{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:50:23Z","timestamp":1790747423655,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Information regarding coronavirus disease 2019 (COVID-19) in haemodialysis (HD) patients is limited and early studies suggest a poor outcome. We aimed to identify clinical and biological markers associated with severe forms of COVID-19 in HD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective, observational and multicentric study. Sixty-two consecutive adult HD patients with confirmed COVID-19 from four dialysis facilities in Paris, France, from 19 March to 19 May 2020 were included.<\/jats:p>\n                  <jats:p>Blood tests were performed before diagnosis and at Days 7 and 14 after diagnosis. Severe forms of COVID-19 were defined as requiring oxygen therapy, admission in an intensive care unit or death. Cox regression models were used to compute adjusted hazard ratios (aHRs). Kaplan\u2013Meier curves and log-rank tests were used for survival analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-eight patients (45%) displayed severe forms of COVID-19. Compared with non-severe forms, these patients had more fever (93% versus 56%, P\u2009&amp;lt;\u20090.01), cough (71% versus 38%, P\u2009=\u20090.02) and dyspnoea (43% versus 6%, P\u2009&amp;lt;\u20090.01) at diagnosis. At Day 7 post-diagnosis, neutrophil counts, neutrophil:lymphocyte (N:L) ratio, C-reactive protein, ferritin, fibrinogen and lactate dehydrogenase levels were significantly higher in severe COVID-19 patients. Multivariate analysis revealed an N:L ratio &amp;gt;3.7 was the major marker associated with severe forms, with an aHR of 4.28 (95% confidence interval 1.52\u201312.0; P\u2009=\u20090.006). After a median follow-up time of 48\u2009days (range 27\u201361), six patients with severe forms died (10%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>HD patients are at increased risk of severe forms of COVID-19. An elevated N:L ratio at Day 7 was highly associated with the severe forms. Assessing the N:L ratio could inform clinicians for early treatment decisions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfaa194","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T05:40:10Z","timestamp":1598679610000},"page":"124-131","source":"Crossref","is-referenced-by-count":18,"title":["Neutrophil:lymphocyte ratio predicts short-term outcome\u00a0of COVID-19 in haemodialysis patients"],"prefix":"10.1093","volume":"14","author":[{"given":"Prisca","family":"Mutinelli-Szymanski","sequence":"first","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Hude","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Merle","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Lombardi","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Seris","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhi","family":"Abtahi","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latifa","family":"Azeroual","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Bourgain","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gael","family":"Ensergueix","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Katerinis","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kolko","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Kolta","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Maheas","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Mehrbanian","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Morel","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Ossman","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne de","family":"Pr\u00e9neuf","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Roux","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Saltiel","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Vend\u00e9","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Viron","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Laplanche","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie M\u00e9dicale, Groupe Hospitalier Saint-Joseph, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Le Monnier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie, Groupe Hospitalier Saint-Joseph, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ridel","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ure\u00f1a-Torres","sequence":"additional","affiliation":[{"name":"AURA Saint-Ouen, Dialyse, Saint-Ouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Touzot","sequence":"additional","affiliation":[{"name":"AURA Paris Plaisance, Dialyse et aph\u00e9r\u00e8se th\u00e9rapeutique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"2021020321174071700_sfaa194-B1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s00134-020-06028-z","article-title":"Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China","volume":"46","author":"Ruan","year":"2020","journal-title":"Intensive Care Med"},{"key":"2021020321174071700_sfaa194-B2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jamacardio.2020.0950","article-title":"Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China","volume":"5","author":"Shi","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2021020321174071700_sfaa194-B3","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"2021020321174071700_sfaa194-B4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000170143","article-title":"T cell function in chronic renal failure and dialysis","volume":"12","author":"Kelly","year":"1994","journal-title":"Blood Purif"},{"key":"2021020321174071700_sfaa194-B5","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2215\/CJN.00950208","article-title":"Aspects of immune dysfunction in end-stage renal disease","volume":"3","author":"Kato","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021020321174071700_sfaa194-B6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.kint.2020.04.031","article-title":"COVID-19: clinical course and outcomes of 36 hemodialysis patients in Spain","volume":"98","author":"Goicoechea","year":"2020","journal-title":"Kidney Int"},{"key":"2021020321174071700_sfaa194-B7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.kint.2020.04.030","article-title":"A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection","volume":"98","author":"Alberici","year":"2020","journal-title":"Kidney Int"},{"key":"2021020321174071700_sfaa194-B8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/j.ajkd.2020.03.009","article-title":"COVID-19 in hemodialysis patients: a report of 5 cases","volume":"76","author":"Wang","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"2021020321174071700_sfaa194-B9","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1073\/pnas.2005615117","article-title":"Effective treatment of severe COVID-19 patients with tocilizumab","volume":"117","author":"Xu","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021020321174071700_sfaa194-B10","author":"Ma","year":"2020"},{"key":"2021020321174071700_sfaa194-B11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.kint.2020.04.017","article-title":"Could ferritin help the screening for COVID-19 in hemodialysis patients?","volume":"98","author":"Bataille","year":"2020","journal-title":"Kidney Int"},{"key":"2021020321174071700_sfaa194-B12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/ndt\/gfaa069","article-title":"Recommendations for the prevention, mitigation and containment of the emerging SARS-CoV-2 (COVID-19) pandemic in haemodialysis centres","volume":"35","author":"Basile","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2021020321174071700_sfaa194-B13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"2021020321174071700_sfaa194-B14","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunologic features in severe and moderate coronavirus disease 2019","volume":"130","author":"Chen","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"2021020321174071700_sfaa194-B15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"2021020321174071700_sfaa194-B16","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"key":"2021020321174071700_sfaa194-B17","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1172\/JCI137647","article-title":"SARS-CoV-2: a storm is raging","volume":"130","author":"Pedersen","year":"2020","journal-title":"J Clin Invest"},{"key":"2021020321174071700_sfaa194-B18","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of immune response in patients with COVID-19 in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2021020321174071700_sfaa194-B19","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2020-217706","article-title":"Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series","author":"Aouba","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2021020321174071700_sfaa194-B20","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/HYPERTENSIONAHA.120.15082","article-title":"Renin\u2013angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers","volume":"75","author":"Danser","year":"2020","journal-title":"Hypertension"},{"key":"2021020321174071700_sfaa194-B21","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa2006923","article-title":"Renin\u2013angiotensin\u2013aldosterone system blockers and the risk of COVID-19","volume":"382","author":"Mancia","year":"2020","journal-title":"N Engl J Med"},{"key":"2021020321174071700_sfaa194-B22","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa2008975","article-title":"Renin\u2013angiotensin\u2013aldosterone system inhibitors and risk of COVID-19","volume":"382","author":"Reynolds","year":"2020","journal-title":"N\u00a0Engl J Med"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/1\/124\/36184838\/sfaa194.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/1\/124\/36184838\/sfaa194.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T10:11:02Z","timestamp":1612779062000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/14\/1\/124\/5998261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,11,21]]},"published-print":{"date-parts":[[2021,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfaa194","relation":{},"ISSN":["2048-8513"],"issn-type":[{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,11,21]]}}}