{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:30:34Z","timestamp":1781735434386,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others (80% vs 12%; P = .011).<\/jats:p>","DOI":"10.1093\/cid\/ciz904","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T03:21:20Z","timestamp":1568172080000},"page":"1089-1091","source":"Crossref","is-referenced-by-count":31,"title":["Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study"],"prefix":"10.1093","volume":"71","author":[{"given":"Sylvie","family":"Behillil","sequence":"first","affiliation":[{"name":"Unit\u00e9 de G\u00e9n\u00e9tique Mol\u00e9culaire des Virus \u00e0 ARN et Centre National de R\u00e9f\u00e9rence des Virus des Infections Respiratoires (Dont la Grippe), Institut Pasteur, UMR3569 CNRS, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"May","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris-Est Cr\u00e9teil, IMRB, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slim","family":"Fourati","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie, H\u00f4pitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-H\u00f4pitaux de Paris, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Edouard","family":"Luyt","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de La Piti\u00e9 Salp\u00e9tri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Chicheportiche","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de La Piti\u00e9 Salp\u00e9tri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Sonneville","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Bichat Claude Bernard, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Tandjaoui-Lambiotte","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dico-Chirurgicale, H\u00f4pital Avicenne, Assistance Publique-H\u00f4pitaux de Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Roux","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dico Chirurgicale, H\u00f4pital Louis Mourier, Assistance Publique-H\u00f4pitaux de Paris, Colombes, INSERM UMR1137, IAME, Universit\u00e9 Paris Diderot, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Bic\u00e8tre, Assistance Publique-H\u00f4pitaux de Paris, Le Kremlin-Bic\u00e8tre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mayaux","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale et Pneumologie, H\u00f4pital de La Piti\u00e9 Salp\u00e9tri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Maury","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Centre Hospitalier de Versailles, Le Chesnay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Georger","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Centre Hospitalier Intercommunal de Villeneuve Saint-Georges, Villeneuve Saint-Georges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Voiriot","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Enouf","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de G\u00e9n\u00e9tique Mol\u00e9culaire des Virus \u00e0 ARN et Centre National de R\u00e9f\u00e9rence des Virus des Infections Respiratoires (Dont la Grippe), Institut Pasteur, UMR3569 CNRS, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de G\u00e9n\u00e9tique Mol\u00e9culaire des Virus \u00e0 ARN et Centre National de R\u00e9f\u00e9rence des Virus des Infections Respiratoires (Dont la Grippe), Institut Pasteur, UMR3569 CNRS, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand Mekontso","family":"Dessap","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris-Est Cr\u00e9teil, IMRB, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-4320","authenticated-orcid":false,"given":"Nicolas","family":"de Prost","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris-Est Cr\u00e9teil, IMRB, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"2020081419071278100_CIT0001","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1001\/jama.2011.1471","article-title":"Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1)","volume":"306","author":"Noah","year":"2011","journal-title":"JAMA"},{"key":"2020081419071278100_CIT0002","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(14)62449-1","article-title":"Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials","volume":"385","author":"Dobson","year":"2015","journal-title":"Lancet"},{"key":"2020081419071278100_CIT0003","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S2213-2600(14)70041-4","article-title":"Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data","volume":"2","author":"Muthuri","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2020081419071278100_CIT0004","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/jac\/dkq511","article-title":"Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A","volume":"66","author":"Rodr\u00edguez","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"2020081419071278100_CIT0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00134-017-4953-3","article-title":"Early oseltamivir therapy improves the outcome in critically ill patients with influenza: a propensity analysis","volume":"44","author":"Hernu","year":"2018","journal-title":"Intensive Care Med"},{"key":"2020081419071278100_CIT0006","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.antiviral.2012.01.006","article-title":"Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States","volume":"93","author":"Nguyen","year":"2012","journal-title":"Antiviral Res"},{"key":"2020081419071278100_CIT0007","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3201\/eid1702.101724","article-title":"Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States","volume":"17","author":"Graitcer","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"2020081419071278100_CIT0008","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"ARDS Definition Task Force","year":"2012","journal-title":"JAMA"},{"key":"2020081419071278100_CIT0009","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/cid\/cis1220","article-title":"Global assessment of resistance to neuraminidase inhibitors, 2008\u20132011: the Influenza Resistance Information Study (IRIS)","volume":"56","author":"Whitley","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2020081419071278100_CIT0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/irv.12534","article-title":"Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study","volume":"12","author":"Lina","year":"2018","journal-title":"Influenza Other Respir Viruses"},{"issue":"14","key":"2020081419071278100_CIT0011","doi-asserted-by":"crossref","first-page":"pii","DOI":"10.2807\/ese.15.14.19536-en","article-title":"The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009","volume":"15","author":"Harvala","year":"2010","journal-title":"Euro Surveill"},{"key":"2020081419071278100_CIT0012","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/jmv.25013","article-title":"Oseltamivir-resistant influenza A(H1N1)pdm09 virus associated with high case fatality, India 2015","volume":"90","author":"Tandel","year":"2018","journal-title":"J Med Virol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciz904\/30263969\/ciz904.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/4\/1089\/33653858\/ciz904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/4\/1089\/33653858\/ciz904.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T03:38:25Z","timestamp":1664336305000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/71\/4\/1089\/5571955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,9,20]]},"published-print":{"date-parts":[[2020,8,14]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciz904","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8,15]]},"published":{"date-parts":[[2019,9,20]]}}}