{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:38:51Z","timestamp":1782423531067,"version":"3.54.5"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030022"],"award-info":[{"award-number":["82030022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770683"],"award-info":[{"award-number":["81770683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970586"],"award-info":[{"award-number":["81970586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900626"],"award-info":[{"award-number":["81900626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major International (Regional) Joint Research Project","award":["81620108003"],"award-info":[{"award-number":["81620108003"]}]},{"name":"Guangzhou Regenerative Medicine and Health\u2013Guangdong Laboratory Research Grant","award":["2018GZR0201003"],"award-info":[{"award-number":["2018GZR0201003"]}]},{"name":"Major Scientific and Technological Planning Project of Guangzhou","award":["201607020004"],"award-info":[{"award-number":["201607020004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have suggested that long-term exposure to air pollution increases the risk of chronic kidney disease and its progression. However, the effect of air pollution on the risk of acute kidney injury (AKI) has not been studied. We aim to evaluate the transient effect of air pollution on the risk of hospital-acquired AKI (HA-AKI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected from the Epidemiology of AKI in Chinese Hospitalized patients cohort AKI cases in which the onset date could be unambiguously determined. We obtained city-specific daily averages of the ambient level of particulate matter (2.5 \u03bcm and 10 \u03bcm), carbon monoxide, nitrogen dioxide (NO2), sulfur dioxide (SO2) and ozone (O3) from the Ministry of Environmental Protection of China. We used the time-stratified case-crossover approach to examine the association between the ambient level of air pollutants and the risk of HA-AKI in the selected cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 293 AKI cases that met the inclusion and exclusion criteria were selected. In univariable analysis, the ambient levels of NO2 and SO2 were significantly associated with the risk of HA-AKI. In the multivariable analysis that incorporated all six pollutants in the same model, NO2 was the sole pollutant whose level remained associated with the risk of AKI (P &amp;lt; 0.001). The relationship between the level of NO2 and the risk of HA-AKI appeared to be linear, with an estimated odds ratio of 1.063 (95% confidence interval 1.026\u20131.101) for each increment of 1 median absolute deviation in the exposure. The association was consistent across the subgroups stratified by age, gender, baseline estimated glomerular filtration rate, AKI severity, need for intensive care and season.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher ambient levels of NO2 are associated with an increased risk of HA-AKI in hospitalized adults in China.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ckj\/sfab164","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T14:48:04Z","timestamp":1631026084000},"page":"95-100","source":"Crossref","is-referenced-by-count":16,"title":["Higher ambient nitrogen dioxide is associated with an elevated risk of hospital-acquired acute kidney injury"],"prefix":"10.1093","volume":"15","author":[{"given":"Pinghong","family":"He","sequence":"first","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"},{"name":"Renal Division, Department of Medicine, Guizhou Provincial People\u2019s Hospital, Guizhou Provincial Institute of Nephritic and Urinary Disease, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Li","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licong","family":"Su","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Dong","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zha","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Guizhou Provincial People\u2019s Hospital, Guizhou Provincial Institute of Nephritic and Urinary Disease, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Nie","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan Fan","family":"Hou","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"2022031114553954000_sfab164-B1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrneph.2018.11","article-title":"Environmental pollution and kidney diseases","volume":"14","author":"Xu","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"2022031114553954000_sfab164-B2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 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