{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:20:22Z","timestamp":1762543222895,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recent data have shown that severe acute respiratory syndrome coronavirus 2 can infect renal proximal tubular cells via Angiotensin Converting Enzyme 2 (ACE2) . Our objective was to determine whether Fanconi syndrome is a frequent clinical feature in coronavirus disease 2019 (COVID-19) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort of 42 laboratory-confirmed COVID-19 patients without history of kidney disease hospitalized in University Hospital of Nancy was investigated. Patients were admitted to the intensive care unit (ICU) (n = 28) or the Medical department (n = 14) and were screened at least once for four markers of proximal tubulopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean (standard deviation) follow-up was 19.7 (\u00b112.2) days. Of the patients, 75% (30\/40) showed at least two proximal tubule abnormalities (incomplete Fanconi syndrome). The main disorders were proteinuria (88%, n = 35), renal phosphate leak defined by renal phosphate threshold\/glomerular filtration rate (TmPi\/GFR) &amp;lt;0.77 (55%, n\u2009=\u200922), hyperuricosuria (43%, n\u2009=\u200917) and normoglycaemic glycosuria (30%, n\u2009=\u200912). At the time of the first renal evaluation, ICU patients presented more frequent (96 versus 62%, P\u2009=\u20090.0095) and more severe (844\u2009\u00b1\u2009343 versus 350\u2009\u00b1\u2009221\u00a0mg\/g, P\u2009=\u20090.0001) proteinuria, and a trend for an increased number of proximal tubule abnormalities (P = 0.038). During follow-up, they presented a lower nadir of serum phosphate [median (interquartile range) 0.68 (0.43\u20130.76) versus 0.77 (0.66\u20131.07)\u00a0mmol\/L, P\u2009=\u20090.044] and Acute kidney Injury (AKI) during the hospitalization (P\u2009=\u20090.045). Fanconi syndrome preceded severe AKI KDIGO Stages 2 and 3 in 88% (7\/8) of patients. Proximal tubular abnormalities (such as proteinuria, TmPi\/GFR and glycosuria in five, two and two patients, respectively) were not detected anymore in recovering patients before hospital discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Incomplete Fanconi syndrome is highly frequent in COVID-19 patients and precedes AKI or disappears during the recovery phase.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfaa109","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T13:23:33Z","timestamp":1589289813000},"source":"Crossref","is-referenced-by-count":19,"title":["Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-6849","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Kormann","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Jacquot","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Alla","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Corbel","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Koszutski","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Voirin","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"},{"name":"Department of Infectious and Tropical Diseases, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Garcia Parrilla","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybille","family":"Bevilacqua","sequence":"first","affiliation":[{"name":"Department of Infectious and Tropical Diseases, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Schvoerer","sequence":"first","affiliation":[{"name":"Department of Microbiology, Division of Virology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Gueant","sequence":"first","affiliation":[{"name":"INSERM UMRS 1256 NGERE (Nutrition Genetics Environmental Risk Exposure), University of Lorraine, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Far\u00e8s","family":"Namour","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"},{"name":"INSERM UMRS 1256 NGERE (Nutrition Genetics Environmental Risk Exposure), University of Lorraine, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"},{"name":"INSERM U1116, University of Lorraine, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Frimat","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Lorraine, CHRU-Nancy, Vandoeuvre, France"},{"name":"INSERM CIC-EC CIE6, University of Lorraine, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abderrahim","family":"Oussalah","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University of 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