{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:02:08Z","timestamp":1782532928456,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We report a case of a patient who had critically low serum bicarbonate (HCO3\u2212) levels ranging from 8 to 11\u00a0mmol\/L on repeated venous measurements using an enzymatic\/photometric assay. This prompted hospitalization and treatment with intravenous sodium bicarbonate (NaHCO3) followed by oral NaHCO3. He was evaluated for potential causes of high anion gap metabolic acidosis without any etiology found. He continued to have low serum HCO3\u2212 levels despite maintenance oral NaHCO3 therapy and was referred for a second opinion where further laboratory work was pursued. An arterial blood gas was obtained, which revealed normal whole blood pH and HCO3\u2212 levels. A different enzymatic\/photometric assay revealed a normal serum HCO3\u2212 level at 21\u00a0mmol\/L. Additional workup revealed paraproteinemia, which was thought to interfere with the enzymatic process by which his serum HCO3\u2212 was measured, resulting in erroneous values.<\/jats:p>","DOI":"10.1093\/ckj\/sfac088","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T10:17:26Z","timestamp":1661249846000},"page":"2154-2156","source":"Crossref","is-referenced-by-count":4,"title":["Pseudohypobicarbonatemia in a patient with amyloidosis"],"prefix":"10.1093","volume":"15","author":[{"given":"Marvi","family":"Bukhari","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh Medical Center, Mercy Hospital , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary","family":"Boyd-Shiwarski","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, PA, 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