{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:16:22Z","timestamp":1768072582645,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after mRNA or adenoviral vector-based vaccines is weak in kidney transplant (KT) patients. However, few studies have focused on humoral response after inactivated virus-based vaccines in KT. Here, we compare antibody response following vaccination with inactivated virus (CoronaVac\u00ae) and BNT162b2 mRNA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A national multicentre cross-sectional study was conducted. The study group was composed of patients from all KT centres in Uruguay, vaccinated between 1 and 31 May 2021 (CoronaVac\u00ae, n = 245 and BNT162b2, n = 39). The control group was constituted of 82 healthy individuals. Participants had no prior confirmed coronavirus disease 2019 (COVID-19) test. Blood samples were collected between 30 and 40 days after the second dose. Serum-specific immunoglobulin G (IgG) antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 Spike protein were determined using the COVID-19 IgG QUANT ELISA Kit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Only 29% of KT recipients showed seroconversion (36.5% BNT162b2, 27.8% inactivated virus, P = 0.248) in comparison with 100% in healthy control with either vaccine. Antibody levels against RBD were higher with BNT162b mRNA than with inactivated virus [median (interquartile range) 173 (73\u2013554) and 29 (11\u201370) binding antibody units (BAU)\/mL, P &amp;lt; 0.034] in KT and 10 times lower than healthy control [inactivated virus: 308 (209\u2013335) and BNT162b2: 2638 (2608\u20133808) BAU\/mL, P &amp;lt; 0.034]. In multivariate analysis, variables associated with negative humoral response were age, triple immunosuppression, estimated glomerular filtration rate and time post-KT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Seroconversion was low in KT patients after vaccination with both platforms. Antibody levels against SARS-CoV-2 were lower with inactivated virus than BNT162b mRNA. These findings support the need for strategies to improve immunogenicity in KT recipients after two doses of either vaccine.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfab291","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T12:56:41Z","timestamp":1640177801000},"page":"527-533","source":"Crossref","is-referenced-by-count":28,"title":["Comparison of antibody response to SARS-CoV-2 after two doses of inactivated virus and BNT162b2 mRNA vaccines in kidney transplant"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-104X","authenticated-orcid":false,"given":"Mariana","family":"Seija","sequence":"first","affiliation":[{"name":"Centro de Nefrolog\u00eda, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Departamento de Fisiopatolog\u00eda, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Rammauro","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunovirolog\u00eda, Institut Pasteur de Montevideo, Montevideo, Uruguay"},{"name":"Departamento de Inmunobiolog\u00eda, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Santiago","sequence":"additional","affiliation":[{"name":"Centro de Nefrolog\u00eda, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Orihuela","sequence":"additional","affiliation":[{"name":"Centro de Trasplante INU, Hospital Italiano, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Zulberti","sequence":"additional","affiliation":[{"name":"Centro de Trasplante INU, Hospital Italiano, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Machado","sequence":"additional","affiliation":[{"name":"Centro de Trasplante, Hospital Evang\u00e9lico, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Recalde","sequence":"additional","affiliation":[{"name":"Centro de Trasplante, Hospital Evang\u00e9lico, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Noboa","sequence":"additional","affiliation":[{"name":"Centro de Nefrolog\u00eda, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Departamento de Inmunobiolog\u00eda, Facultad de Medicina, Universidad de la 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