{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:32:09Z","timestamp":1740166329052,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cinacalcet and, more recently, etelcalcetide revolutionized the treatment of chronic kidney disease\u2013mineral and bone disorder (CKD\u2013MBD). Kidney transplant (KT) usually improves CKD\u2013MBD. However, a significant proportion of KT recipients have high serum calcium levels, not requiring any treatment. We report two patients previously treated with etelcalcetide who developed severe (&amp;gt;3.3\u2009mmol\/L) hypercalcaemia in the early post-KT course, requiring parathyroidectomy. Pathological studies showed parathyroid adenomas and hyperplasia. One patient had a graft biopsy showing numerous intratubular calcium phosphate crystals. These observations should prompt pharmacovigilance studies and careful follow-up of KT recipients previously treated with etelcalcetide.<\/jats:p>","DOI":"10.1093\/ckj\/sfab063","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T20:13:34Z","timestamp":1615839214000},"page":"1977-1979","source":"Crossref","is-referenced-by-count":4,"title":["Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-975X","authenticated-orcid":false,"given":"Guillaume","family":"Dachy","sequence":"first","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Pochet","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-881X","authenticated-orcid":false,"given":"Laura","family":"Labriola","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Buemi","sequence":"additional","affiliation":[{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"},{"name":"Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentine","family":"Gillion","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-7812","authenticated-orcid":false,"given":"Michel","family":"Jadoul","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Kanaan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Devresse","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"2021073010133680000_sfab063-B1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/sdi.12734","article-title":"Treatment of secondary hyperparathyroidism: how do cinacalcet and etelcalcetide differ?","volume":"31","author":"Eidman","year":"2018","journal-title":"Semin Dial"},{"key":"2021073010133680000_sfab063-B2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/jama.2016.19456","article-title":"Effect of etelcalcetide vs placebo on serum parathyroid hormone in patients receiving hemodialysis with secondary hyperparathyroidism: two randomized clinical trials","volume":"317","author":"Block","year":"2017","journal-title":"JAMA"},{"key":"2021073010133680000_sfab063-B3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3390\/jcm8071066","article-title":"Etelcalcetide in patients on hemodialysis with severe secondary hyperparathyroidism. Multicenter study in \u201creal life\u201d","volume":"8","author":"Russo","year":"2019","journal-title":"J Clin Med"},{"key":"2021073010133680000_sfab063-B4","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/ndt\/gfm044","article-title":"Parathyroidectomy after successful kidney transplantation: a single centre study","volume":"22","author":"Evenepoel","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"2021073010133680000_sfab063-B5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-030-43769-5_4","volume-title":"Parathyroid Glands in Chronic Kidney Disease","author":"Bover","year":"2020"},{"key":"2021073010133680000_sfab063-B6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1399-0012.2011.01524.x","article-title":"Mineral metabolism in renal transplant recipients discontinuing cinacalcet at the time of transplantation: a prospective observational study","volume":"26","author":"Evenepoel","year":"2012","journal-title":"Clin Transplant"},{"key":"2021073010133680000_sfab063-B7","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1681\/ASN.2015060622","article-title":"A randomized study comparing parathyroidectomy with cinacalcet for treating hypercalcemia in kidney allograft recipients with hyperparathyroidism","volume":"27","author":"Cruzado","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2021073010133680000_sfab063-B8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13104-017-2477-0","article-title":"Successful treatment of early allograft dysfunction with cinacalcet in a patient with nephrocalcinosis caused by severe hyperparathyroidism: a case report","volume":"10","author":"Cheunsuchon","year":"2017","journal-title":"BMC Res Notes"},{"key":"2021073010133680000_sfab063-B9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12882-019-1355-5","article-title":"Predictors of cinacalcet discontinuation and reinitiation in hemodialysis patients: results from 7 European countries","volume":"20","author":"Fuller","year":"2019","journal-title":"BMC Nephrol"},{"key":"2021073010133680000_sfab063-B10","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1124\/dmd.115.068007","article-title":"Nonclinical pharmacokinetics, disposition, and drug-drug interaction potential of a novel d-amino acid peptide agonist of the calcium-sensing receptor AMG 416 (etelcalcetide)","volume":"44","author":"Subramanian","year":"2016","journal-title":"Drug Metab Dispos"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfab063\/37377068\/sfab063.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/8\/1977\/39449786\/sfab063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/8\/1977\/39449786\/sfab063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T10:28:30Z","timestamp":1627640910000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/14\/8\/1977\/6174687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,3,17]]},"published-print":{"date-parts":[[2021,7,29]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfab063","relation":{},"ISSN":["2048-8513"],"issn-type":[{"type":"electronic","value":"2048-8513"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,3,17]]}}}