{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:50:53Z","timestamp":1792525853746,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["6110-00173B"],"award-info":[{"award-number":["6110-00173B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex, has been suggested to be associated with a range of neurological disorders. In a nationwide, population-based cohort study, we examined the associations between LNB and dementia, Alzheimer\u2019s disease, Parkinson\u2019s disease, motor neuron disease, epilepsy, and Guillain-Barr\u00e9 syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used national registers to identify all Danish residents diagnosed during 1986\u20132016 with LNB (n = 2067), created a gender- and age-matched comparison cohort from the general population (n = 20 670), and calculated risk estimates and hazard ratios.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed no long-term increased risks of dementia, Alzheimer\u2019s disease, Parkinson\u2019s disease, motor neuron diseases, or epilepsy. However, within the first year, 8 (0.4%) of the LNB patients developed epilepsy, compared with 20 (0.1%) of the comparison cohort (difference, 0.3%; 95% confidence interval, .02\u2013.6%). In the LNB group, 11 (0.5%) patients were diagnosed with Guillain-Barr\u00e9 syndrome within the first year after LNB diagnosis, compared with 0 (0.0%) in the comparison cohort. After the first year, the risk of Guillain-Barr\u00e9 was not increased.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LNB patients did not have increased long-term risks of dementia, Alzheimer\u2019s disease, Parkinson\u2019s disease, motor neuron diseases, epilepsy, or Guillain-Barr\u00e9. Although the absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barr\u00e9 syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciz997","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T19:31:01Z","timestamp":1570217461000},"page":"1511-1516","source":"Crossref","is-referenced-by-count":31,"title":["Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study"],"prefix":"10.1093","volume":"71","author":[{"given":"Rasmus","family":"Haahr","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte M","family":"Tetens","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram B","family":"Dessau","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A","family":"Krogfelt","sequence":"additional","affiliation":[{"name":"Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark"},{"name":"Department of Natural Sciences and Environment, Roskilde University, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-814X","authenticated-orcid":false,"given":"Jacob","family":"Bodilsen","sequence":"additional","affiliation":[{"name":"Departments of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Departments of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna S","family":"Andersen","sequence":"additional","affiliation":[{"name":"Clinical Centre for Emerging and Vector-Borne Infections, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens K","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Vejle Hospital, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Roed","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus B","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend","family":"Ellermann-Eriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette M","family":"Bangsborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Herlev University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical 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