted of 40 204 children. Quinolone resistance was detected in 2182 (5.3%) urine cultures. The median age was 5 years, with 93.7% females and 77.6% Jewish. A total of 26 937 (65%) of the children received any antibiotic and 1359 (3.2%) of the mothers received quinolones in the 6 months preceding bacteriuria. Independent risk factors were quinolone dispensed to the mothers (odds ratio [OR], 1.50 [95% confidence interval {CI}, 1.22\u20131.85]), Arab ethnicity (OR, 1.99 [95% CI, 1.81\u20132.19]), and antibiotic dispensed to the child (OR, 1.54 [95% CI, 1.38\u20131.71]). Compared with children aged 12\u201317 years, younger children had 1.33\u20131.43 increased odds for quinolone-resistant bacteriuria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Quinolone prescription to mothers was linked to increased risk of community-acquired, quinolone-resistant bacteria in their offspring, by about 50%. This is another example of the deleterious ecological effects of antibiotic use and should be considered when prescribing antibiotics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz858","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T18:45:20Z","timestamp":1567017920000},"page":"532-538","source":"Crossref","is-referenced-by-count":20,"title":["Quinolone Consumption by Mothers Increases Their Children\u2019s Risk of Acquiring Quinolone-Resistant Bacteriuria"],"prefix":"10.1093","volume":"71","author":[{"given":"Bat-Sheva","family":"Gottesman","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Meir Medical Center, Kfar Saba, Israel"},{"name":"Department of Family Medicine, Sharon-Shomron District, Clalit Health Services, Kfar Saba, Israel"},{"name":"Sackler Medical School, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Low","sequence":"additional","affiliation":[{"name":"Clalit Health Services, Chief Physician\u2019s Office, Tel Aviv, Israel"},{"name":"School of Public Health, University of Haifa, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Almog","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Haifa, Haifa, Israel"},{"name":"Epidemiology Department and Biobank, Rambam Healthcare Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Chowers","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Meir Medical Center, Kfar Saba, Israel"},{"name":"Sackler Medical School, Tel Aviv University, Tel Aviv, 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