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In the serum, type 1 cryoglobulins were present and a kidney biopsy showed ischaemic glomeruli, with thrombosis of the larger interlobular arteries. Other causes of thrombotic microangiopathy were excluded. Bone marrow immunophenotyping showed 1% monoclonal plasma cells. A diagnosis of monoclonal gammopathy of renal significance was made. Haematological treatment resulted in haematological and renal response.<\/jats:p>","DOI":"10.1093\/ckj\/sfac078","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T04:12:45Z","timestamp":1646971965000},"page":"1425-1428","source":"Crossref","is-referenced-by-count":5,"title":["Monoclonal gammopathy of renal significance presenting with cryoglobulinaemia type I associated severe thrombotic microangiopathy"],"prefix":"10.1093","volume":"15","author":[{"given":"Eva","family":"Hesius","sequence":"first","affiliation":[{"name":"Radboudumc, Department of Haematology , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-3651","authenticated-orcid":false,"given":"Kim","family":"Bunthof","sequence":"additional","affiliation":[{"name":"Radboudumc, Department of Nephrology , Nijmegen , The Netherlands"},{"name":"Bravis Hospital, Department of Internal Medicine , Roosendaal , The 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