{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:02:05Z","timestamp":1783652525650,"version":"3.55.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recurrence of primary focal segmental glomerulosclerosis (FSGS) occurs in up to 50% of patients after kidney transplantation and is associated with poor allograft outcome. Novel therapeutic concepts directly target podocyte function via B7-1 with inconsistent response. We present the case of a 19-year-old patient with recurrent primary FSGS early after living donor kidney transplantation. Plasmapheresis and rituximab did not induce remission. Repetitive abatacept administration was able to achieve partial remission. Maintenance immunosuppression was subsequently switched to a belatacept-based calcineurin inhibitor-free immunosuppression, resulting in sustained complete remission with excellent allograft function throughout a follow-up of &amp;gt;56\u2009months.<\/jats:p>","DOI":"10.1093\/ckj\/sfaa267","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T05:10:14Z","timestamp":1607490614000},"page":"1691-1693","source":"Crossref","is-referenced-by-count":10,"title":["Successful long-term management of recurrent focal segmental glomerulosclerosis after kidney transplantation with costimulation blockade"],"prefix":"10.1093","volume":"14","author":[{"given":"Thomas","family":"M\u00fchlbacher","sequence":"first","affiliation":[{"name":"Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD e. V.), Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[{"name":"Department of Nephropathology, Institute of Pathology, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Mahling","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD e. V.), Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Nadalin","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Heyne","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD e. V.), Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-980X","authenticated-orcid":false,"given":"Martina","family":"Guthoff","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD e. V.), Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"2021052818102907000_sfaa267-B1","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1111\/j.1600-6143.2006.01502.x","article-title":"Recurrent glomerulonephritis after kidney transplantation","volume":"6","author":"Choy","year":"2006","journal-title":"Am J Transplant"},{"key":"2021052818102907000_sfaa267-B2","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa1304572","article-title":"Abatacept in B7-1-positive proteinuric kidney disease","volume":"369","author":"Yu","year":"2013","journal-title":"N Engl J Med"},{"key":"2021052818102907000_sfaa267-B3","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1681\/ASN.2015091002","article-title":"B7-1 blockade does not improve post-transplant nephrotic syndrome caused by recurrent FSGS","volume":"27","author":"Delville","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2021052818102907000_sfaa267-B4","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI20402","article-title":"Induction of B7-1 in podocytes is associated with nephrotic syndrome","volume":"113","author":"Reiser","year":"2004","journal-title":"J Clin Invest"},{"key":"2021052818102907000_sfaa267-B5","first-page":"2017","article-title":"Focal segmental glomerulosclerosis recurrence in renal transplant recipients treated with belatacept [abstract]","volume":"17","author":"Kitchens AF","year":"2017","journal-title":"Am J Transplant"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfaa267\/37371383\/sfaa267.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/6\/1691\/38375550\/sfaa267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/6\/1691\/38375550\/sfaa267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T19:41:56Z","timestamp":1622230916000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/14\/6\/1691\/6045984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12,23]]},"published-print":{"date-parts":[[2021,5,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfaa267","relation":{},"ISSN":["2048-8513"],"issn-type":[{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6,1]]},"published":{"date-parts":[[2020,12,23]]}}}