{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:54:20Z","timestamp":1776063260068,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Canaria de Investigaci\u00f3n Sanitaria","award":["PIFUN18-17"],"award-info":[{"award-number":["PIFUN18-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In living kidney transplantation there are two different individuals, a healthy donor and a renal transplant recipient. This is an excellent human model to study factors that influence kidney function in the context of reduced renal mass and the adaptation of two comparable kidneys to different metabolic demands.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed the changes in measured glomerular filtration rate (GFR, iohexol) from pretransplantation to 12 months after transplantation in 30 donor\u2013recipient pairs. Each donor was compared with his\/her recipient. We defined a priori three different groups based on GFR differences at 12 months: donor\u00a0&amp;gt;\u00a0recipient (Group A; 78 \u00b1 8 versus 57 \u00b1 8 mL\/min), donor\u00a0&amp;lt;\u00a0recipient (Group B; 65 \u00b1 11 versus 79 \u00b1 11 mL\/min) and donor\u00a0\u2248\u00a0recipient (Group C; 66 \u00b1 7 versus 67 \u00b1 7 mL\/min). Other factors like donor\/recipient mismatches in body mass index (BMI), surface area and gender were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In Group A donors were mostly male and recipients were female (75% each). Donors had a higher baseline weight than their recipients. During follow-up, weight remained stable in donors but increased 7% in recipients. In Group B donors were mostly female (60%) and recipients male. At baseline, donors had a lower weight than recipients. At 12 months, weight was stable in donors but increased in recipients. In Group C donors were mostly (75%) female and recipients male. At baseline, donors had a higher BMI than their recipients. At 12 months, BMI was stable in donors but increased 14% in recipients. In multivariable analysis, higher GFR at 12 months was associated with higher baseline weight and GFR in donors and with male gender and higher baseline weight in recipients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Kidneys from living donors are more \u2018plastic\u2019 than originally thought and respond to metabolic demands and weight changes of their new host. These changes should be taken into account when assessing GFR outcomes in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfab220","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T04:43:19Z","timestamp":1643431399000},"page":"885-894","source":"Crossref","is-referenced-by-count":8,"title":["Early glomerular filtration rate changes in living kidney donors and recipients: an example of renal plasticity"],"prefix":"10.1093","volume":"15","author":[{"given":"Ana Gonz\u00e1lez","family":"Rinne","sequence":"first","affiliation":[{"name":"Department of Nephrology, University Hospital of the Canary Islands, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian Acosta","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of the Canary Islands, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3540-8252","authenticated-orcid":false,"given":"Sergio Luis","family":"Lima","sequence":"additional","affiliation":[{"name":"IIS-Fundaci\u00f3n Jim\u00e9nez Diaz, Department of Medicine, School of Medicine, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta G\u00f3mez","family":"Gil","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Universitario de Canarias, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia Negr\u00edn","family":"Mena","sequence":"additional","affiliation":[{"name":"Research Unit Department, Unidad de Investigaci\u00f3n Cl\u00ednica y Ensayos Cl\u00ednicos, Hospital Universitario de Canarias, Tenerife, Spain"},{"name":"LFR Laboratorio de Funci\u00f3n Renal, Universidad de La Laguna, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D\u00edaz","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Research Unit Department, Unidad de Investigaci\u00f3n Cl\u00ednica y Ensayos Cl\u00ednicos, Hospital Universitario de Canarias, Tenerife, Spain"},{"name":"LFR Laboratorio de Funci\u00f3n Renal, Universidad de La Laguna, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelaida","family":"Morales","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General de Lanzarote, Arrecife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicanor","family":"Vega","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Doctor Negr\u00edn, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Gallego","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edduin Mart\u00edn","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General de La Palma, Santa Cruz de La Palma, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Cabello","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General de La Palma, Santa Cruz de La Palma, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-864X","authenticated-orcid":false,"given":"Ana Elena Rodr\u00edguez","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n General de la Universidad de La Laguna, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Pimentel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of La Laguna, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Escamilla","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of the Canary Islands, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coriolano","family":"Cruz","sequence":"additional","affiliation":[{"name":"Research Unit Department, Unidad de Investigaci\u00f3n Cl\u00ednica y Ensayos Cl\u00ednicos, Hospital Universitario de Canarias, Tenerife, Spain"},{"name":"LFR Laboratorio de Funci\u00f3n Renal, Universidad de La Laguna, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes P\u00e9rez","family":"Tamaj\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of the Canary Islands, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando Torres","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of the Canary Islands, Tenerife, Spain"},{"name":"Internal Medicine Department, Universidad de La Laguna, ITB Instituto de Tecnolog\u00edas Biom\u00e9dicas, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Gaspari","sequence":"additional","affiliation":[{"name":"LFR Laboratorio de Funci\u00f3n Renal, Universidad de La Laguna, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"IIS-Fundaci\u00f3n Jim\u00e9nez Diaz, Department of Medicine, School of Medicine, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Renal, Instituto Carlos III-FEDER, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Porrini","sequence":"additional","affiliation":[{"name":"Research Unit Department, Unidad de Investigaci\u00f3n Cl\u00ednica y Ensayos Cl\u00ednicos, Hospital Universitario de Canarias, Tenerife, Spain"},{"name":"LFR Laboratorio de Funci\u00f3n Renal, Universidad de La Laguna, Tenerife, Spain"},{"name":"Faculty of Medicine, University of La Laguna, Tenerife, Spain"},{"name":"Internal Medicine Department, Universidad de La Laguna, ITB Instituto de Tecnolog\u00edas 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