{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:34:42Z","timestamp":1784158482244,"version":"3.55.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ExThera Medical Corp"},{"name":"InfectoPharm Arzneimittel & Consilium GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In August 2019, the European Union licensed the first ever haemoperfusion device aimed to reduce pathogens in the blood. The core of the adsorber consists of ultra-high molecular weight polyethylene beads with endpoint-attached heparin. These beads utilize pathogen inherent adhesion mechanisms to reduce pathogen load. So far, it is unknown whether the device has an effect on anti-infective drug concentrations. The aim of this study was to investigate the in vitro adsorption of multiple anti-infective drugs from human plasma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this in vitro study, 18 anti-infective drugs were administered to human donor plasma and pumped through the heparin-coated pathogen adsorber (Seraph\u00ae 100 Microbind\u00aeAffinity Blood Filter; ExThera Medical Corp., Martinez, CA, USA) at a plasma flow rate of 250\u2009mL\/min for 60\u2009min. Pre- and post-adsorber plasma samples were quantified after 5, 15, 30 and 60\u2009min.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found a reduction ratio (RR) in anti-infective plasma levels between \u22121% and 62%. This decrease occurred mainly in the first 5\u2009min of the experiment (RR0\u20135 \u22124 to 62%). Mean plasma clearance rates ranged between \u201311.93\u2009mL\/min (fluconazole) and 4.86\u2009mL\/min (clindamycin). The highest RRs were measured for aminoglycosides (tobramycin 62% and gentamycin 59%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The elimination of anti-infective drugs by the Seraph is neglectable in all but 2 of 18 of the investigated substances. Aminoglycosides may be adsorbed by the device during their first pass.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfaa063","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T20:13:27Z","timestamp":1585340007000},"source":"Crossref","is-referenced-by-count":13,"title":["In vitro elimination of anti-infective drugs by the Seraph\u00ae 100 Microbind\u00ae affinity blood filter"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-7788","authenticated-orcid":false,"given":"Julius J","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Eden","sequence":"first","affiliation":[{"name":"Medical Clinic V, Nephrology | Rheumatology | Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin-Theres","family":"Seffer","sequence":"first","affiliation":[{"name":"Medical Clinic V, Nephrology | Rheumatology | Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Winkler","sequence":"first","affiliation":[{"name":"Medical Clinic V, Nephrology | Rheumatology | Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-9064","authenticated-orcid":false,"given":"Jan T","family":"Kielstein","sequence":"first","affiliation":[{"name":"Medical Clinic V, Nephrology | Rheumatology | Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"2020052112181608000_sfaa063-B1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1186\/s13054-014-0596-8","article-title":"Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study","volume":"18","author":"Zilberberg","year":"2014","journal-title":"Crit Care"},{"key":"2020052112181608000_sfaa063-B2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3389\/fmicb.2014.00551","article-title":"A new strategy to fight antimicrobial resistance: the revival of old antibiotics","volume":"5","author":"Cassir","year":"2014","journal-title":"Front Microbiol"},{"key":"2020052112181608000_sfaa063-B3","doi-asserted-by":"crossref","first-page":"8739","DOI":"10.1021\/es3006496","article-title":"Highly efficient enzyme-functionalized porous zirconia microtubes for bacteria filtration","volume":"46","author":"Kroll","year":"2012","journal-title":"Environ Sci Technol"},{"key":"2020052112181608000_sfaa063-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/nl3047305","article-title":"Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood","volume":"14","author":"Lee","year":"2014","journal-title":"Nano Lett"},{"key":"2020052112181608000_sfaa063-B5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41467-018-02879-9","article-title":"Bacterial capture efficiency in fluid bloodstream improved by bendable nanowires","volume":"9","author":"Liu","year":"2018","journal-title":"Nat Commun"},{"key":"2020052112181608000_sfaa063-B6","doi-asserted-by":"crossref","first-page":"e114242","DOI":"10.1371\/journal.pone.0114242","article-title":"Removal of Carbapenem-Resistant Enterobacteriaceae (CRE) from blood by heparin-functional hemoperfusion media","volume":"9","author":"McCrea","year":"2014","journal-title":"PLoS One"},{"key":"2020052112181608000_sfaa063-B7","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1128\/IAI.01327-07","article-title":"The hek outer membrane protein of Escherichia coli strain RS218 binds to proteoglycan and utilizes a single extracellular loop for adherence, invasion, and autoaggregation","volume":"76","author":"Fagan","year":"2008","journal-title":"Infect Immun"},{"key":"2020052112181608000_sfaa063-B8","doi-asserted-by":"crossref","first-page":"i332","DOI":"10.1093\/ndt\/gfy104.SaO040","article-title":"Sao040treatment of bacteremia during dialysis using a biomimetic sorbent hemoperfusion device - 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