{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T06:46:53Z","timestamp":1749278813917,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Understanding and applying pathophysiological concepts to patient care is an important skill for physicians in the clinical setting. Here, we present a case that demonstrates how the application of common physiological concepts relating to the widely accepted hyponatremia algorithm led to an accurate diagnosis of hyponatremia. This case documents iso-osmolar hyponatremia caused by orally administered polyethylene glycol absorption in the gastrointestinal tract. Herein, we discuss the workup and differential diagnosis for iso-osmolar hyponatremia in juxtaposition with the pathophysiological mechanisms unique to this case. We discuss these pathophysiological mechanisms based on the patients\u2019 laboratory data and responses to therapeutic interventions.<\/jats:p>","DOI":"10.1093\/ckj\/sfaa087","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T11:09:48Z","timestamp":1588072188000},"page":"715-719","source":"Crossref","is-referenced-by-count":3,"title":["Iso-osmolar hyponatremia from polyethylene glycol"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-6786","authenticated-orcid":false,"given":"Bryan M","family":"Tucker","sequence":"first","affiliation":[{"name":"Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L","family":"Pirkle","sequence":"additional","affiliation":[{"name":"Section on Nephrology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, 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