{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:54:39Z","timestamp":1792313679323,"version":"4.4.0"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A brief comprehensive overview is provided of the elements constituting the burden of kidney disease [chronic kidney disease (CKD) and acute kidney injury]. This publication can be used for advocacy, emphasizing the importance and urgency of reducing this heavy and rapidly growing burden. Kidney diseases contribute to significant physical limitations, loss of quality of life, emotional and cognitive disorders, social isolation and premature death. CKD affects close to 100 million Europeans, with 300 million being at risk, and is projected to become the fifth cause of worldwide death by 2040. Kidney disease also imposes financial burdens, given the costs of accessing healthcare and inability to work. The extrapolated annual cost of all CKD is at least as high as that for cancer or diabetes. In addition, dialysis treatment of kidney diseases imposes environmental burdens by necessitating high energy and water consumption and producing plastic waste. Acute kidney injury is associated with further increases in global morbidity, mortality and economic burden. Yet investment in research for treatment of kidney disease lags behind that of other diseases. This publication is a call for European investment in research for kidney health. The innovations generated should mirror the successful European Union actions against cancer over the last 30\u2009years. It is also a plea to nephrology professionals, patients and their families, caregivers and kidney health advocacy organizations to draw, during the Decade of the Kidney (2020\u201330), the attention of authorities to realize changes in understanding, research and treatment of kidney disease.<\/jats:p>","DOI":"10.1093\/ckj\/sfab070","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T20:54:53Z","timestamp":1618433693000},"page":"1719-1730","source":"Crossref","is-referenced-by-count":149,"title":["Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-1636","authenticated-orcid":false,"given":"Raymond","family":"Vanholder","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium"},{"name":"European Kidney Health Alliance, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Annemans","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Ghent University, Ghent, Belgium"},{"name":"Department of Public Health, Interuniversity Center for Health Economics Research (I-CHER), Free University of Brussels, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminu K","family":"Bello","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Bikbov","sequence":"additional","affiliation":[{"name":"Istituto di Richerche Farmcologiche Mario Negri RICCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gallego","sequence":"additional","affiliation":[{"name":"European Kidney Patient Federation (EKPF), Dublin, Ireland"},{"name":"Spanish Kidney Patient Federation (ALCER), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T","family":"Gansevoort","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Lameire","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics,\u2002Nephrology Section, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A","family":"Luyckx","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa"},{"name":"Renal Division, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edita","family":"Noruisiene","sequence":"additional","affiliation":[{"name":"European Dialysis and Transplant Nurses Association\u2013European Renal Care Association (EDTNA\/ERCA), Nidwalden, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Oostrom","sequence":"additional","affiliation":[{"name":"Dutch Kidney Foundation, Bussum, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Nephrology Section, W\u00fcrzburg University, W\u00fcrzburg University Hospital, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fokko","family":"Wieringa","sequence":"additional","affiliation":[{"name":"IMEC Eindhoven, Eindhoven, the Netherlands"},{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"2021070806492578700_sfab070-B1"},{"key":"2021070806492578700_sfab070-B2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41581-018-0052-0","article-title":"Global epidemiology and outcomes of acute kidney injury","volume":"14","author":"Hoste","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"Lameire","year":"2013","journal-title":"Lancet"},{"key":"2021070806492578700_sfab070-B4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ki.2012.208","article-title":"Acute kidney injury and chronic kidney disease: an integrated clinical syndrome","volume":"82","author":"Chawla","year":"2012","journal-title":"Kidney Int"},{"key":"2021070806492578700_sfab070-B5"},{"key":"2021070806492578700_sfab070-B6"},{"key":"2021070806492578700_sfab070-B7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/ndt\/gfh813","article-title":"Chronic kidney disease as cause of cardiovascular morbidity and mortality","volume":"20","author":"Vanholder","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S2213-8587(15)00040-6","article-title":"Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data","volume":"3","author":"Matsushita","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2021070806492578700_sfab070-B9","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.2215\/CJN.00290109","article-title":"Pill burden, adherence, hyperphosphatemia, and quality of life in maintenance dialysis patients","volume":"4","author":"Chiu","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/ckj\/sfu091","article-title":"Medication burden in CKD-5D: impact of dialysis modality and setting","volume":"7","author":"Parker","year":"2014","journal-title":"Clin Kidney J"},{"key":"2021070806492578700_sfab070-B11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00467-018-3920-8","article-title":"A plea for more uremic toxin research in children with chronic kidney disease","volume":"33","author":"Snauwaert","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"2021070806492578700_sfab070-B12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ckj\/sfz001","article-title":"Sarcopenia in CKD: a roadmap from basic pathogenetic mechanisms to clinical trials","volume":"12","author":"Ortiz","year":"2019","journal-title":"Clin Kidney J"},{"key":"2021070806492578700_sfab070-B13","doi-asserted-by":"crossref","first-page":"e0175161","DOI":"10.1371\/journal.pone.0175161","article-title":"Employment 12 months after kidney transplantation: an in-depth bio-psycho-social analysis of the Swiss Transplant Cohort","volume":"12","author":"Danuser","year":"2017","journal-title":"PLoS One"},{"key":"2021070806492578700_sfab070-B14","first-page":"11","article-title":"L. Employment in patients with renal replacement therapy","volume":"3","author":"Dukic","year":"2019","journal-title":"SEEMed J"},{"key":"2021070806492578700_sfab070-B15","first-page":"439","article-title":"Employment in the patient with chronic kidney disease related to renal replacement therapy","volume":"32","author":"Julian","year":"2012","journal-title":"Nefrologia"},{"key":"2021070806492578700_sfab070-B16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"2021070806492578700_sfab070-B17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrneph.2017.52","article-title":"The systemic nature of CKD","volume":"13","author":"Zoccali","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B18"},{"key":"2021070806492578700_sfab070-B19","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1093\/ndt\/gfz174","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"34","author":"Jager","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.kisu.2017.08.001","article-title":"Global Kidney Health Atlas (GKHA): design and methods","volume":"7","author":"Bello","year":"2017","journal-title":"Kidney Int Suppl (2011)"},{"key":"2021070806492578700_sfab070-B21"},{"key":"2021070806492578700_sfab070-B22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/j.ackd.2010.03.002","article-title":"Awareness of chronic kidney disease among patients and providers","volume":"17","author":"Plantinga","year":"2010","journal-title":"Adv Chronic Kidney Dis"},{"key":"2021070806492578700_sfab070-B23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.amjmed.2011.11.026","article-title":"Awareness of kidney disease and relationship to end-stage renal disease and mortality","volume":"125","author":"Whaley-Connell","year":"2012","journal-title":"Am J Med"},{"key":"2021070806492578700_sfab070-B24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jhm.2395","article-title":"Hospitalized patients frequently unaware of their chronic kidney disease","volume":"10","author":"Saunders","year":"2015","journal-title":"J Hosp Med"},{"key":"2021070806492578700_sfab070-B25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0272-6386(03)00916-8","article-title":"A population-based study of the incidence and outcomes of diagnosed chronic kidney disease","volume":"42","author":"Drey","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"2021070806492578700_sfab070-B26","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1093\/ndt\/gfm396","article-title":"Elevated relative mortality risk with mild-to-moderate chronic kidney disease decreases with age","volume":"22","author":"Raymond","year":"2007","journal-title":"Nephrol Dial"},{"key":"2021070806492578700_sfab070-B27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2215\/CJN.03530410","article-title":"Clinical practices and outcomes in elderly hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"6","author":"Canaud","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2007080837","article-title":"Acute kidney injury increases risk of ESRD among elderly","volume":"20","author":"Ishani","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B29","doi-asserted-by":"crossref","first-page":"e002063","DOI":"10.1136\/bmjgh-2019-002063","article-title":"The global and national burden of chronic kidney disease attributable to ambient fine particulate matter air pollution: a modelling study","volume":"5","author":"Bowe","year":"2020","journal-title":"BMJ Glob Health"},{"key":"2021070806492578700_sfab070-B30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/toxins10060237","article-title":"Deleting death and dialysis: conservative care of cardio-vascular risk and kidney function loss in chronic kidney disease (CKD)","volume":"10","author":"Vanholder","year":"2018","journal-title":"Toxins"},{"key":"2021070806492578700_sfab070-B31","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.kint.2016.04.008","article-title":"Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors","volume":"90","author":"Cortazar","year":"2016","journal-title":"Kidney Int"},{"key":"2021070806492578700_sfab070-B32","doi-asserted-by":"crossref","first-page":"e004439","DOI":"10.1161\/CIRCINTERVENTIONS.116.004439","article-title":"Longitudinal risk of adverse events in patients with acute kidney injury after percutaneous coronary intervention: insights from the national cardiovascular data registry","volume":"10","author":"Valle","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"2021070806492578700_sfab070-B33","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2018.12.005","article-title":"Increasing access to integrated ESKD care as part of universal health coverage","volume":"95(4S","author":"Harris","year":"2019","journal-title":"Kidney Int"},{"key":"2021070806492578700_sfab070-B34"},{"key":"2021070806492578700_sfab070-B35","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"key":"2021070806492578700_sfab070-B36","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis","volume":"375","author":"Matsushita","year":"2010","journal-title":"Lancet"},{"key":"2021070806492578700_sfab070-B37","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1681\/ASN.2018101037","article-title":"Burden of CKD and cardiovascular disease on life expectancy and health service utilization: a cohort study of Hong Kong Chinese hypertensive patients","volume":"30","author":"Wan","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B38","first-page":"253","article-title":"Chronic kidney disease and cancer: a troubling connection","volume":"23","author":"Stengel","year":"2010","journal-title":"J Nephrol"},{"key":"2021070806492578700_sfab070-B39","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000330673","article-title":"Chronic kidney disease and risk of death from infection","volume":"34","author":"Wang","year":"2011","journal-title":"Am J Nephrol"},{"key":"2021070806492578700_sfab070-B40"},{"key":"2021070806492578700_sfab070-B41","first-page":"S215","volume-title":"Am J Kidney Dis","year":"2016"},{"key":"2021070806492578700_sfab070-B42","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/ckj\/sfaa048","article-title":"The ERA-EDTA registry annual report 2017: a summary","volume":"13","author":"Kramer","year":"2020","journal-title":"Clin Kidney J"},{"key":"2021070806492578700_sfab070-B43","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.2215\/CJN.00710113","article-title":"World incidence of AKI: a meta-analysis","volume":"8","author":"Susantitaphong","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13613-017-0260-y","article-title":"Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference","volume":"7","author":"Bellomo","year":"2017","journal-title":"Ann Intensive Care"},{"key":"2021070806492578700_sfab070-B45","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1164\/rccm.201604-0799OC","article-title":"Recovery after acute kidney injury","volume":"195","author":"Kellum","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2021070806492578700_sfab070-B46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrneph.2017.63","article-title":"Reducing the costs of chronic kidney disease while delivering quality health care: a call to action","volume":"13","author":"Vanholder","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B47","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-020-0315-4","article-title":"The current and future landscape of dialysis","volume":"16","author":"Himmelfarb","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B48","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1681\/ASN.2011111094","article-title":"Reimbursement of dialysis: a comparison of seven countries","volume":"23","author":"Vanholder","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B49","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2215\/CJN.08150718","article-title":"An international analysis of dialysis services reimbursement","volume":"14","author":"van der Tol","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B50","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/ndt\/gfaa035","article-title":"A call for harmonization of European kidney care: dialysis reimbursement and distribution of kidney replacement therapies","volume":"35","author":"van der Tol","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1524-4733.2009.00668.x","article-title":"Cost-effectiveness of screening and optimal management for diabetes, hypertension, and chronic kidney disease: a modeled analysis","volume":"13","author":"Howard","year":"2010","journal-title":"Value Health"},{"key":"2021070806492578700_sfab070-B52","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1093\/ndt\/gfq780","article-title":"Cost-effectiveness analysis of renal replacement therapy in Austria","volume":"26","author":"Haller","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B53","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/ndt\/gfy390","article-title":"How to increase kidney transplant activity throughout Europe\u2013an advocacy review by the European Kidney Health Alliance","volume":"34","author":"Vanholder","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B54","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/ckj\/sfx149","article-title":"The European Renal Association\u2013European Dialysis and Transplant Association (ERA-EDTA) registry annual report 2015: a summary","volume":"11","author":"Kramer","year":"2018","journal-title":"Clin Kidney J"},{"key":"2021070806492578700_sfab070-B55","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1001\/jama.291.6.697","article-title":"Patient ratings of dialysis care with peritoneal dialysis vs hemodialysis","volume":"291","author":"Rubin","year":"2004","journal-title":"JAMA"},{"key":"2021070806492578700_sfab070-B56","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1440-1797.2012.01651.x","article-title":"Australian consumer perspectives on dialysis: first national census","volume":"17","author":"Ludlow","year":"2012","journal-title":"Nephrology (Carlton)"},{"key":"2021070806492578700_sfab070-B57","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/01.ASN.0000113315.81448.CA","article-title":"Changes in quality of life during hemodialysis and peritoneal dialysis treatment: generic and disease specific measures","volume":"15","author":"Wu","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B58","doi-asserted-by":"crossref","first-page":"iii73","DOI":"10.1093\/ndt\/gfs269","article-title":"Estimating the financial cost of chronic kidney disease to the NHS in England","volume":"27(Suppl 3","author":"Kerr","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B59","doi-asserted-by":"crossref","first-page":"e0231375","DOI":"10.1371\/journal.pone.0231375","article-title":"Costs of patients with chronic kidney disease in Germany","volume":"15","author":"Gandjour","year":"2020","journal-title":"PLoS One"},{"key":"2021070806492578700_sfab070-B60","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1681\/ASN.2012040392","article-title":"Medical costs of CKD in the Medicare population","volume":"24","author":"Honeycutt","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B61","doi-asserted-by":"crossref","first-page":"e0230512","DOI":"10.1371\/journal.pone.0230512","article-title":"The impact of chronic kidney disease on developed countries from a health economics perspective: a systematic scoping review","volume":"15","author":"Elshahat","year":"2020","journal-title":"PLoS One"},{"key":"2021070806492578700_sfab070-B62","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12916-017-0978-2","article-title":"The extra cost of comorbidity: multiple illnesses and the economic burden of non-communicable diseases","volume":"15","author":"Cortaredona","year":"2017","journal-title":"BMC Med"},{"key":"2021070806492578700_sfab070-B63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejca.2020.01.011","article-title":"The cost of cancer in Europe 2018","volume":"129","author":"Hofmarcher","year":"2020","journal-title":"Eur J Cancer"},{"key":"2021070806492578700_sfab070-B64","doi-asserted-by":"crossref","first-page":"108072","DOI":"10.1016\/j.diabres.2020.108072","article-title":"Global and regional estimates and projections of diabetes-related health expenditure: results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"162","author":"Williams","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"2021070806492578700_sfab070-B65","doi-asserted-by":"crossref","first-page":"e0220800","DOI":"10.1371\/journal.pone.0220800","article-title":"Healthcare costs of patients on different renal replacement modalities - analysis of Dutch health insurance claims data","volume":"14","author":"Mohnen","year":"2019","journal-title":"PLoS One"},{"key":"2021070806492578700_sfab070-B66"},{"key":"2021070806492578700_sfab070-B67","doi-asserted-by":"crossref","first-page":"e0158765","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease \u2013 a systematic review and meta-analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PLoS One"},{"key":"2021070806492578700_sfab070-B68","first-page":"459","article-title":"The cost of patients with chronic kidney failure before dialysis: results from the IRIDE observational study","volume":"2","author":"Jommi","year":"2018","journal-title":"Pharm Open"},{"key":"2021070806492578700_sfab070-B69","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/ndt\/gfu016","article-title":"The economic impact of acute kidney injury in England","volume":"29","author":"Kerr","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B70","doi-asserted-by":"crossref","first-page":"70","DOI":"10.12788\/jhm.2683","article-title":"Cost of acute kidney injury in hospitalized patients","volume":"12","author":"Silver","year":"2017","journal-title":"J Hosp Med"},{"key":"2021070806492578700_sfab070-B71","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1001\/jama.2017.4046","article-title":"Assessment of global kidney health care status","volume":"317","author":"Bello","year":"2017","journal-title":"JAMA"},{"key":"2021070806492578700_sfab070-B72","doi-asserted-by":"crossref","first-page":"l5873","DOI":"10.1136\/bmj.l5873","article-title":"Status of care for end stage kidney disease in countries and regions worldwide: international cross sectional survey","volume":"367","author":"Bello","year":"2019","journal-title":"BMJ"},{"key":"2021070806492578700_sfab070-B73","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/sdi.12324","article-title":"Green dialysis: the environmental challenges ahead","volume":"28","author":"Agar","year":"2015","journal-title":"Semin Dial"},{"key":"2021070806492578700_sfab070-B74","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/ndt\/gfy369","article-title":"Lancet countdown paper: what does it mean for nephrology?","volume":"34","author":"Blankestijn","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B75","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.kint.2017.03.047","article-title":"Climate change and kidney disease\u2014threats and opportunities","volume":"92","author":"Barraclough","year":"2017","journal-title":"Kidney Int"},{"key":"2021070806492578700_sfab070-B76","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/ndt\/gfaa339","article-title":"COVID-19 and policy changes for kidney disease: the need for a \u2018decade of the kidney\u2019","volume":"36","author":"Vanholder","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B77","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"2021070806492578700_sfab070-B78","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"2021070806492578700_sfab070-B79","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using open SAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"2021070806492578700_sfab070-B80","doi-asserted-by":"crossref","first-page":"e1003","DOI":"10.1016\/S2214-109X(20)30264-3","article-title":"Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study","volume":"8","author":"Clark","year":"2020","journal-title":"Lancet Glob Health"},{"key":"2021070806492578700_sfab070-B81","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.kint.2020.09.006","article-title":"Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe","volume":"98","author":"Jager","year":"2020","journal-title":"Kidney Int"},{"key":"2021070806492578700_sfab070-B82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/ndt\/gfaa314","article-title":"Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA","volume":"36","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B83","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41581-020-00349-4","article-title":"CKD is a key risk factor for COVID-19 mortality","volume":"16","author":"Gansevoort","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B84"},{"key":"2021070806492578700_sfab070-B85","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1681\/ASN.2020040419","article-title":"Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology","volume":"31","author":"Batlle","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B86","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1681\/ASN.2020030276","article-title":"Renal involvement and early prognosis in patients with COVID-19 pneumonia","volume":"31","author":"Pei","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B87","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area","volume":"323","author":"Richardson","year":"2020","journal-title":"JAMA"},{"key":"2021070806492578700_sfab070-B88","doi-asserted-by":"crossref","first-page":"880","DOI":"10.2215\/CJN.05180420","article-title":"Impending shortages of kidney replacement therapy for COVID-19 patients","volume":"15","author":"Goldfarb","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B89","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(20)31692-5","article-title":"Donation and transplantation activity in the UK during the COVID-19 lockdown","volume":"396","author":"Manara","year":"2020","journal-title":"Lancet"},{"key":"2021070806492578700_sfab070-B90","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41581-020-00340-z","article-title":"The impact of COVID-19 on kidney transplantation","volume":"16","author":"Alasfar","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B91","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1681\/ASN.2020050729","article-title":"Increasing peritoneal dialysis use in response to the COVID-19 pandemic: will it go viral?","volume":"31","author":"Brown","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B92","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2215\/CJN.03540320","article-title":"On the frontline of the COVID-19 outbreak: keeping patients on long-term dialysis safe","volume":"15","author":"Watnick","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B93","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s40620-020-00794-1","article-title":"Exposure to novel coronavirus in patients on renal replacement therapy during the exponential phase of COVID-19 pandemic: survey of the Italian Society of Nephrology","volume":"33","author":"Quintaliani","year":"2020","journal-title":"J Nephrol"},{"key":"2021070806492578700_sfab070-B94","doi-asserted-by":"crossref","DOI":"10.2215\/CJN.08400520","article-title":"Mass disasters and burnout in nephrology personnel: from earthquakes and hurricanes to COVID-19 pandemic","author":"Sever","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021070806492578700_sfab070-B95","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/ndt\/gfab007","article-title":"At least 156 reasons to prioritise COVID-19 vaccination in patients receiving in-centre haemodialysis","volume":"36","author":"Combe","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B96"},{"key":"2021070806492578700_sfab070-B97","doi-asserted-by":"crossref","DOI":"10.4269\/ajtmh.20-1506","article-title":"Who will pay for the COVID-19 vaccines for Africa?","author":"Lucero-Prisno","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"2021070806492578700_sfab070-B98","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/aor.13621","article-title":"The Kidney Health Initiative innovation roadmap for renal replacement therapies: building the yellow brick road, while updating the map","volume":"44","author":"Wieringa","year":"2020","journal-title":"Artif Organs"},{"key":"2021070806492578700_sfab070-B99","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1007\/s00125-018-4670-7","article-title":"SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review","volume":"61","author":"Verma","year":"2018","journal-title":"Diabetologia"},{"key":"2021070806492578700_sfab070-B100","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1007\/s00125-018-4678-z","article-title":"SGLT2 inhibitors: the future for treatment of type 2 diabetes mellitus and other chronic diseases","volume":"61","author":"Wanner","year":"2018","journal-title":"Diabetologia"},{"key":"2021070806492578700_sfab070-B101"},{"key":"2021070806492578700_sfab070-B102","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-8587(16)30291-1","article-title":"The Lancet Diabetes Endocrinology. Diabetes and NCD research: meeting the needs of the patient","volume":"4","year":"2016","journal-title":"Lancet Diabet Endocrinol"},{"key":"2021070806492578700_sfab070-B103","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S2213-8587(16)30420-X","article-title":"Non-communicable disease funding","volume":"5","author":"Allen","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2021070806492578700_sfab070-B104","doi-asserted-by":"crossref","first-page":"e006648","DOI":"10.1136\/bmjopen-2014-006648","article-title":"UK research spend in 2008 and 2012: comparing stroke, cancer, coronary heart disease and dementia","volume":"5","author":"Luengo-Fernandez","year":"2015","journal-title":"BMJ Open"},{"key":"2021070806492578700_sfab070-B105"},{"key":"2021070806492578700_sfab070-B106","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/annonc\/mdx053","article-title":"Clinical benefit, price and approval characteristics of FDA-approved new drugs for treating advanced solid cancer, 2000\u20132015","volume":"28","author":"Vivot","year":"2017","journal-title":"Ann Oncol"},{"key":"2021070806492578700_sfab070-B107"},{"key":"2021070806492578700_sfab070-B108","doi-asserted-by":"crossref","first-page":"l4726","DOI":"10.1136\/bmj.l4726","article-title":"Defining the concept of fair pricing for medicines","volume":"368","author":"Moon","year":"2020","journal-title":"BMJ"},{"key":"2021070806492578700_sfab070-B109","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfaa163","article-title":"Funding kidney research as a public health priority: challenges and opportunities","author":"Zoccali","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2021070806492578700_sfab070-B110"},{"key":"2021070806492578700_sfab070-B111"},{"key":"2021070806492578700_sfab070-B112"},{"key":"2021070806492578700_sfab070-B113","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2471\/BLT.17.206441","article-title":"The global burden of kidney disease and the sustainable development goals","volume":"96","author":"Luyckx","year":"2018","journal-title":"Bull World Health Org"},{"key":"2021070806492578700_sfab070-B114"},{"key":"2021070806492578700_sfab070-B115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41581-020-00363-6","article-title":"Sustainable development goals relevant to kidney health: an update on progress","volume":"17","author":"Luyckx","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"2021070806492578700_sfab070-B116"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfab070\/38612065\/sfab070.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/7\/1719\/38822138\/sfab070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/7\/1719\/38822138\/sfab070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T04:10:26Z","timestamp":1671855026000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/14\/7\/1719\/6243030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,20]]},"references-count":116,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4,20]]},"published-print":{"date-parts":[[2021,6,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfab070","relation":{},"ISSN":["2048-8513"],"issn-type":[{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,4,20]]}}}