{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:51:44Z","timestamp":1768038704364,"version":"3.49.0"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We report on the onset of minimal change disease (MCD) presenting with anasarca after a second dose of the messenger RNA (mRNA)-based Pfizer-BioNTech vaccine against coronavirus disease 2019 (COVID-19). A 75-year-old previously healthy male was admitted with rapidly progressive anasarca and proteinuria of 7.7 g\/day following the second dose. A kidney biopsy revealed MCD with nephrotic syndrome. He was treated with intravenous methylprednisolone followed by prednisolone, leading to complete remission after 35 days in the hospital. Since definite causality between the vaccine and MCD remains unclear, awareness of this potential adverse effect of mRNA vaccines is important to determine its true incidence and frequency.<\/jats:p>","DOI":"10.1093\/ckj\/sfab156","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T14:03:28Z","timestamp":1629986608000},"page":"2606-2607","source":"Crossref","is-referenced-by-count":16,"title":["Minimal change disease soon after Pfizer-BioNTech COVID-19 vaccination"],"prefix":"10.1093","volume":"14","author":[{"given":"Seiji","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University Chiba Medical Center, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Fugo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Teikyo University Chiba Medical Center, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Teikyo University Chiba Medical Center, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Terawaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University Chiba Medical Center, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"2021122112473839800_sfab156-B1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1053\/j.ajkd.2021.03.010","article-title":"Minimal change disease following the Pfizer-BioNTech COVID-19 vaccine","volume":"78","author":"Lebedev","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"2021122112473839800_sfab156-B2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.kint.2021.04.035","article-title":"Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine","volume":"100","author":"D'Agati","year":"2021","journal-title":"Kidney Int"},{"key":"2021122112473839800_sfab156-B3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2215\/CJN.05000516","article-title":"Minimal change disease","volume":"12","author":"Vivarelli","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021122112473839800_sfab156-B4","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1038\/ncomms4566","article-title":"Nucleic acid sensing by T cells initiates Th2 cell differentiation","volume":"5","author":"Imanishi","year":"2014","journal-title":"Nat Commun"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfab156\/40521431\/sfab156.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/14\/12\/2606\/41838019\/sfab156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/14\/12\/2606\/41838019\/sfab156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T12:49:05Z","timestamp":1640090945000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/14\/12\/2606\/6358132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":4,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,8,26]]},"published-print":{"date-parts":[[2021,12,21]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfab156","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12]]},"published":{"date-parts":[[2021,8,26]]}}}