{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:29:54Z","timestamp":1784698194909,"version":"3.55.0"},"reference-count":128,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For decades, researchers have been trying to decipher the complex pathophysiology of autosomal dominant polycystic kidney disease (ADPKD). So far these efforts have led to clinical trials with different candidate treatments, with tolvaptan being the only molecule that has gained approval for this indication. As end-stage kidney disease due to ADPKD has a substantial impact on health expenditures worldwide, it is likely that new drugs targeting kidney function will be developed. On the other hand, recent clinical observations and experimental data, including PKD knockout models in various cell types, have revealed unexpected involvement of many other organs and cell systems of variable severity. These novel non-cystic features, some of which, such as lymphopenia and an increased risk to develop infections, should be validated or further explored and might open new avenues for better risk stratification and a more tailored approach. New insights into the aberrant pathways involved with abnormal expression of PKD gene products polycystin-1 and -2 could, for instance, lead to a more directed approach towards early-onset endothelial dysfunction and subsequent cardiovascular disease. Furthermore, a better understanding of cellular pathways in PKD that can explain the propensity to develop certain types of cancer can guide post-transplant immunosuppressive and prophylactic strategies. In the following review article we will systematically discuss recently discovered non-cystic features of PKD and not well-established characteristics. Overall, this knowledge could enable us to improve the outcome of PKD patients apart from ongoing efforts to slow down cyst growth and attenuate kidney function decline.<\/jats:p>","DOI":"10.1093\/ckj\/sfaa138","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T03:18:12Z","timestamp":1592623092000},"page":"746-755","source":"Crossref","is-referenced-by-count":6,"title":["Novel non-cystic features of polycystic kidney disease: having new eyes or seeking new landscapes"],"prefix":"10.1093","volume":"14","author":[{"given":"Steven","family":"Van Laecke","sequence":"first","affiliation":[{"name":"Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Van Biesen","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"2021032313081297600_sfaa138-B1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","article-title":"Autosomal dominant polycystic kidney disease","volume":"393","author":"Cornec-Le Gall","year":"2019","journal-title":"Lancet"},{"key":"2021032313081297600_sfaa138-B2","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.transproceed.2014.07.044","article-title":"Complicated diverticulitis in kidney transplanted patients: analysis of 717 cases","volume":"46","author":"Scotti","year":"2014","journal-title":"Transplant Proc"},{"key":"2021032313081297600_sfaa138-B3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0272-6386(87)80036-7","article-title":"Renal infections in autosomal dominant polycystic kidney disease","volume":"10","author":"Sklar","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"2021032313081297600_sfaa138-B4","first-page":"2054358119839080","article-title":"Infectious disease risk in dialysis patients: a transdisciplinary approach","volume":"29","author":"Lamarche","year":"2019","journal-title":"Can J Kidney Health Dis"},{"key":"2021032313081297600_sfaa138-B5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.euf.2016.08.006","article-title":"Urinary tract infections in immunocompromised patients with diabetes, chronic kidney disease, and kidney transplant","volume":"2","author":"Tandogdu","year":"2016","journal-title":"Eur Urol Focus"},{"key":"2021032313081297600_sfaa138-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2369-14-1","article-title":"Chronic asymptomatic pyuria precedes overt urinary tract infection and deterioration of renal function in autosomal dominant polycystic kidney disease","volume":"14","author":"Hwang","year":"2013","journal-title":"BMC Nephrol"},{"key":"2021032313081297600_sfaa138-B7","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/ndt\/11.7.1271","article-title":"Complications of autosomal dominant polycystic kidney disease in 50 haemodialysed patients. 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