{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:55:45Z","timestamp":1787774145046,"version":"build-2784847793"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK106618"],"award-info":[{"award-number":["DK106618"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,2]]},"abstract":"<jats:title>\u2002<\/jats:title>\n               <jats:p>Primary aldosteronism is the most common cause of secondary hypertension; however, the dynamic regulation of aldosterone by potassium is less well studied and current diagnostic recommendations are imprecise. We describe a young man who presented with resistant hypertension and severe hypokalemia. The workup initially revealed undetectable aldosterone despite acute potassium repletion. Chronic potassium supplementation eventually uncovered hyperaldosteronism. In situ genetic studies revealed a gain-of-function KCNJ5 mutation within an aldosterone-producing adenoma that was clinically responsive to changes in extracellular potassium. We highlight a unique presentation of Conn\u2019s syndrome and discuss the implications for the molecular mechanisms of potassium regulation of aldosterone.<\/jats:p>","DOI":"10.1093\/ckj\/sfaa150","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:30:18Z","timestamp":1596195018000},"page":"1269-1271","source":"Crossref","is-referenced-by-count":4,"title":["Masking by hypokalemia\u2014primary aldosteronism with undetectable aldosterone"],"prefix":"10.1093","volume":"14","author":[{"given":"Rebecca A","family":"Boyle","sequence":"first","affiliation":[{"name":"Stanford Hypertension Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"},{"name":"Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"},{"name":"Stanford HealthCare, Stanford Hospital, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Stanford Hypertension Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"},{"name":"Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"2021060310401925700_sfaa150-B1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol 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