{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:16:36Z","timestamp":1777486596666,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Insulin\u2013glucose therapy in hyperkalaemia treatment has a narrow therapeutic index for a safe and efficient use. We assess the variability of the effective delivered insulin under conditions used in the setting of hyperkalaemia treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A range of simulated insulin infusions was studied using different containers (bag or syringes) according to the different hyperkalaemia treatment procedures of our institution. Insulin concentration was assayed using a chromatographic method on an automatic high-performance liquid chromatography. We calculated the effective delivered insulin and compared the time average of percentage delivered insulin (TAdi) between all the procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The TAdi was significantly decreased to 63.3% of the expected insulin delivery in the polyurethane (PE) bag compared with allover container. The procedure duration and the insulin concentration influenced the variability of the insulin delivery in the PE and glass bag. The polyvinyl chloride bag had the highest TAdi at 93.8%, without significant variation during the time. TAdi reaches \u223c90% of the expected insulin with all the syringe procedure without variation according to the solute used to dilute insulin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Clinically significant variations in intravenous insulin delivery occur in the setting of hyperkalaemia treatment according to the container. The use of propylene syringe limits the insulin delivery variation. In the future, clinical studies on hyperkalaemia treatment by insulin\u2013glucose therapy should detail the procedure precisely.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfab033","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T20:12:43Z","timestamp":1611951163000},"page":"2255-2260","source":"Crossref","is-referenced-by-count":7,"title":["Impact of insulin adsorption in various containers during hyperkalaemia treatment"],"prefix":"10.1093","volume":"14","author":[{"given":"Thomas","family":"Robert","sequence":"first","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation, H\u00f4pital de la Conception, CHU de Marseille, Marseille, France"},{"name":"MMG, Bioinformatics & Genetics, UMRS_1251, Aix-Marseille Universit\u00e9, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Vanelle","sequence":"additional","affiliation":[{"name":"Service central de la qualit\u00e9 et de l'information pharmaceutiques (SCQIP), Pharmacy Department, Assistance Publique\u2014H\u00f4pitaux de Marseille (AP-HM), Marseille, France"},{"name":"Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Equipe de Pharmaco-Chimie Radicalaire, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Brunet","sequence":"additional","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation, H\u00f4pital de la Conception, CHU de Marseille, Marseille, France"},{"name":"Aix-Marseille Univ, INSERM, INRAe, C2VN, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Martin","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, H\u00f4pital de la Conception, Pharmacy Department, Assistance Publique\u2014H\u00f4pitaux de Marseille (AP-HM), Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Burtey","sequence":"additional","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation, H\u00f4pital de la Conception, CHU de Marseille, Marseille, France"},{"name":"Aix-Marseille Univ, INSERM, INRAe, C2VN, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Curti","sequence":"additional","affiliation":[{"name":"Service central de la qualit\u00e9 et de l'information pharmaceutiques (SCQIP), Pharmacy Department, Assistance Publique\u2014H\u00f4pitaux de Marseille (AP-HM), Marseille, France"},{"name":"Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Equipe de Pharmaco-Chimie Radicalaire, Marseille, 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administration sets","volume":"10","author":"Tol","year":"1988","journal-title":"Pharm Weekbl Sci"},{"key":"2021093019470321700_sfab033-B4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/dia.2006.8.598","article-title":"\u201cWaste not, want not\u201d: determining the optimal priming volume for intravenous insulin infusions","volume":"8","author":"Goldberg","year":"2006","journal-title":"Diabetes Technol Ther"},{"key":"2021093019470321700_sfab033-B5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jpba.2005.10.016","article-title":"Quantitative determination of insulin entrapment efficiency in triblock copolymeric nanoparticles by high-performance liquid chromatography","volume":"41","author":"Xu","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"2021093019470321700_sfab033-B6","doi-asserted-by":"crossref","first-page":"e0201623","DOI":"10.1371\/journal.pone.0201623","article-title":"In vitro assessment of the influence of intravenous 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